Impact of body mass index on suppression of follicular development and ovulation using a transdermal patch containing 0.55-mg ethinyl estradiol/2.1-mg gestodene: a multicenter, open-label, uncontrolled study over three treatment cycles

Contraception ◽  
2014 ◽  
Vol 90 (3) ◽  
pp. 272-279 ◽  
Author(s):  
Carolyn L. Westhoff ◽  
Isabel Reinecke ◽  
Keith Bangerter ◽  
Martin Merz
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Ethinyl Estradiol ◽  
Follicular Development ◽  
Transdermal Patch ◽  
Open Label ◽  
Uncontrolled Study

scholarly journals TO COMPARE THE EFFECT OF CHITOSAN, LIFESTYLE MODIFICATION, AND COMBINATION OF CHITOSAN AND LIFESTYLE MODIFICATION ON BODY MASS INDEX IN OBESE PATIENTS

2019 ◽  
pp. 230-233
Author(s):  
VASUNDHARA BHOPLE ◽  
DEEPAK BHOSLE
Keyword(s):  
Body Mass Index ◽  
Comparative Study ◽  
Body Mass ◽  
Lifestyle Modification ◽  
T Test ◽  
Pronounced Effect ◽  
Obese Patients ◽  
Open Label ◽  
Study Population ◽  
Pronounced Reduction

Objective: The objective of this study was to compare the effect of chitosan, lifestyle modification, and combination of chitosan and lifestyle modification on body mass index (BMI) in obese patients. Methods: A prospective, randomized, open-label comparative study conducted for the period of 24 weeks. The study population was enrolled in three groups (chitosan 500 mg BD, lifestyle modification, and chitosan 500 mg BD and lifestyle modification). Data were analyzed using “t”-test and ANOVA. Results: There is a reduction in BMI in all the three groups. However, when we combined chitosan and lifestyle modification, there is pronounced reduction in BMI, which is statistically significant (p<0.0001). Conclusions: Chitosan and lifestyle modification have more pronounced effect on reduction on BMI as compared to monotherapy alone.

scholarly journals A randomized placebo controlled trial of metformin alone and metformin plus fixed dose combination of cyproterone acetate and ethinyl estradiol in hirsute women with polycystic ovarian syndrome

2018 ◽  
Vol 7 (5) ◽  
pp. 1011
Author(s):  
Shivani Jalota ◽  
Jatinder Singh ◽  
Ravi Saini
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Cyproterone Acetate ◽  
Polycystic Ovarian Syndrome ◽  
Ethinyl Estradiol ◽  
Chief Complaint ◽  
Fixed Dose ◽  
Beneficial Effects ◽  
Dose Combination ◽  
Ovarian Syndrome

Background: Polycystic ovarian syndrome is a common endocrine disorder seen in reproductive age group. Hirsutism, oligomennorhea and infertility being the most common chief complaint. Oral contraceptives have shown their efficacy in hirsute females. Metformin, an insulin sensitizer, have also shown some beneficial effects in improving metabolic abnormalities. Aim of this study is to compare the efficacy of metformin alone and metformin with fixed dose combination of cyproterone acetate and ethinyl estradiol in hirsute women with PCOS.Methods: 60 females of PCOS with chief complaint of hirsutism were enrolled. Patients were randomized to either metformin and Diane -35 (35 microgram ethinyl estradiol plus 2mg cyproterone acetate) or metformin and placebo for 9 months. Ferriman Gallwey score and body mass index was calculated at baseline, 3months, 6months and 9 months. FSH/LH/Prolactin/Testosterone/Fasting glucose and Fasting insulin levels were measured at the baseline and at the end of treatment.Results: Majority of females enrolled in the study were in third decade of life. Metformin and Diane- 35 showed higher reduction in Ferriman Gallwey score but Body mass index was reduced in both the groups. There was no significant difference seen between the groups with respect to biochemical profile.Conclusions: This data show that a combination of metformin and contraceptive pill may be more effective in treating hirsutism than metformin alone. Beneficial effects of therapy were seen in relation to BMI as well. Hence, combination therapy is better therapeutic option for treating hirsutism in PCOS. 

Changes in body weight and body mass index among psychiatric patients receiving lithium, valproate, or topiramate: An open-label, nonrandomized chart review

2002 ◽  
Vol 24 (10) ◽  
pp. 1576-1584 ◽  
Author(s):  
K.N.Roy Chengappa ◽  
L. Chalasani ◽  
Jaspreet S. Brar ◽  
H. Parepally ◽  
Patricia Houck ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Body Mass ◽  
Chart Review ◽  
Psychiatric Patients ◽  
Open Label

scholarly journals Pengaruh Jamu Obesitas terhadap Indeks Massa Tubuh, Lingkar Perut, dan Lingkar Lengan dibandingkan dengan Orlistat dan Evaluasi Keamanannya

2018 ◽  
Vol 46 (3) ◽  
pp. 177-182
Author(s):  
Danang Ardiyanto
Keyword(s):  
Clinical Trial ◽  
Body Mass Index ◽  
Randomized Clinical Trial ◽  
Body Mass ◽  
Open Label ◽  
Upper Arm ◽  
Safe Alternative ◽  
Arm Circumference ◽  
Sonchus Arvensis ◽  
Mid Upper Arm Circumference

Obesity could be a risk factor for other diseases, especially degenerative diseases. The prevalence of obesity is beginning to elevate at developing countries. Indonesia has some traditional ingredients that can be used for alternatives in obesity problems. But there isnot valid evidence for the efficacy and safety of traditional herbs. This study was conducted to evaluate efficacy of Jamu formulation in comparison with orlistat and evaluate its safety. Jamu formula contains Guazuma ulmifolia dried leaves, Murraya paniculata dried leaves, Rheum officinale dried roots, and Sonchus arvensis dried leaves. The present study was an randomized clinical trial open label undertaken in 242 subjects of obesity for 56 days. The Jamu group received a glass twice daily and orlistat group received a capsule twice daily. Efficacy was assessed by the changes in body mass index, waist and mid-upper arm circumference. Safety was evaluated by SGOT, SGPT, ureum, dan creatinine. There was a significant decrease (p<0,05) in body mass index, waist and mid-upper arm circumference after intervention in both group. Changes of those parameters were not significantly different (p>0,05) between both groups. No significant alteration was seen in most of the SGOT, SGPT, ureum, dan creatinine in Jamu formula groups. This study showed Jamu formula was an equally effective, but safe alternative for obesity management.   Abstrak   Obesitas dapat menjadi faktor resiko penyakit lain khususnya penyakit degeneratif. Prevalensi obesitas mulai mengalamai peningkatan di negara berkembang. Indonesia memiliki beberapa ramuan tradisional yang dapat digunakan untuk alternatif dalam masalah obesitas. Namun belum ada bukti yang kuat mengenai khasiat dan keamanan dari ramuan tradisional yang ada. Tujuan penelitian ini untuk mengetahui manfaat dan keamanan ramuan jamu yang terdiri dari simplisia daun jati belanda, daun kemuning, akar kelembak, dan daun tempuyung dibandingkan orlistat. Penelitian ini menggunakan randomized clinical trial (RCT) open label dengan 242 subyek selama 56 hari.. Kelompok jamu diberikan segelas jamu 2 kali sehari, sedangkan kelompok orlistat diberikan satu kapsul sehari dua kali. Parameter yang digunakan untuk mengevaluasi khasiat formula jamu dan orlistat adalah indeks masa tubuh (IMT), lingkar perut (LP), lingkar lengan atas (LLA). Sedangkan penilaian keamanan digunakan parameter SGOT, SGPT, BUN, dan kreatinin. Pemberian jamu dan orlistat dapat menurunkan IMT, LP, LLA secara bermakna (p<0,05) jika dibandingkan dengan hari ke-0. Penurunan IMT, LP, LLA kelompok jamu dibandingkan orlistat dapat dikatakan setara (p>0,05). Kelompok jamu menujukkan nilai SGOT, SGPT, ureum, dan kreatinin dalam rentang normal. Penelitian ini menunjukkan bahwa ramuan jamu obesitas secara klinis, khasiatnya sebanding dengan orlistat dan aman setelah intervensi selama 56 hari.

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