Caffeic acid phenethyl ester attenuates changes in pancreatic tissue damage biomarkers induced by cisplatin

2020 ◽  
Vol 98 (5) ◽  
pp. 296-303 ◽  
Author(s):  
Biljana Stošić ◽  
Radmilo Janković ◽  
Marija Stošić ◽  
Danica Marković ◽  
Ines Veselinović ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Tissue Damage ◽  
Tissue Injury ◽  
Microscopic Analysis ◽  
Caffeic Acid Phenethyl Ester ◽  
Pancreatic Tissue ◽  
Protective Agent ◽  
Necrosis Factor Alpha ◽  
Male Wistar Rats ◽  
Main Activity

Application of cisplatin (CP) for the treatment of different cancers is known to cause pancreatitis through an increase in reactive oxygen species production and promotion of inflammation. Caffeic acid phenethyl ester (CAPE), the main activity carrier of propolis extracts, was previously found to possess numerous beneficial properties. This study aims to determine for the first time the potential of CAPE in preventing CP-induced pancreatic tissue damage by studying the changes occurring on both biochemical and microscopic levels. The levels of serum α-amylase and a panel of pancreatic tissue biomarkers related to tissue injury (reduced glutathione, xanthine oxidase, malondialdehyde, and protein carbonylated concentration) and inflammation (myeloperoxidase, nitric oxide, and umor necrosis factor alpha) were studied in male Wistar rats treated with either CP alone or with CP and CAPE. Additionally, microscopic analysis of pancreatic tissue would be conducted as well. Application of CAPE together with CP statistically significantly prevented the disturbance in all here-studied pancreatic tissue damage and inflammation-related biomarkers. The changes in pancreas biochemical status was followed by morphological disturbance. The results of the present study suggest that CAPE could act as a protective agent in pancreatic damage that arises after CP application.

scholarly journals Caffeic Acid Phenethyl Ester as a Protective Agent against Nephrotoxicity and/or Oxidative Kidney Damage: A Detailed Systematic Review

2014 ◽  
Vol 2014 ◽  
pp. 1-16 ◽  
Author(s):  
Sumeyya Akyol ◽  
Veli Ugurcu ◽  
Aynur Altuntas ◽  
Rukiye Hasgul ◽  
Ozlem Cakmak ◽  
...  
Keyword(s):  
Systematic Review ◽  
Protective Effect ◽  
Caffeic Acid ◽  
Renal Injury ◽  
Active Component ◽  
Current Knowledge ◽  
Ischemia Reperfusion ◽  
Oxidative Injury ◽  
Caffeic Acid Phenethyl Ester ◽  
Protective Agent

Caffeic acid phenethyl ester (CAPE), an active component of propolis, has been attracting the attention of different medical and pharmaceutical disciplines in recent years because of its antioxidant, anti-inflammatory, antiproliferative, cytotoxic, antiviral, antifungal, and antineoplastic properties. One of the most studied organs for the effects of CAPE is the kidney, particularly in the capacity of this ester to decrease the nephrotoxicity induced by several drugs and the oxidative injury after ischemia/reperfusion (I/R). In this review, we summarized and critically evaluated the current knowledge regarding the protective effect of CAPE in nephrotoxicity induced by several special medicines such as cisplatin, doxorubicin, cyclosporine, gentamycin, methotrexate, and other causes leading to oxidative renal injury, namely, I/R models and senility.

scholarly journals Pengaruh Ekstrak Daun Sirsak Terhadap Gambaran Histopatologi Pankreas Rattus Norvegicus Jantan yang Diinduksi Aloksan

2020 ◽  
Vol 17 (2) ◽  
pp. 116
Author(s):  
RIFKY YOGA PRATAMA ◽  
NITA PRANITASARI ◽  
DIAH PURWANINGSARI
Keyword(s):  
Beta Cells ◽  
Tissue Damage ◽  
Rattus Norvegicus ◽  
Pancreatic Beta Cells ◽  
Leaf Extract ◽  
Pancreatic Tissue ◽  
Annona Muricata ◽  
Significant Difference ◽  
Male Wistar Rats ◽  
Diabetes Melitus

<p><strong>ABSTRACT</strong></p><p>               Diabetes melitus is a metabolic disorder characterized by an increase in blood glucose levels caused by disruption of the pancreas in producing insulin. Alloxan is a substrate that can trigger the condition of hyperglycemia which can cause diabetes because of its toxic nature to pancreatic beta cells. Damage to pancreatic beta cells is caused by Reactive Oxygen Species (ROS) which causes necrosis in the pancreatic beta cells. Soursop leaf extract (Annona muricata L.) has antioxidants such as flavonoids and tannins which can inhibit ROS increase.</p><p>               The aim of this study to find out about the effect of soursop leaf (Annona muricata Linn) extract in repaired to pancreatic tissue damage of male wistar rats (Rattus norvegicus) induced by alloxan. This study used 24 male Wistar rats, divided into 3 groups : K(-) group that no treatment, K(+) group that induced by alloxan dose 150mg/kgBW and K(p) group that induced by alloxan dose 150mg/kgBW and given soursop leaf extract dose 150mg/kgBW. The result of this study showed that there was significant difference (p = 0.001) of pancreatic tissue damage measured by histopathologic score between group of no treatment rats compared to the group of rats induced by alloxan. There was a significant difference of pancreatic tissue damage measured by histopatology score group of rats induced by alloxan compared to group of rats induced by alloxan and given soursop leaf extract     So it can be concluded that the administration of alloxan significantly increases the pancreatic tissue damage and the administration of soursop leaf extract can improve pancreatic tissue damage measured by histopathology score because soursop leaf extract contains flavonoids and tannins which function as antioxidants.</p><p> </p><p><strong>Keywords </strong>: Diabetes Melitus, Alloxan, Annona muricata Linn, Pancreatic Histopathology.</p>

Caffeic acid phenethyl ester as a protective agent against doxorubicin nephrotoxicity in rats

2004 ◽  
Vol 348 (1-2) ◽  
pp. 27-34 ◽  
Author(s):  
Murat Yagmurca ◽  
Hasan Erdogan ◽  
Mustafa Iraz ◽  
Ahmet Songur ◽  
Muharrem Ucar ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester ◽  
Protective Agent

Lycopene and Caffeic Acid Phenethyl Ester Affect Caspase-3 Activity, but Do Not Alter the NO Pathway in Lung Tissue Damage Induced by Cisplatin

Pharmacology ◽  
2021 ◽  
pp. 1-9
Author(s):  
Milan Rančić ◽  
Lidija Ristić ◽  
Andrija Rančić ◽  
Dane Krtinić ◽  
Bojan Ilić ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Lung Tissue ◽  
Tissue Damage ◽  
Protein Modification ◽  
Caspase 3 ◽  
Caffeic Acid Phenethyl Ester ◽  
Lung Damage ◽  
Myeloperoxidase Activity ◽  
Limited Effect ◽  
Lung Tissue Damage

<b><i>Introduction:</i></b> Antioxidants such as lycopene (LCP) and caffeic acid phenethyl ester (CAPE) represent ideal molecules for the treatment of different reactive oxygen species (ROS) associated disorders. Cisplatin is a chemotherapeutic agent, causing an increase in ROS and DNA damage, with numerous side effects, which include lung toxicity. In the presents study, we evaluated and mutually compared the potential of LCP and CAPE in preventing cisplatin-induced rat lung damage. <b><i>Methods:</i></b> The study was done using pathohistological analysis and a panel of biochemical parameters that reflect lung oxidative tissue damage, inflammation, and apoptosis. <b><i>Results:</i></b> The obtained results suggest that cisplatin (10 mg/kg) causes significant disturbances in the lung tissue morphology, followed by an increase in lipid peroxidization and protein modification. Also, a pronounced inflammatory response and cell apoptosis cascade activation was noted. Both LCP and CAPE were able to mitigate the changes, to a different extent, in oxidative damage and apoptosis progression induced by cisplatin. However, they both had limited effect on inflammation since they only prevented an increase in myeloperoxidase activity but had not been able to prevent the NO generation. <b><i>Conclusion:</i></b> It is hard to be exact in saying whether LCP or CAPE is better in preventing cis­platin-induced lung damage since they obviously possess different mechanisms of action.

scholarly journals Neuroprotective Effect of Intrastriatal Caffeic Acid Phenethyl Ester Treatment in 6-OH Dopamine Model of Parkinson’s Disease in Rats

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Burak Cem Soner ◽  
Eda Acikgoz ◽  
Salim Yalcin Inan ◽  
Sule Ayla ◽  
Ayse Saide Sahin ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Caffeic Acid ◽  
Neurodegenerative Disorder ◽  
Neuroprotective Effect ◽  
Caffeic Acid Phenethyl Ester ◽  
Adhesive Tape ◽  
Behavioral Studies ◽  
Male Wistar Rats ◽  
6 Hydroxydopamine

Parkinson’s disease (PD) is the second most common neurodegenerative disorder, and the main cause of PD is still not known. Until now, no cure for Parkinson’s disease is yet in sight. Caffeic acid phenethyl ester (CAPE) is a polyphenolic component of the propolis, which can be derived from honeybee hive propolis. We aimed to determine the effect of intrastriatal CAPE administration as a neuroprotective agent on 6-hydroxydopamine (6-OHDA)-induced PD model. Adult male Wistar rats weighing 280–320 g were used. The PD model was induced with unilateral intrastriatal 6-OHDA injection. Treatment groups received 20 μmol/5 μL/4 day and 80 μmol/5 μL/4 day CAPE 24 h after 6-OHDA injection. Eight days after 6-OHDA application, behavioral studies (adhesive tape removal test, open-field test, cylinder test, and apomorphine-induced asymmetric rotational behavior) were performed once more to compare the effects of CAPE on behavior tests. Striatal histological verifications, immunohistochemistry, and stereological quantitation were performed. Our results for the first time showed that, besides improving the motor performance, CAPE treatment also prevents 6-OHDA-induced loss of TH-positive neurons. From our results, CAPE may be a promising clinical agent in the treatment of PD.

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