Designing for Sustainability with Biocatalytic and Chemoenzymatic Cascade Processes

LncRNAs (long non-coding RNAs) are endogenous molecules, involved in complicated biological processes. Increasing evidence has shown that lncRNAs play a vital role in the post-stroke pathophysiology. Furthermore, several lncRNAs were reported to mediate ischemia cascade processes include apoptosis, bloodbrain barier breakdown, angiogenesis, microglial activation induced neuroinflammation which can cause neuron injury and influence neuron recovery after ischemic stroke. In our study, we first summarize current development about lncRNAs and post-stroke, focus on the regulatory roles of lncRNAs on pathophysiology after stroke. We also reviewed genetic variation in lncRNA associated with functional outcome after ischemic stroke. Additionally, lncRNA-based therapeutics offer promising strategies to decrease brain damage and promote neurological recovery following ischemic stroke. We believe that lncRNAs will become promising for the frontier strategies for IS and can open up a new path for the treatment of IS in the future.

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Spectral cascade processes in electron-acoustic mode turbulence

Physics Letters A ◽

10.1016/0375-9601(82)90134-7 ◽

1982 ◽

Vol 89 (1) ◽

pp. 13-15 ◽

Cited By ~ 2

Author(s):

H.U Rahman ◽

P.K Shukla

Keyword(s):

Acoustic Mode ◽

Cascade Processes ◽

Electron Acoustic

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Cascade processes of stimulated wave scattering in bounded nonlinear media

Radiophysics and Quantum Electronics ◽

10.1007/bf01040725 ◽

1985 ◽

Vol 28 (11) ◽

pp. 999-1008

Author(s):

G. V. Permitin ◽

V. I. Petrukhina ◽

I. V. Khazanov

Keyword(s):

Wave Scattering ◽

Nonlinear Media ◽

Cascade Processes

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Ratio limit theorems for cascade processes

Zeitschrift für Wahrscheinlichkeitstheorie und Verwandte Gebiete ◽

10.1007/bf00531682 ◽

1964 ◽

Vol 3 (1) ◽

pp. 32-49 ◽

Cited By ~ 3

Author(s):

P. E. Ney

Keyword(s):

Limit Theorems ◽

Cascade Processes ◽

Ratio Limit Theorems ◽

Ratio Limit

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New Cascade Processes on Group 6 Fischer-Type Carbene Complexes: Cyclopropanation and Metathesis Reactions

Organic Letters ◽

10.1021/ol701604g ◽

2007 ◽

Vol 9 (21) ◽

pp. 4143-4146 ◽

Cited By ~ 30

Author(s):

José Barluenga ◽

Facundo Andina ◽

Fernando Aznar ◽

Carlos Valdés

Keyword(s):

Carbene Complexes ◽

Group 6 ◽

Metathesis Reactions ◽

Cascade Processes

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Recent advances in cyclohydrocarbonylation reactions

Canadian Journal of Chemistry ◽

10.1139/v05-035 ◽

2005 ◽

Vol 83 (6-7) ◽

pp. 681-692 ◽

Cited By ~ 20

Author(s):

Wen-Hua Chiou ◽

Seung-Yub Lee ◽

Iwao Ojima

Keyword(s):

Transition Metal Complexes ◽

Relevant Literature ◽

Cascade Process ◽

One Pot ◽

Polycyclic Compounds ◽

Carbon Nucleophiles ◽

Recent Advances ◽

Carbocyclic Compounds ◽

Cascade Processes ◽

One Step

This article describes recent advances in the cyclohydrocarbonylation reactions catalyzed by transition-metal complexes and their applications in organic synthesis as a review covering the relevant literature up to the middle of 2004. The reactions are categorized into four types, i.e., intramolecular amidocarbonylation reactions, intramolecular aminocarbonylation reactions, cyclohydrocarbonylation reactions involving carbonnucleophiles, and other cyclohydrocarbonylation reactions. Cyclohydrocarbonylation reactions provide efficient routes to various monocyclic, bicyclic, and polycyclic compounds as a one-step cascade process or a one-pot process. Reaction mechanisms for these cascade processes are discussed as needed for clarification. The heterocyclic and carbocyclic compounds, thus obtained, can be further transformed to specific targets. Examples of such applications are also discussed.Key words: catalysis, cyclohydrocarbonylation, hydroformylation, amidocarbonylation, cyclization, regioselectivity, aldehydes, regioselective, cascade, heterocycles, rhodium.

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Reactions of Acylpalladium Derivatives with Oxygen, Nitrogen, and Other Group 15, 16, and 17 Atom Nucleophiles: Tandem and Cascade Processes Terminated by Carbonylative Esterification, Amidation, and Related Reactions

Handbook of Organopalladium Chemistry for Organic Synthesis ◽

10.1002/0471212466.ch105 ◽

2005 ◽

pp. 2377-2397 ◽

Cited By ~ 1

Author(s):

Hans-Günther Schmalz ◽

Oliver Geis

Keyword(s):

Group 15 ◽

Cascade Processes

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1.11 Generation of Radicals from Organoboranes

Free Radicals: Fundamentals and Applications in Organic Synthesis 1 ◽

10.1055/sos-sd-234-00224 ◽

2021 ◽

Author(s):

E. André-Joyaux ◽

L. Gnägi ◽

C. Melendez ◽

V. Soulard ◽

P. Renaud

Keyword(s):

Organic Synthesis ◽

Coupling Reactions ◽

Alkyl Radicals ◽

Aryl Radicals ◽

Cross Coupling Reactions ◽

Oxidative Reactions ◽

Radical Cascade ◽

Cascade Processes ◽

A Chain ◽

Boronic Acid Derivatives

AbstractRadicals can be generated by the cleavage of the C—B bond of alkylboranes or boronic acid derivatives. The fragmentation process may result from a nucleohomolytic substitution process or from a redox process. The nucleohomolytic substitution is ideal for the generation of alkyl radicals and is usually part of a chain-reaction process. Redox processes (mainly oxidative reactions) have been used to generate both alkyl and aryl radicals. The use of stoichiometric oxidizing agents can be avoided by employing photoredox catalysis. A broad range of synthetic applications such as radical cascade processes, multicomponent reactions, and cross-coupling reactions in the presence of suitable metal catalysts are now possible. In their diversity, organoboron compounds represent one of the most general sources of radicals. The merging of radical chemistry with the classical chemistry of organoboron derivatives opens tremendous opportunities for applications in organic synthesis.

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