Effects of an α blocking adrenergic, yohimbine and stress of contention on biochemical parameters in male rats (Rattus norvegicus)

2014 ◽  
Vol 47 (9) ◽  
pp. 768
Author(s):  
R. Chahira ◽  
L. Chanaz
Keyword(s):  
Rattus Norvegicus ◽  
Biochemical Parameters ◽  
Male Rats

Maternal restraint stress during pregnancy negatively affects behaviors and antioxidant capacity of offspring rats (Rattus norvegicus)

2018 ◽  
Vol 96 (8) ◽  
pp. 882-887 ◽  
Author(s):  
Chao Yin ◽  
Guofu Wang ◽  
Shixing Gao ◽  
Yanping Huang ◽  
Ruqian Zhao ◽  
...  
Keyword(s):  
Antioxidant Capacity ◽  
Soleus Muscle ◽  
Rattus Norvegicus ◽  
Biochemical Parameters ◽  
Restraint Stress ◽  
Gastrocnemius Muscle ◽  
Female Offspring ◽  
Female Rats ◽  
Male Rats ◽  
Biochemical Indices

This study evaluated the effect of maternal restraint stress during the gestation period on behaviors, biochemical parameters, and antioxidant capacities of offspring rats (Rattus norvegicus (Berkenhout,1769)) at weaning age. Behaviors, plasma biochemical indices, and antioxidant ability of the liver, soleus muscle, and gastrocnemius muscle of mother and (or) offspring rats were analyzed. Significant increases were found in the immobility and swinging behavior frequencies of offspring male rats; no difference was found in behaviors of female rats. The antioxidant indices including superoxide dismutase, nitric oxide synthase, and total antioxidant capacity in the soleus muscle of offspring male rats were significantly decreased in the restraint group. Female offspring rats showed significant lower glutathione and higher malondialdehyde levels in the gastrocnemius muscle and liver, respectively. No difference was found in the productive performance and plasma biochemical indices of maternal rats, nor in the biochemical parameters of the two groups of weaning rats. The results suggested that maternal chronic stresses negatively affected the behaviors and antioxidant abilities of offspring rats, and that these effects possibly have a greater impact on offspring male rats than on female rats.

scholarly journals The effect of Tramadol on some blood and biochemical parameters of male rats (Rattus norvegicus)

2015 ◽  
Vol 12 (3) ◽  
pp. 496-502
Author(s):  
Baghdad Science Journal
Keyword(s):  
Rattus Norvegicus ◽  
Biochemical Parameters ◽  
Experimental Period ◽  
Treated Group ◽  
Blood Film ◽  
Male Rats ◽  
High Dose ◽  
Hematological And Biochemical Parameters ◽  
Wbc Count ◽  
Dose Dependent

The present study aimed to explain the dose-dependent possible deleterious effects of 30 day administration of Tramadol on some hematological and biochemical parameters of laboratory male rats (Rattus norvegicus), the study consisted of eighteen adult male rats randomly divided into three equal groups (each of six). Group 1 (control) were treated by intraperitoneal injection of normal saline solution (0.2 ml), group two (low dose) was treated by intraperitonealy (i.p) injection of Tramadol at a dose of 50 mg/kg/day, group three (high dose) was treated by intraperitonealy injection of Tramadol at a dose of 100 mg/kg/day for 30 days. At the end of experimental period, rats were sacrificed. Blood were collected by cardiac puncture to investigate blood film and biochemical parameters which include Aspartate transaminase (AST), Alanine transaminase (ALT), urea, and glucose. Results explained a significant reduction in hemoglobin (Hb), packed cell volume (PCV), and red blood cells count (RBC), in both treated group and significant elevation in WBC count which is clearly appeared in lymphocyte count, while the biochemical results showed a significant increased in ALT, blood urea, and decreased in blood glucose level in high dose treated group mostly

Effects of paroxitine on biochemical parameters and reproductive function in male rats

2019 ◽  
Author(s):  
Rachid Mosbah ◽  
Aziz Chettoum ◽  
Zohir Djerrou ◽  
Alberto Mantovani
Keyword(s):  
Biochemical Parameters ◽  
Reproductive Function ◽  
Male Rats

scholarly journals Effects of peptidic growth hormone secretagogue receptor (GHS-R) antagonist [D-Lys3] on some of serum hormonal and biochemical parameters in Wistar rat model

2014 ◽  
Vol 58 (3) ◽  
pp. 288-291 ◽  
Author(s):  
Habib Aghdam Shahryar ◽  
Alireza Lotfi
Keyword(s):  
Total Protein ◽  
Biochemical Parameters ◽  
Serum Lipids ◽  
Considerable Increase ◽  
Wistar Rat ◽  
Male Rats ◽  
Growth Hormone Secretagogue Receptor ◽  
Growth Hormone Secretagogue ◽  
Glucose Levels ◽  
Blood Glucose Levels

Objective : The present study investigated the effects of different dosages of a GHS-R antagonist [D-Lys3] on some serum hormonal (cortisol, T3 and T4) and biochemical parameters in a rat.Materials and methods : Thirty-six 60-day-old male rats were assigned to four treatments. [D-Lys3]-GHRP-6 solutions were infused via intraperitoneal injections. Blood was collected and analyzed.Results : The large dosages of a GHS-R antagonist (200 ng/kg BW) caused increases in cortisol, whereas no significant changes occurred when low dosages were injected. There were no significant changes in T3 and T4 following the administration of the GHS-R antagonist, but a considerable increase was observed in blood glucose levels of the groups (G50, G100, and G200 ng/kg BW). There was a significant increase in total protein when the greatest dose was administrated (G200 ng/kg BW). However, total cholesterol, triglycerides, and albumin showed no significant changes.Conclusions : Exogenous GHS-R antagonist can cause an increase in glucose and moderate increases in cortisol and total protein, yet it has no significant effect on T3 and T4 levels or on the concentrations of serum lipids. The effect of GHS-R antagonist is not completely adverse to the effects of ghrelin. Further molecular studies are necessary to identify the physiological effects of the peptidic GHS-R antagonist. Arq Bras Endocrinol Metab. 2014;58(3):288-91

scholarly journals UJI AKTIVITAS ANTIPIRETIK EKSTRAK ETANOL DAUN JARAK PAGAR (Jatropha curcas L.) PADA TIKUS PUTIH JANTAN (Rattus norvegicus) GALUR WISTAR YANG DIINDUKSI VAKSIN DPT

PHARMACON ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 342
Author(s):  
Angel T. Gosal ◽  
Edwin De Queljoe ◽  
Elly J. Suoth
Keyword(s):  
Vitamin C ◽  
Jatropha Curcas ◽  
Rattus Norvegicus ◽  
Ethanol Extract ◽  
Positive Control ◽  
Male Rats ◽  
Anova Analysis ◽  
Jatropha Curcas L ◽  
Antipyretic Activity ◽  
Wistar Male Rats

ABSTRACTJatropha curcas L. leaves is plants containing saponins, flavonoid compounds such as kaempferol, nicotoflorin, quersitin, astragalin, ricinin and vitamin C. Flavonoids showed more than one hundred kinds of bioactivity, which is antipyretic, analgesic and anti-inflammatory effects. Several researches informed that flavonoid compound had antipyretic activity. The aim of this study was to examined the effect of ethanolic extract of Jatropha curcas L. leaves as antipyretic on white Wistar male rats (Rattus norvegicus) induced with DPT. There were 15 rats tested, divided into 5 groups that is negative control (CMC 1%), positive control (paracetamol) and treatment group of physic nut leaves extract 200 mg, 400 mg and 800 mg. Every rat was induced by fever using 0,4 ml of DPT vaccine intramuscularly. The temperature was measured before the rats were induced, 2-3 hour after induced and every 30 minute for 3 hours. The data obtained were analyzed by ANOVA (Analysis of Variants) and LSD. The results showed that the dose group of Jatropha curcas L. leaves ethanol extract had comparable activity with positive control of paracetamol in reducing fever. The conclusion was the ethanol extract of Jatropha curcas L. leaves has an antipyretic activity that could reduce temperature on white Wistar male rats at a dose of 200 mg, 400 mg and 800 mg. Keywords: Jatropha curcas L., antipyretic, Rattus norvegicus ABSTRAKDaun Jarak Pagar (Jatropha curcas L.) merupakan tanaman yang mengandung saponin, senyawa flavonoida antara lain kaempferol, nikotoflorin, kuersitin, astragalin, risinin dan vitamin C. Flavonoid menunjukkan lebih dari seratus macam bioaktivitas, antara lain efek antipiretik, analgetik dan antiinflamasi. Penelitian ini bertujuan untuk menguji aktivitas antipiretik ekstrak etanol daun jarak pagar (Jatropha curcas L.) terhadap tikus putih jantan galur wistar (Rattus norvegicus) yang diinduksi vaksin DPT. Hewan uji yang digunakan sebanyak 15 ekor dan dibagi menjadi 5 kelompok yaitu kontrol negatif (CMC 1%), kontrol positif (parasetamol) dan kelompok dosis uji yaitu pemberian ekstrak daun jarak pagar 200 mg, 400 mg dan 800 mg. Setiap tikus diinduksi demam dengan vaksin DPT dosis 0,4 ml secara intramuskular. Pengukuran suhu dilakukan sebelum induksi, 2-3 jam setelah pemberian induksi dan setiap 30 menit selama 3 jam. Data yang diperoleh dianalisis dengan menggunakan uji ANOVA (Analysis of Variance) dan uji LSD (Least Significant Different). Hasil penelitian menunjukkan bahwa kelompok dosis ekstrak etanol daun jarak pagar memiliki aktivitas yang sebanding dengan kontrol positif parasetamol dalam menurunkan demam. Kesimpulannya ekstrak etanol daun jarak pagar (Jatropha curcas L.) memiliki aktivitas antipiretik yang dapat menurunkan suhu tubuh pada tikus putih jantan galur wistar (Rattus norvegicus) pada dosis 200 mg, 400 mg dan 800 mg. Kata kunci: Jatropha curcas L., antipiretik, Rattus norvegicus

scholarly journals The Effect of Balimo (Zanthoxylum nitidum) Immersion Water On The Hematological Profile of White Rats (Rattus norvegicus) That Given Liquor (Ciu)

2021 ◽  
Vol 10 (1) ◽  
pp. 47-57
Author(s):  
Panca Buana Wijaya ◽  
Tyas Rini Saraswati ◽  
Silvana Tana ◽  
Sunarno Sunarno ◽  
Erma Prihastanti
Keyword(s):  
Rattus Norvegicus ◽  
Male Rats ◽  
Excessive Alcohol Consumption ◽  
White Rats ◽  
Excessive Alcohol ◽  
The Mean ◽  
Zanthoxylum Nitidum ◽  
The Difference ◽  
Antioxidant Effects ◽  
One Way Anova

Consumption of liquor such as Ciu in excessive doses can cause a decrease in hematological status. Balimo stem is an alternative treatment to improve hematological status due to excessive alcohol consumption because it contains alkaloids, flavonoids, and other secondary metabolic compounds, that have functions as antioxidant effects. This study aims to examine and analyze the effect of Balimo immersion water on the hematological status of mice with the observed variables, namely the erythrocytes count, hemoglobin levels, hematocrit value, and total count of leukocytes in rats that had been given Ciu. The study used 20 Rattus norvegicus male rats which were divided into 4 groups. The data were analyzed using one-way ANOVA. The results showed no significant differences (p <0.05) on the Balimo immersion water treatment, but if it was seen from the difference in the mean data of each variable, it could still be seen the difference from each treatment. In this study, it can be concluded that Balimo immersion water was able to improve the hematological status of rats that had been given Ciu liquor with a 0,2 mL dose.

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