Chemotherapy for advanced non-pancreatic well-differentiated neuroendocrine tumours of the gastrointestinal tract, a systematic review and meta-analysis: A lost cause?

A systematic review and meta analysis has been undertaken in order to evaluate the effectiveness of adjuvant therapy following surgery for early ovarian cancer. Trials reported since 1990 have been of a higher quality enabling a meta analysis of adjuvant chemotherapy vs adjuvant radiotherapy and a meta analysis of adjuvant chemotherapy vs observation. There was no significant difference between radiotherapy and chemotherapy, though these comprised studies which demonstrated considerable heterogeneity. Chemotherapy did confer significant benefit over observation in terms of both overall and disease free survival. Except for women in whom adequate surgical staging has revealed well differentiated disease confined to one or both ovaries with intact capsule, platinum chemotherapy should be offered to reduce risk of recurrence.

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Systematic review with meta-analysis: The prevalence, risk factors and outcomes of upper gastrointestinal tract crohn's disease

Digestive and Liver Disease ◽

10.1016/j.dld.2021.07.037 ◽

2021 ◽

Author(s):

Yip Han Chin ◽

Cheng Han Ng ◽

Snow Yunni Lin ◽

Sneha Rajiv Jain ◽

Gwyneth Kong ◽

...

Keyword(s):

Risk Factors ◽

Systematic Review ◽

Crohn’S Disease ◽

Gastrointestinal Tract ◽

Crohn's Disease ◽

Meta Analysis ◽

Upper Gastrointestinal Tract ◽

Upper Gastrointestinal

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Dynamic Changes of Mitochondrial DNA Copy Number in Gastrointestinal Tract Cancers: A Systematic Review and Meta-analysis

Cancer Investigation ◽

10.1080/07357907.2020.1857394 ◽

2020 ◽

pp. 1-35

Author(s):

Mehdi Alikhani ◽

Eliette Touati ◽

Morteza Karimipoor ◽

Massoud Vosough ◽

Sana Eybpoosh ◽

...

Keyword(s):

Systematic Review ◽

Mitochondrial Dna ◽

Gastrointestinal Tract ◽

Copy Number ◽

Meta Analysis ◽

Dna Copy Number ◽

Dynamic Changes ◽

Mitochondrial Dna Copy Number

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The effect of diets delivered into the gastrointestinal tract on gut motility after colorectal surgery—a systematic review and meta-analysis of randomised controlled trials

European Journal of Clinical Nutrition ◽

10.1038/s41430-019-0474-1 ◽

2019 ◽

Vol 73 (10) ◽

pp. 1331-1342 ◽

Cited By ~ 1

Author(s):

Sophie Hogan ◽

Daniel Steffens ◽

Anna Rangan ◽

Michael Solomon ◽

Sharon Carey

Keyword(s):

Systematic Review ◽

Gastrointestinal Tract ◽

Colorectal Surgery ◽

Randomised Controlled Trials ◽

Meta Analysis ◽

Controlled Trials ◽

Gut Motility ◽

Randomised Controlled

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Classification and pathology of gastroenteropancreatic neuroendocrine neoplasms

Endocrine Related Cancer ◽

10.1530/erc-11-0013 ◽

2011 ◽

Vol 18 (S1) ◽

pp. S1-S16 ◽

Cited By ~ 180

Author(s):

Günter Klöppel

Keyword(s):

Gastrointestinal Tract ◽

Neuroendocrine Tumours ◽

Neuroendocrine Tumour ◽

Tnm Stage ◽

Neuroendocrine Neoplasms ◽

Gastroenteropancreatic Neuroendocrine Neoplasms ◽

Poorly Differentiated ◽

Well Differentiated ◽

Neuroendocrine Carcinomas

Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are composed of cells with a neuroendocrine phenotype. The old and the new WHO classifications distinguish between well-differentiated and poorly differentiated neoplasms. All well-differentiated neoplasms, regardless of whether they behave benignly or develop metastases, will be called neuroendocrine tumours (NETs), and graded G1 (Ki67 <2%) or G2 (Ki67 2–20%). All poorly differentiated neoplasms will be termed neuroendocrine carcinomas (NECs) and graded G3 (Ki67 >20%). To stratify the GEP-NETs and GEP-NECs regarding their prognosis, they are now further classified according to TNM-stage systems that were recently proposed by the European Neuroendocrine Tumour Society (ENETS) and the AJCC/UICC. In the light of these criteria the pathology and biology of the various NETs and NECs of the gastrointestinal tract (including the oesophagus) and the pancreas are reviewed.

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