Preparation of multifunctional PEG-graft-Halloysite Nanotubes for Controlled Drug Release, Tumor Cell Targeting, and Bio-imaging

2018 ◽  
Vol 170 ◽  
pp. 322-329 ◽  
Author(s):  
Ait Mehdi Yamina ◽  
Meriem Fizir ◽  
Asma Itatahine ◽  
Hua He ◽  
Pierre Dramou
Keyword(s):  
Drug Release ◽  
Tumor Cell ◽  
Controlled Drug Release ◽  
Halloysite Nanotubes ◽  
Cell Targeting ◽  
Bio Imaging

PEG/RGD-modified magnetic polymeric liposomes for controlled drug release and tumor cell targeting

2012 ◽  
Vol 426 (1-2) ◽  
pp. 170-181 ◽  
Author(s):  
Wenya Su ◽  
Hanjie Wang ◽  
Sheng Wang ◽  
Zhenyu Liao ◽  
Shiyin Kang ◽  
...  
Keyword(s):  
Drug Release ◽  
Tumor Cell ◽  
Controlled Drug Release ◽  
Cell Targeting ◽  
Polymeric Liposomes

Quantum dots based vehicles for controlled drug release in conjunction with bio-imaging

2022 ◽  
pp. 197-236
Author(s):  
Aliesha Moudgil ◽  
Rajnigandha A. Shende ◽  
Anil T. Pawar ◽  
Kavita R. Gajbhiye ◽  
Virendra Gajbhiye ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Bio Imaging

scholarly journals Dual Surface-Functionalized Janus Nanocomposites of Polystyrene/Fe3O4@SiO2for Simultaneous Tumor Cell Targeting and Stimulus-Induced Drug Release

2013 ◽  
Vol 25 (25) ◽  
pp. 3485-3489 ◽  
Author(s):  
Feng Wang ◽  
Giovanni M. Pauletti ◽  
Juntao Wang ◽  
Jiaming Zhang ◽  
Rodney C. Ewing ◽  
...  
Keyword(s):  
Drug Release ◽  
Tumor Cell ◽  
Cell Targeting

scholarly journals Core/Shell Gel Beads with Embedded Halloysite Nanotubes for Controlled Drug Release

Coatings ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 70 ◽  
Author(s):  
Lorenzo Lisuzzo ◽  
Giuseppe Cavallaro ◽  
Filippo Parisi ◽  
Stefana Milioto ◽  
Rawil Fakhrullin ◽  
...  
Keyword(s):  
Drug Release ◽  
Coating Layer ◽  
Controlled Drug Release ◽  
Halloysite Nanotubes ◽  
Release Profile ◽  
Core Shell ◽  
Gel Beads ◽  
Relevant Effect ◽  
Hollow Cavity ◽  
Model Drug

The use of nanocomposites based on biopolymers and nanoparticles for controlled drug release is an attractive notion. We used halloysite nanotubes that were promising candidates for the loading and release of active molecules due to their hollow cavity. Gel beads based on chitosan with uniformly dispersed halloysite nanotubes were obtained by a dropping method. Alginate was used to generate a coating layer over the hybrid gel beads. This proposed procedure succeeded in controlling the morphology at the mesoscale and it had a relevant effect on the release profile of the model drug from the nanotube cavity.

Reducing the Risk in Controlled Drug Release by Using Tannic Acid in Liposomal Formulations

2018 ◽  
Vol 68 (12) ◽  
pp. 2925-2918
Author(s):  
Gabriela Cioca ◽  
Maricel Agop ◽  
Marcel Popa ◽  
Simona Bungau ◽  
Irina Butuc
Keyword(s):  
Drug Release ◽  
Tannic Acid ◽  
Release Rate ◽  
Controlled Drug Release ◽  
Toxicity Threshold ◽  
Release System ◽  
Liposomal Formulations ◽  
Cross Linker ◽  
Natural Cross

One of the main challenges in designing a release system is the possibility to control the release rate in order to maintain it at a constant value below a defined limit, to avoid exceeding the toxicity threshold. We propose a method of overcoming this difficulty by introducing the drug into liposomes, prior to its inclusion in the hydrogel. Furthermore, a natural cross linker (as is tannic acid) is used, instead of the toxic cross linkers commonly used, thus reducing the toxicity of the release system as a whole.

Nanostructured Ketorolac-Tromethamine/MCF: Synthesis, Characterization and Application in Drug Release System

2018 ◽  
Vol 14 (5) ◽  
pp. 432-439 ◽  
Author(s):  
Juliana M. Juarez ◽  
Jorgelina Cussa ◽  
Marcos B. Gomez Costa ◽  
Oscar A. Anunziata
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
The Body ◽  
Fickian Diffusion ◽  
Ketorolac Tromethamine

Background: Controlled drug delivery systems can maintain the concentration of drugs in the exact sites of the body within the optimum range and below the toxicity threshold, improving therapeutic efficacy and reducing toxicity. Mesostructured Cellular Foam (MCF) material is a new promising host for drug delivery systems due to high biocompatibility, in vivo biodegradability and low toxicity. Methods: Ketorolac-Tromethamine/MCF composite was synthesized. The material synthesis and loading of ketorolac-tromethamine into MCF pores were successful as shown by XRD, FTIR, TGA, TEM and textural analyses. Results: We obtained promising results for controlled drug release using the novel MCF material. The application of these materials in KETO release is innovative, achieving an initial high release rate and then maintaining a constant rate at high times. This allows keeping drug concentration within the range of therapeutic efficacy, being highly applicable for the treatment of diseases that need a rapid response. The release of KETO/MCF was compared with other containers of KETO (KETO/SBA-15) and commercial tablets. Conclusion: The best model to fit experimental data was Ritger-Peppas equation. Other models used in this work could not properly explain the controlled drug release of this material. The predominant release of KETO from MCF was non-Fickian diffusion.

Sign in / Sign up

Export Citation Format

Share Document