Toxicity assessment of palladium oxide nanoparticles derived from metallosurfactants using multi assay techniques in Allium sativum

2020 ◽  
Vol 187 ◽  
pp. 110752 ◽  
Author(s):  
Varsha Dogra ◽  
Gurpreet Kaur ◽  
Rajeev Kumar ◽  
Sandeep Kumar
Keyword(s):  
Allium Sativum ◽  
Toxicity Assessment ◽  
Palladium Oxide ◽  
Oxide Nanoparticles

Hepatotoxicity and chromosomal abnormalities evaluation due to single and repeated oral exposures of chromium oxide nanoparticles in Wistar rats

2019 ◽  
Vol 35 (8) ◽  
pp. 548-557 ◽  
Author(s):  
Ravish Fatima ◽  
Riaz Ahmad
Keyword(s):  
Chromium Oxide ◽  
Wistar Rats ◽  
Chromosomal Abnormalities ◽  
Metal Oxide Nanoparticles ◽  
Toxicity Assessment ◽  
Industrial Applications ◽  
Oxide Nanoparticles ◽  
Safety Issues ◽  
Sperm Abnormalities ◽  
Transmission Electron

Metal oxide nanoparticles (NPs) have widespread uses ranging from nanoelectronics to nanotherapeutics. Because of their expanding industrial applications, a better understanding of their toxicity is needed. So far, limited reports are available on chromium oxide NPs (Cr2O3 NPs) toxicity. In this work, Cr2O3 NPs were synthesized and characterized in a sequential manner using X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, and transmission electron microscopy. Dose- and time-dependent toxicity assessment of Cr2O3 NPs was carried out in Wistar rats by examining liver function biomarkers, tissue histopathology, micronuclei (MN) formation, and chromosomal aberrations (CAs) in bone marrow along with sperm abnormalities. The results of this study demonstrated typical XRD and FTIR patterns of Cr2O3 NPs with a size of approximately 23.47 nm. Animals exposed to Cr2O3 NPs, exhibited a significant increase in aspartate transaminase, alanine transaminase, alkaline phosphatase, gamma glutamyltransferase, and total bilirubin, signifying liver injury. Histopathology data also supported the marked alterations in the liver biochemistry of NPs-exposed animals. Further, an increase in the frequency of MN, CA, and sperm abnormalities suggested Cr2O3 NPs-mediated genotoxicity. It is, therefore, suggested that possible safety issues of Cr2O3 NPs should be addressed promptly with limited future use in occupational settings.

scholarly journals In vitro toxicity assessment of chitosan oligosaccharide coated iron oxide nanoparticles

2015 ◽  
Vol 2 ◽  
pp. 27-39 ◽  
Author(s):  
Sudeep Shukla ◽  
Alka Jadaun ◽  
Vikas Arora ◽  
Raj Kumar Sinha ◽  
Neha Biyani ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Toxicity Assessment ◽  
In Vitro Toxicity ◽  
Oxide Nanoparticles ◽  
Chitosan Oligosaccharide ◽  
In Vitro Toxicity Assessment

Toxicity Assessment of Cerium Oxide Nanoparticles in Cilantro (Coriandrum sativum L.) Plants Grown in Organic Soil

2013 ◽  
Vol 61 (26) ◽  
pp. 6224-6230 ◽  
Author(s):  
Maria Isabel Morales ◽  
Cyren M. Rico ◽  
Jose Angel Hernandez-Viezcas ◽  
Jose E. Nunez ◽  
Ana Cecilia Barrios ◽  
...  
Keyword(s):  
Cerium Oxide ◽  
Organic Soil ◽  
Toxicity Assessment ◽  
Coriandrum Sativum ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles

On the peculiar recycling properties of charcoal-supported palladium oxide nanoparticles in Sonogashira reactions

2014 ◽  
Vol 482 ◽  
pp. 157-162 ◽  
Author(s):  
Cybille Rossy ◽  
Jérôme Majimel ◽  
Mona Tréguer Delapierre ◽  
Eric Fouquet ◽  
François-Xavier Felpin
Keyword(s):  
Palladium Oxide ◽  
Oxide Nanoparticles ◽  
Supported Palladium ◽  
Sonogashira Reactions

scholarly journals Toxicity Assessment of Titanium (IV) Oxide Nanoparticles Using <i>Daphnia magna</i> (Water Flea)

2011 ◽  
Vol 26 ◽  
pp. e2011002 ◽  
Author(s):  
Seung Hyuck Bang ◽  
Thai-Hoang Le ◽  
Sung Kyu Lee ◽  
Pil Kim ◽  
Jong Soo Kim ◽  
...  
Keyword(s):  
Daphnia Magna ◽  
Toxicity Assessment ◽  
Oxide Nanoparticles ◽  
Water Flea

scholarly journals Palladium Oxide Nanoparticles: Preparation, Characterization and Catalytic Activity Evaluation

Coatings ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 207 ◽  
Author(s):  
Maurizio Muniz-Miranda ◽  
Angela Zoppi ◽  
Francesco Muniz-Miranda ◽  
Nicola Calisi
Keyword(s):  
Catalytic Activity ◽  
Simple Procedure ◽  
Aqueous Suspension ◽  
Palladium Oxide ◽  
Colloidal Nanoparticles ◽  
Oxide Nanoparticles ◽  
Visible Absorption ◽  
Palladium Nitrate ◽  
Tem Microscopy ◽  
Uv Visible

Stable palladium oxide nanoparticles were prepared in aqueous suspension with a very simple procedure, by dissolving palladium nitrate in water at a concentration around 10−4 M. UV-visible absorption spectroscopy was adopted to follow the formation of these nanoparticles, which were characterized by TEM microscopy, along with XRD, XPS and Raman measurements. DFT calculations allowed to interpret the Raman data and to clarify the species present at the surface of the nanoparticles. The catalytic activity of the latter was evaluated by monitoring the reduction of p-nitrophenol to p-aminophenol. This investigation paves the way to the use of these colloidal nanoparticles in processes of heterogeneous catalysis, in particular those concerning the catalytic degradation of aromatic derivatives that represent a serious danger for the environment as pollutants, as in the case of p-nitrophenol.

scholarly journals Jasada bhasma, a Zinc-Based Ayurvedic Preparation: Contemporary Evidence of Antidiabetic Activity Inspires Development of a Nanomedicine

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Rinku D. Umrani ◽  
Kishore M. Paknikar
Keyword(s):  
Zinc Oxide Nanoparticles ◽  
Scientific Evidence ◽  
Physicochemical Characterization ◽  
Modern Medicine ◽  
Toxicity Assessment ◽  
Antidiabetic Activity ◽  
Oxide Nanoparticles ◽  
New Drug ◽  
Normal Metabolism

The roles of metals in human physiology are well established. It is also known that many metals are required in trace amounts for normal metabolism and their deficiency leads to diseases. In Ayurveda, metal-based preparations, that is,bhasmas, are indicated for the treatment of several diseases. Standard textbooks of Ayurveda recommendJasada bhasma(zinc basedbhasma) as the treatment of choice for diabetes. Modern medicine also recognizes the important role of zinc in glucose homeostasis. Yet, studies that validate the use ofJasada bhasmaare few and uncomprehensive. There is an imminent need for a systematic study on physicochemical characterization, pharmacological efficacy, and toxicity assessment of severalbhasmapreparations to generate scientific evidence of their utility and safety. Interestingly, recent studies suggest thatbhasmascomprise submicronic particles or nanoparticles. Thus abhasma-inspired new drug discovery approach could emerge in which several metal based nanomedicines could be developed. This would help in utilizing the age old, time-tested wisdom of Ayurveda in modern medicine. One such study on antidiabetic activity ofJasada bhasmaand the corresponding new drug, namely, zinc oxide nanoparticles, is briefly discussed, as an example.

Sign in / Sign up

Export Citation Format

Share Document