Caffeic acid phenethyl ester as a protective agent against doxorubicin nephrotoxicity in rats

Application of cisplatin (CP) for the treatment of different cancers is known to cause pancreatitis through an increase in reactive oxygen species production and promotion of inflammation. Caffeic acid phenethyl ester (CAPE), the main activity carrier of propolis extracts, was previously found to possess numerous beneficial properties. This study aims to determine for the first time the potential of CAPE in preventing CP-induced pancreatic tissue damage by studying the changes occurring on both biochemical and microscopic levels. The levels of serum α-amylase and a panel of pancreatic tissue biomarkers related to tissue injury (reduced glutathione, xanthine oxidase, malondialdehyde, and protein carbonylated concentration) and inflammation (myeloperoxidase, nitric oxide, and umor necrosis factor alpha) were studied in male Wistar rats treated with either CP alone or with CP and CAPE. Additionally, microscopic analysis of pancreatic tissue would be conducted as well. Application of CAPE together with CP statistically significantly prevented the disturbance in all here-studied pancreatic tissue damage and inflammation-related biomarkers. The changes in pancreas biochemical status was followed by morphological disturbance. The results of the present study suggest that CAPE could act as a protective agent in pancreatic damage that arises after CP application.

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Caffeic Acid Phenethyl Ester as a Protective Agent against Nephrotoxicity and/or Oxidative Kidney Damage: A Detailed Systematic Review

The Scientific World JOURNAL ◽

10.1155/2014/561971 ◽

2014 ◽

Vol 2014 ◽

pp. 1-16 ◽

Cited By ~ 14

Author(s):

Sumeyya Akyol ◽

Veli Ugurcu ◽

Aynur Altuntas ◽

Rukiye Hasgul ◽

Ozlem Cakmak ◽

...

Keyword(s):

Systematic Review ◽

Protective Effect ◽

Caffeic Acid ◽

Renal Injury ◽

Active Component ◽

Current Knowledge ◽

Ischemia Reperfusion ◽

Oxidative Injury ◽

Caffeic Acid Phenethyl Ester ◽

Protective Agent

Caffeic acid phenethyl ester (CAPE), an active component of propolis, has been attracting the attention of different medical and pharmaceutical disciplines in recent years because of its antioxidant, anti-inflammatory, antiproliferative, cytotoxic, antiviral, antifungal, and antineoplastic properties. One of the most studied organs for the effects of CAPE is the kidney, particularly in the capacity of this ester to decrease the nephrotoxicity induced by several drugs and the oxidative injury after ischemia/reperfusion (I/R). In this review, we summarized and critically evaluated the current knowledge regarding the protective effect of CAPE in nephrotoxicity induced by several special medicines such as cisplatin, doxorubicin, cyclosporine, gentamycin, methotrexate, and other causes leading to oxidative renal injury, namely, I/R models and senility.

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Caffeic acid phenethyl ester (CAPE) exhibits significant potential as an antidiabetic and liver-protective agent in streptozotocin-induced diabetic rats

Pharmacological Research ◽

10.1016/j.phrs.2009.03.017 ◽

2009 ◽

Vol 60 (4) ◽

pp. 270-276 ◽

Cited By ~ 37

Author(s):

Sefa Celik ◽

Suat Erdogan ◽

Mehmet Tuzcu

Keyword(s):

Caffeic Acid ◽

Caffeic Acid Phenethyl Ester ◽

Diabetic Rats ◽

Protective Agent ◽

Significant Potential

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Cytotoxic activities of 4 natural products – carnosic acid, xanthohumol, caffeic acid phenethyl ester and (-) eburnamonine

Planta Medica ◽

10.1055/s-2007-987383 ◽

2007 ◽

Vol 73 (09) ◽

Author(s):

DT Nga ◽

QH Juan ◽

KE Kyung ◽

T Batmunkh ◽

SJ Yeon ◽

...

Keyword(s):

Natural Products ◽

Caffeic Acid ◽

Caffeic Acid Phenethyl Ester ◽

Carnosic Acid ◽

Cytotoxic Activities

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Novel Caffeic Acid Phenethyl Ester (Cape) Analogues as Inducers of Heme Oxygenase-1

Current Pharmaceutical Design ◽

10.2174/1381612823666170210151411 ◽

2017 ◽

Vol 23 (18) ◽

Cited By ~ 28

Author(s):

Valeria Pittala ◽

Luca Vanella ◽

Loredana Salerno ◽

Claudia Di Giacomo ◽

Rosaria Acquaviva ◽

...

Keyword(s):

Caffeic Acid ◽

Heme Oxygenase ◽

Caffeic Acid Phenethyl Ester ◽

Heme Oxygenase 1

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Determination of antioxidant activity and phenolic compounds for basic standardization of Turkish propolis

Applied Biological Chemistry ◽

10.1186/s13765-021-00608-3 ◽

2021 ◽

Vol 64 (1) ◽

Author(s):

Aslı Özkök ◽

Merve Keskin ◽

Aslı Elif Tanuğur Samancı ◽

Elif Yorulmaz Önder ◽

Çiğdem Takma

Keyword(s):

Antioxidant Capacity ◽

Caffeic Acid ◽

Caffeic Acid Phenethyl Ester ◽

Total Phenolic ◽

Scaling Analysis ◽

Flavonoid Content ◽

Multidimensional Scaling Analysis ◽

Flavonoid Quercetin ◽

Phenolic And Flavonoid

AbstractThis study aimed to determine the standard amount of antioxidant content and compounds of the propolis for the standardization of propolis. For this purpose, the total flavonoids, total phenolic, CUPRAC antioxidant capacity content and the diversity of phenolic and flavonoid components of these propolis samples were found by HPLC determined at the 23 propolis samples which were collected different regions of Turkey. Beside that, the similarities and differences of these 23 provinces to each other according to their antioxidant capacities were investigated by multidimensional scaling analysis. The total flavonoid content in the propolis samples were determined between 21.28 and 152.56 mg CE/g. The total phenolic content in the propolis samples was found between 34.53 mg and 259.4 mg GAE/g. CUPRAC antioxidant capacity of the propolis samples and antioxidant range was found from 95.35 to 710.43 mg TE/g. Also, 4 flavonoid [Quercetin (min.1.12–max.4.14 mg/g), Galangin (min.0.72–max.40.79 mg/g), Apigenin (min.1.07–max.17.35 mg/g), Pinocembrin (min.1.32–max.39.92 mg/g] and 6 phenolic acid [Caffeic acid (min.1.20–max.7.6 mg/g), p-Coumaric acid (min.1.26–max.4.47 mg/g), trans-Ferulic acid (min.1.28–max.4.92 mg/g), Protocatechuic acid (1.78 mg/g), trans-Cinnamic acid (min.1.05–max.3.83 mg/g), Caffeic Acid Phenethyl Ester (CAPE) (min.1.41–max.30.15 mg/g)] components were detected as mg/g, in different ratios in propolis samples collected from different regions. The feature of this study, so far, is to have the maximum number of samples representing the Turkish propolis, and so is thought to help to national and international propolis standard workings.

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