Proteomic adaptation to chronic high intensity swimming training in the rat heart

Author(s):  
Biao Sun ◽  
Jun hong Wang ◽  
Yuan yuan Lv ◽  
Shu shu Zhu ◽  
Jin Yang ◽  
...  
2003 ◽  
Vol 285 (6) ◽  
pp. H2639-H2647 ◽  
Author(s):  
M. O. Boluyt ◽  
A. M. Loyd ◽  
M. H. Roth ◽  
M. J. Randall ◽  
E. Y. M. Song

The purpose of the study was to determine whether exercise would activate JNK in the heart and whether chronic exercise training would alter the response. Untrained rats were familiarized with the treadmill and assigned to one of four groups: low intensity (LI), 10 min, 0%, 15 m/min; medium intensity (MI), 10 min, 0%, 33 m/min; high intensity (HI), 10 min, 25%, 33 m/min; long duration (LD), 30 min, 0%, 15 m/min. Another cohort of rats was subjected to a progressive 6 wk high-intensity training protocol that produced a 12% increase in heart mass. In untrained rats, JNK activity was LI: 1.5 (fold nonrun control), MI: 2.0, HI: 2.5, LD: 1.25 immediately after a single bout of exercise. In trained rats, no activation of JNK above baseline was detected after either a 10-min or 1-h bout of exercise. We concluded that treadmill exercise activates JNK in the rat heart in an intensity-dependent manner and that chronic training abrogates the myocardial JNK response to a bout of exercise.


2016 ◽  
Vol 48 ◽  
pp. 1028
Author(s):  
José Pedro Morgado ◽  
Cristina Paula Monteiro ◽  
Maria Teresa Seixas ◽  
Marta Alvim ◽  
Mafalda Bourbon ◽  
...  

2018 ◽  
Vol 1 (5) ◽  
Author(s):  
Nianyun Zhang

Objective To study the effects of different exercise patterns on TWEAK and its downstream NF-kB/ MuRF1 in rat skeletal muscle, and to explore the relationship between TWEAK and skeletal muscle metabolism by different exercise interventions. Methods Thirty-two male Sprague-Dawley rats aged 12 weeks were randomly divided into 4 groups: quiet group, high-intensity intermittent swimming group, medium-intensity continuous swimming group, and ladder-moving group, with 8 rats in each group. The exercise group adopted high-intensity intermittent swimming training, medium-intensity continuous swimming training, and ladder training, and trained for 5 days per week for 8 weeks. The right gastrocnemius muscle of the rat was taken the next day after the last training. The expression of TWEAK, NF-KB, MuRF1 proteins was detected by Western Blot. Results 1. The gastrocnemius muscle mass index exercise group was higher than the quiet group. 2. Compared with the quiet group, the expression of TWEAK in the exercise group was reduced, and the reduction in the ladder exercise group was more significant. 3. Compared with the quiet group, the expression of NF-KB and MURF1 was decreased in the exercise group, and the reduction in the ladder exercise group was more significant. Conclusions  TWEAK may be involved in skeletal muscle catabolism. All three exercise patterns can alleviate skeletal muscle atrophy in rats, and the effect of ladder movement is more significant.


2010 ◽  
Vol 36 (1) ◽  
pp. 158-165 ◽  
Author(s):  
Sophie Hernot ◽  
Bernard Cosyns ◽  
Steven Droogmans ◽  
Christian Garbar ◽  
Pedro Couck ◽  
...  

2012 ◽  
Vol 113 (07) ◽  
pp. 393-399 ◽  
Author(s):  
N. Okudan ◽  
S. Revan ◽  
S. S. Balci ◽  
M. Belviranli ◽  
H. Pepe ◽  
...  

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