Comment on "Effects of adequate dietary protein with whey protein, leucine, and vitamin D supplementation on sarcopenia in older adults: An open-label, parallel-group study "

2021 ◽  
Author(s):  
Deniz Sevindik Günay ◽  
Umut Safer ◽  
Vildan Binay Safer
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Whey Protein ◽  
Dietary Protein ◽  
Vitamin D Supplementation ◽  
Open Label ◽  
Parallel Group Study ◽  
Parallel Group

Whey protein and vitamin D supplementation in institutionalized older adults: A randomized trial

2021 ◽  
pp. 026010602110606
Author(s):  
Tamy Colonetti ◽  
Antônio Jose Grande ◽  
Franciani Rodrigues da Rocha ◽  
Eduardo Ronconi Dondossola ◽  
Lisiane Tuon ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Body Composition ◽  
Resistance Training ◽  
Whey Protein ◽  
Muscle Mass ◽  
Lean Mass ◽  
Vitamin D Supplementation ◽  
Relative Index ◽  
And Control

Background: The increase in life expectancy and in the number of individuals over 60 years old brings new demands to health professionals and services based on the physiological changes that occur in this population. The aging process results in changes in body composition, increasing body fat and reducing muscle mass, in addition to a reduction in bone mass. Aim: The aim of this study was to examine the effect of whey protein and vitamin D supplementation on body composition and skeletal muscle in older adults living in long-term care facilities. Methods: This study is a double-blind randomized controlled trial. Thirty older adults (>60 years old) were randomized and allocated in three groups: group receiving resistance training and supplementation receiving resistance training, whey protein and vitamin D; group received resistance and placebo training receiving resistance training and placebo, and control group without any intervention. Body composition was measured by dual-energy X-ray absorptiometry at baseline, 12 weeks, and 24 weeks. Results: The mean age was 74.87 (± 8.14) years. A significant difference ( p = 0.042) was observed between the group receiving resistance training and supplementation and control groups in relation to lean mass increase (kg) at 24 weeks. After 24 weeks of intervention, there was a significant increase in Relative index of muscle mass for the two groups that underwent resistance training, group received resistance and placebo training ( p = 0.042) and group receiving resistance training and supplementation ( p = 0.045), in relation to the control. Conclusion: Combined supplementation of whey protein and vitamin D with resistance training can significantly improve lean mass, total mass, and relative index of muscle mass in institutionalized older adults.

scholarly journals Safety and tolerability of 6-month supplementation with a vitamin D, calcium and leucine-enriched whey protein medical nutrition drink in sarcopenic older adults

2020 ◽  
Vol 32 (8) ◽  
pp. 1501-1514 ◽  
Author(s):  
Jürgen M. Bauer ◽  
◽  
Lucia Mikušová ◽  
Sjors Verlaan ◽  
Ivan Bautmans ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Whey Protein ◽  
Kidney Function ◽  
Controlled Trial ◽  
Test Group ◽  
Serum Levels ◽  
Open Label ◽  
Moderate Chronic Kidney Disease ◽  
Medical Nutrition

Abstract Aims Safety and tolerability of prolonged supplementation with a vitamin D, calcium and leucine-enriched whey protein medical nutrition drink (WP-MND) was evaluated in sarcopenic older adults. Methods A 13-week double-blinded, randomized, isocaloric placebo-controlled trial (PROVIDE study; n = 380) was extended with a voluntary 13-week open-label extension (OLE). OLE participants were randomized to receive daily 1 or 2 servings of WP-MND (21 g protein, 3 g leucine, 10 µg vitD and 500 mg calcium per serving). Gastro-intestinal tolerability, kidney function and serum levels of calcidiol, parathyroid hormone (PTH) and calcium were evaluated at week 0, 13 and 26. Results and discussion In response to the high daily protein intake (median1.5; IQR: 1.3, 1.7 g/kg BW/day), the estimated glomerular filtration rate (eGFR) increased in the test group during the RCT (p = 0.013). The same trend was observed for those participants with moderate chronic kidney disease. During OLE no eGFR change was observed in any of the groups. Serum calcidiol and calcium reached a plateau after 13-week WP-MND supplementation. As expected, PTH significantly changed in the opposite direction, decreasing during RCT in the test group (T vs C: p < 0.001) and during OLE in former control groups. During RCT, 20/366 participants with normal baseline calcidiol reached levels ≥ 100 nmol/L (T: n = 18; C: n = 2) and 6 developed albumin-corrected calcium levels > 2.55 mmol/L (T: n = 3; C: n = 3), without associated adverse events. Conclusion A 6 months intervention with up to 2 servings of WP-MND did neither result in kidney function deterioration nor symptoms of vitamin D or calcium toxicity. The product was overall well tolerated.

scholarly journals Vitamin D and Hospital Admission in Older Adults: A Prospective Association

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 616
Author(s):  
Avril Beirne ◽  
Kevin McCarroll ◽  
James Bernard Walsh ◽  
Miriam Casey ◽  
Eamon Laird ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Hospital Admission ◽  
Cross Sectional Study ◽  
Vitamin D Supplementation ◽  
Inverse Association ◽  
Cross Sectional ◽  
Prospective Association ◽  
Randomised Controlled

The health effects of vitamin D are well documented, with increasing evidence of its roles beyond bone. There is, however, little evidence of the effects of vitamin D on hospitalisation among older adults. This study aimed to prospectively determine the relationship of vitamin D status in older adults with hospital admission and emergency department (ED) attendance. Trinity University of Ulster Department of Agriculture (TUDA) is a large cross-sectional study of older adults with a community population from three disease-defined cohorts (cognitive dysfunction, hypertension, and osteoporosis). Participants included in this analysis were recruited between 2008 and 2012. ED and hospital admission data were gathered from the date of TUDA participation until June 2013, with a mean follow up of 3.6 years. Of the 3093 participants, 1577 (50.9%) attended the ED during the period of follow-up. Attendees had lower mean serum 25(OH)D concentrations than non-attendees (59.1 vs. 70.6 nmol/L). Fully adjusted models showed an inverse association between vitamin D and ED attendance (Hazard Ratio (HR) 0.996; 95% Confidence Interval (CI) 0.995–0.998; p < 0.001). A total of 1269 participants (41%) were admitted to hospital during the follow-up. Those admitted had lower mean vitamin D concentrations (58.4 vs. 69.3 nmol/L, p < 0.001). In fully adjusted models, higher vitamin D was inversely associated with hospital admission (HR 0.996; 95% CI 0.994–0.998; p < 0.001) and length of stay (LOS) (β = −0.95, p = 0.006). This study showed independent prospective associations between vitamin D deficiency and increased hospitalisation by older adults. The need for further evaluation of current recommendations in relation to vitamin D supplementation, with consideration beyond bone health, is warranted and should focus on randomised controlled trials.

scholarly journals Effect of an interactive text-messaging service on patient retention during the first year of HIV care in Kenya (WelTel Retain): an open-label, randomised parallel-group study

2018 ◽  
Vol 3 (3) ◽  
pp. e143-e152 ◽  
Author(s):  
Mia Liisa van der Kop ◽  
Samuel Muhula ◽  
Patrick I Nagide ◽  
Lehana Thabane ◽  
Lawrence Gelmon ◽  
...  
Keyword(s):  
Text Messaging ◽  
Hiv Care ◽  
First Year ◽  
Open Label ◽  
Parallel Group Study ◽  
Parallel Group ◽  
Interactive Text ◽  
Patient Retention

MP680THE EFFECT OF VITAMIN D SUPPLEMENTATION ON RESPONSE TO HEPATITIS B VACCINATION IN DIALYSIS PATIENTS - AN OPEN LABEL PILOT STUDY

2017 ◽  
Vol 32 (suppl_3) ◽  
pp. iii681-iii681
Author(s):  
Hildegard Hafner-Giessauf ◽  
Sabine Horn ◽  
Hannelore Sprenger-Maehr ◽  
Kathrin Eller ◽  
Alexander Rosenkranz ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pilot Study ◽  
Hepatitis B ◽  
Vitamin D Supplementation ◽  
Hepatitis B Vaccination ◽  
Dialysis Patients ◽  
Open Label

scholarly journals Effect of vitamin D supplementation on thyroid autoimmunity among subjects of autoimmune thyroid disease in a coastal province of India: A randomized open-label trial

2020 ◽  
Vol 61 (5) ◽  
pp. 237
Author(s):  
KishoreKumar Behera ◽  
GautomKumar Saharia ◽  
Debasish Hota ◽  
DurgeshPrasad Sahoo ◽  
Madhusmita Sethy ◽  
...  
Keyword(s):  
Vitamin D ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Thyroid Autoimmunity ◽  
Vitamin D Supplementation ◽  
Open Label ◽  
Autoimmune Thyroid ◽  
Coastal Province ◽  
Open Label Trial

scholarly journals Effects of vitamin D supplementation on red cell indices and cytokines in patients with thalassemia: An open-label randomized clinical trial

2019 ◽  
pp. 170-179
Keyword(s):  
Clinical Trial ◽  
Vitamin D ◽  
Randomized Clinical Trial ◽  
Thalassemia Major ◽  
Vitamin D Supplementation ◽  
Beta Thalassemia ◽  
Red Cell ◽  
Open Label ◽  
Hematological Indices ◽  
Red Cell Indices

Background and aim Deficiency of vitamin D is known as a health problem all over the world and a recognized clinical complication of beta thalassemia patients. Vitamin D acts as a hormone at the nuclear receptor rendering it a beneficial medication for a number of diseases. It is believed that vitamin D is important in the modulation of the inflammation system by regulating the formation of inflammatory cytokines and immune cells. This study aimed to investigate the effect of vitamin D supplementation on the red cell indices and cytokines levels in patients with beta thalassemia major, in an open label randomized clinical trial. Patients and Methods: this study performed an open-label randomized clinical trial in patients with beta thalassemia major. Forty-six patients completed the eight weeks clinical trial and were allocated to administer oral vitamin D3 supplement of 100,000 IU every two weeks as an add-on treatment. During the study, hematological indices, serum iron, ferritin, vitamin D, calcium and inflammatory markers (interleukin-6, interleukin-2 and interleukin-10) were evaluated before (at baseline) and after vitamin D supplementation for 8 weeks. Results: Vitamin D3 supplements significantly decreases interleukin-6 levels and elevates the serum levels of anti-inflammatory cytokines IL-2 and IL-10, it also significantly reduced serum ferritin level, but it did not alter the hematological indices. Conclusion: Our results suggest that administration of vitamin D has a potential anti-inflammatory role in beta thalassemia patients and reduces serum ferritin levels, which may reduce the burdens of iron overload in thalassemia patients.

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