FV 4. Contribution of Wada test results to the prediction of change in verbal learning and memory function after epilepsy surgery in the temporal lobe

2021 ◽  
Vol 132 (8) ◽  
pp. e30-e31
Author(s):  
N. Conradi ◽  
F. Rosenberg ◽  
S. Knake ◽  
L. Biermann ◽  
A. Haag ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Temporal Lobe ◽  
Epilepsy Surgery ◽  
Memory Function ◽  
Verbal Learning ◽  
Test Results ◽  
Wada Test

scholarly journals Wada test results contribute to the prediction of change in verbal learning and verbal memory function after temporal lobe epilepsy surgery

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Nadine Conradi ◽  
Friederike Rosenberg ◽  
Susanne Knake ◽  
Louise Biermann ◽  
Anja Haag ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Epilepsy Surgery ◽  
Verbal Memory ◽  
Prediction Models ◽  
Memory Function ◽  
Verbal Learning ◽  
Wada Test ◽  
Incremental Value ◽  
Neuropsychological Characteristics

AbstractIn recent years, the clinical usefulness of the Wada test (WT) has been debated among researchers in the field. Therefore, we aimed to assess its contribution to the prediction of change in verbal learning and verbal memory function after epilepsy surgery. Data from 56 patients with temporal lobe epilepsy who underwent WT and subsequent surgery were analyzed retrospectively. Additionally, a standard neuropsychological assessment evaluating attentional, learning and memory, visuospatial, language, and executive function was performed both before and 12 months after surgery. Hierarchical linear regression analyses were used to determine the incremental value of WT results over socio-demographic, clinical, and neuropsychological characteristics in predicting postsurgical change in patients’ verbal learning and verbal memory function. The incorporation of WT results significantly improved the prediction models of postsurgical change in verbal learning (∆R2 = 0.233, p = .032) and verbal memory function (∆R2 = 0.386, p = .005). Presurgical performance and WT scores accounted for 41.8% of the variance in postsurgical change in verbal learning function, and 51.1% of the variance in postsurgical change in verbal memory function. Our findings confirm that WT results are of significant incremental value for the prediction of postsurgical change in verbal learning and verbal memory function. Thus, the WT contributes to determining the risks of epilepsy surgery and, therefore, remains an important part of the presurgical work-up of selected patients with clear clinical indications.

scholarly journals Seizure Freedom After Epilepsy Surgery and Higher Baseline Cognition May Be Associated With a Negatively Correlated Epilepsy Network in Temporal Lobe Epilepsy

2021 ◽  
Vol 14 ◽  
Author(s):  
Elliot G. Neal ◽  
Mike R. Schoenberg ◽  
Stephanie Maciver ◽  
Yarema B. Bezchlibnyk ◽  
Fernando L. Vale
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Epilepsy Surgery ◽  
Memory Function ◽  
Brain Regions ◽  
Seizure Freedom ◽  
Epileptogenic Zone ◽  
Temporal Lobes ◽  
Scalp Eeg ◽  
The Brain

Background: Brain regions positively correlated with the epileptogenic zone in patients with temporal lobe epilepsy vary in spread across the brain and in the degree of correlation to the temporal lobes, thalamus, and limbic structures, and these parameters have been associated with pre-operative cognitive impairment and seizure freedom after epilepsy surgery, but negatively correlated regions have not been as well studied. We hypothesize that connectivity within a negatively correlated epilepsy network may predict which patients with temporal lobe epilepsy will respond best to surgery.Methods: Scalp EEG and resting state functional MRI (rsfMRI) were collected from 19 patients with temporal lobe epilepsy and used to estimate the irritative zone. Using patients’ rsfMRI, the negatively correlated epilepsy network was mapped by determining all the brain voxels that were negatively correlated with the voxels in the epileptogenic zone and the spread and average connectivity within the network was determined.Results: Pre-operatively, connectivity within the negatively correlated network was inversely related to the spread (diffuseness) of that network and positively associated with higher baseline verbal and logical memory. Pre-operative connectivity within the negatively correlated network was also significantly higher in patients who would go on to be seizure free.Conclusion: Patients with higher connectivity within brain regions negatively correlated with the epilepsy network had higher baseline memory function, narrower network spread, and were more likely to be seizure free after surgery.

Parahippocampal and Entorhinal Resection Extent Predicts Verbal Memory Decline in an Epilepsy Surgery Cohort

2017 ◽  
Vol 29 (5) ◽  
pp. 869-880 ◽  
Author(s):  
Anli Liu ◽  
Thomas Thesen ◽  
William Barr ◽  
Chris Morrison ◽  
Patricia Dugan ◽  
...  
Keyword(s):  
Free Recall ◽  
Learning And Memory ◽  
Temporal Lobe ◽  
Verbal Learning ◽  
Critical Role ◽  
Anterior Temporal Lobe ◽  
Short Delay ◽  
Memory Change ◽  
Baseline Performance ◽  
Temporal Lobe Resection

The differential contribution of medial-temporal lobe regions to verbal declarative memory is debated within the neuroscience, neuropsychology, and cognitive psychology communities. We evaluate whether the extent of surgical resection within medial-temporal regions predicts longitudinal verbal learning and memory outcomes. This single-center retrospective observational study involved patients with refractory temporal lobe epilepsy undergoing unilateral anterior temporal lobe resection from 2007 to 2015. Thirty-two participants with Engel Class 1 and 2 outcomes were included (14 left, 18 right) and followed for a mean of 2.3 years after surgery (±1.5 years). Participants had baseline and postsurgical neuropsychological testing and high-resolution T1-weighted MRI scans. Postsurgical lesions were manually traced and coregistered to presurgical scans to precisely quantify resection extent of medial-temporal regions. Verbal learning and memory change scores were regressed on hippocampal, entorhinal, and parahippocampal resection volume after accounting for baseline performance. Overall, there were no significant differences in learning and memory change between patients who received left and right anterior temporal lobe resection. After controlling for baseline performance, the extent of left parahippocampal resection accounted for 27% (p = .021) of the variance in verbal short delay free recall. The extent of left entorhinal resection accounted for 37% (p = .004) of the variance in verbal short delay free recall. Our findings highlight the critical role that the left parahippocampal and entorhinal regions play in recall for verbal material.

scholarly journals Smoking Impairs Womens Verbal Learning and Memory Performance More than Mens: An International Web-Cohort Study of 70,000 Participants

2020 ◽  
Author(s):  
Candace Lewis ◽  
Joshua Siegfried Talboom ◽  
Matt D De Both ◽  
Annie M Schmidt ◽  
Marcus A Naymik ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cognitive Impairment ◽  
Learning And Memory ◽  
Verbal Memory ◽  
Memory Performance ◽  
Memory Function ◽  
Verbal Learning ◽  
Learning Performance ◽  
Permutation Testing ◽  
The Impact

Background: Vascular contributions to cognitive impairment and dementia (VCID) include structural and functional blood vessel injuries linked to poor neurocognitive outcomes. Smoking might indirectly increase the likelihood of cognitive impairment by exacerbating the risks associated with underlying vascular disease. Sex disparities in VCID have been reported, however, few studies have assessed the sex-specific impact of smoking on cognitive function and with contradictory results. This is an important topic since smoking and cardiovascular disease negatively impact health and possibly women have the greater lifetime risk of stroke and dementia than men. In this study, we sought to investigate the effect-modification of sex on the relationship between smoking, cardiovascular disease and verbal learning and memory function. Methods: Using MindCrowd, a web-based cohort of over 70,000 people aged 18 - 85, we investigated whether sex modifies the impact of smoking and cardiovascular disease on verbal memory performance on a paired-associate learning task using both multiple regression and propensity matching approaches. Artificial error introduction and permutation testing underscored the stability of our results. To demonstrate the necessity of large sample sizes to detect an interaction of sex and smoking, we performed down sampling analyses. Findings: We found significant interactions in that smoking impacts verbal learning performance more in women and cardiovascular disease more in men across a wide age range. Interpretation: These results suggest that smoking and cardiovascular disease impact verbal learning and memory throughout adulthood. Smoking particularly affects learning and memory in women and cardiovascular disease has a larger effect in men. Although the reasons for these sex-modification effects are not entirely understood, our findings highlight the importance of considering biological sex in VCID.

Memory Function and Verbal Learning Ability in Patients with Complex Partial Seizures of Temporal Lobe Origin

Epilepsia ◽  
1987 ◽  
Vol 28 (5) ◽  
pp. 547-554 ◽  
Author(s):  
Bruce P. Hermann ◽  
Allen R. Wyler ◽  
E. T. Richey ◽  
Jeanne M. Rea
Keyword(s):  
Temporal Lobe ◽  
Memory Function ◽  
Verbal Learning ◽  
Learning Ability ◽  
Partial Seizures ◽  
Complex Partial Seizures

scholarly journals Human temporal lobe potentials in verbal learning and memory processes

1997 ◽  
Vol 35 (5) ◽  
pp. 657-667 ◽  
Author(s):  
Christian E Elger ◽  
Thomas Grunwald ◽  
Klaus Lehnertz ◽  
Marta Kutas ◽  
Christoph Helmstaedter ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Temporal Lobe ◽  
Verbal Learning ◽  
Memory Processes ◽  
Human Temporal Lobe

scholarly journals Depression and Temporal Lobe Epilepsy: Expression Pattern of Calbindin Immunoreactivity in Hippocampal Dentate Gyrus of Patients Who Underwent Epilepsy Surgery with and without Comorbid Depression

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Luciana D’Alessio ◽  
Hector Konopka ◽  
Patricia Solís ◽  
Laura Scévola ◽  
Mónica Fernandez Lima ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Dentate Gyrus ◽  
Temporal Lobe ◽  
Epilepsy Surgery ◽  
Verbal Learning ◽  
Granular Cell ◽  
Cell Loss ◽  
Comorbid Depression ◽  
Hippocampal Dentate Gyrus ◽  
Dsm Iv

Purpose. Changes in calbindin (CB) expression have been reported in patients with temporal lobe epilepsy (TLE) with controversial implications on hippocampal functions. The aim of this study was to determine the CB immunoreactivity in hippocampal dentate gyrus of patients who underwent epilepsy surgery for drug-resistant TLE with and without comorbid depression and/or memory deficits. Methods. Selected hippocampal samples from patients with TLE who underwent epilepsy surgery were included. Clinical and complementary assessment: EEG, video-EEG, MRI, psychiatric assessment (structured clinical interview, DSM-IV), and memory assessment (Rey auditory verbal learning test, RAVLT; Rey-Osterrieth complex figure test, RCFT), were determined before surgery. Hippocampal sections were processed using immunoperoxidase with the anti-calbindin antibody. The semiquantitative analysis of CB immunoreactivity was determined in dentate gyrus by computerized image analysis (ImageJ). Results. Hippocampal sections of patients with TLE and HS (n=24) and postmortem controls (n=5) were included. A significant reduction of CB+ cells was found in patients with TLE (p<0.05, Student’s t-test). Among TLE cases (n=24), depression (n=12) and memory deficit (n=17) were determined. Depression was associated with a higher % of cells with the CB dendritic expression (CB-sprouted cells) (F1,20=11.81, p=0.003, hp2=0.37), a higher CB+ area (μm2) (F1,20=5.33, p=0.032, hp2=0.21), and a higher optical density (F1,20=15.09, p=0.001, hp2=0.43) (two-way ANOVA). The GAF scale (general assessment of functioning) of DSM-IV inversely correlated with the % of CB-sprouted cells (r=−0.52, p=0.008) and with the CB+ area (r=−0.46, p=0.022). Conclusions. In this exploratory study, comorbid depression was associated with a differential pattern of CB cell loss in dentate gyrus combined with a higher CB sprouting. These changes may indicate granular cell dysmaturation associated to the epileptic hyperexcitability phenomena. Further investigations should be carried out to confirm these preliminary findings.

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