Diminished circulating plasma and elevated lymph node culture supernatant levels of IL-10 family cytokines in tuberculous lymphadenitis

Lymph node involvement is the commonest form of extra pulmonary tuberculosis (EPTB). This study was undertaken to evaluate the role of PCR using IS6110 as a target for Mycobacterium tuberculosis complex in the diagnosis of tuberculous lymphadenitis (TB-L) and was done in Microbiology department of Sir Salimullah Medical College from July 2009 to June 2010. Fine needle aspiration was performed on 107 patients with a clinical suspicion of tuberculous lymphadenitis from different hospitals of Dhaka City Corporation area. All the aspirated samples were subjected to culture and PCR for M.tuberculosis. Out of 107 patients with lymphadenopathy most of the patients (85.9%) had cervical lymph node enlargement followed by axillary groups (12.1%) and inguinal groups (1.9%). Out of 107 cases, 65 (60.7%) were PCR positive and 56 (52.3%) were culture positive. Among 51 (47.7%) culture negative cases 9 (17.65) were PCR positive. Sensitivity of PCR was 100% and specificity was 82.4%.The positive predictive value (PPV), negative predictive value (NPV) and accuracy of PCR were 86.2%, 100% and 91.6% respectively. PCR is the most sensitive in the detection of M.tuberculosis in fine needle aspirate and could be useful technique in establishing the diagnosis of tuberculous lymphadenitis.

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Caseating Tuberculous Lymphadenitis- A Case Report

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i41b32342 ◽

2021 ◽

pp. 37-40

Author(s):

Mayur B. Wanjari ◽

Deeplata Mendhe ◽

Pratibha Wankhede ◽

Sagar Alwadkar

Keyword(s):

Case Report ◽

Lymph Node ◽

Granulomatous Inflammation ◽

Neck Region ◽

Needle Aspiration ◽

Tuberculous Lymphadenitis ◽

Submandibular Region ◽

Hiv Test ◽

Painful Sensation ◽

Loss Of Appetite

Introduction: Tuberculosis lymphadenitis (or tuberculous adenitis) is the most common type of infection with tuberculosis that occurs outside of the respiratory system. Tuberculosis lymphadenitis is a chronic condition caused by Mycobacterium tuberculosis in the granulomatous inflammation of the lymph node caused by caseated necrosis. The number of people who contact tuberculosis is estimated at 8 million per year, and about 3 million people die from tuberculosis in the world. Presentation of Case: In this case report we delineate the case of a female patient, 26-year-old, she had some pain and lymph node swelling in her right submandibular region since from 4 months and was diagnosed as right Caseating Tuberculous Lymphadenitis, associated with the cervical (neck) region, who was immunocompetent and HIV test negative, with a history of recurring fever, weight loss, loss of appetite for the last 4 months. On physical examination, she had swelling approximately 3×3 cm in the right submandibular region and a hard mass and painful sensation were noticed in her right submandibular region. On Fine needle aspiration cytology of submandibular lymph node reveals Caseating Tuberculous Lymphadenitis. this is extremely rare in immunocompetent individuals.

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Case report: association between lymph node tuberculosis and breast cancer

Mastology ◽

10.29289/259453942020v30s1031 ◽

2020 ◽

Vol 30 (Suppl 1) ◽

Author(s):

Marina Fontes Medeiros ◽

Gustavo Lanza de Melo ◽

Thássia Mariz de Melo ◽

Rachel Saraiva Teatini Selim de Sales ◽

Janaina Cotta Rodrigues Ferreira

Keyword(s):

Breast Cancer ◽

Case Report ◽

Lymph Node ◽

Pulmonary Nodules ◽

Southeastern Brazil ◽

Tuberculous Lymphadenitis ◽

Axillary Lymph ◽

Safety Margins ◽

Lymph Node Tuberculosis ◽

The Right

Introduction: Lymph node tuberculosis is the most common extra-lung presentation of tuberculosis, responsible for 43% of peripheral lymphadenopathies in developing countries. The coexistence between lymph node tuberculosis and breast cancer is rare, ranging from 0.1% to 4.9%.Objective: To present a case of axillary lymph node tuberculosis due to its rare association with breast cancer. Methods: We have investigated the case of a 48-year-old woman from Congonhas, Minas Gerais, Southeastern Brazil, who presented a palpable nodule in the junction of the right upper quadrants with two years of progression, category 4B of the Breast Imaging Reporting and Data System (BI-RADS) on mammography and ultrasound, with core needle biopsy compatible with benignancy. No axillary lymphadenopathy was identified. Case report: The patient underwent resection of the right breast nodule with safety margins due to disagreement between biopsy and imaging tests. Anatomopathological examination was consistent with luminal B invasive ductal carcinoma, measuring 1.6 cm. The patient was submitted to sentinel lymph node biopsy using patent blue in the right axilla. Anatomopathological analysis revealed tuberculous lymphadenitis. Chest computed tomography showed pulmonary nodules. The patient received adjuvant radiotherapy and tamoxifen, as well as antituberculous antibiotics, with regression of pulmonary nodules. The final staging was pT1cN0M0- IA. Discussion: Most cases of coexistence between these diseases involve tuberculous lymphadenitis with or without neoplastic lymph node involvement. Some reports indicate that the involvement by tuberculosis does not prevent neoplastic proliferation. Before starting chemotherapy, tuberculosis must be treated to avoid the immunosuppressive effect that can cause a spread of tuberculosis. Conclusion: Despite the rare coexistence of these diseases, we should not rule out this possibility, especially in endemic tuberculosis areas. Also, an accurate diagnosis prevents incorrect staging and can spare the patient from a more aggressive treatment.

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Diagnosis of lymph node tuberculosis using the GeneXpert MTB/RIF in Bangladesh

Mediscope ◽

10.3329/mediscope.v6i1.38939 ◽

2018 ◽

Vol 6 (1) ◽

pp. 19-23

Author(s):

TE Nur ◽

AU Hosna ◽

N Rayhan ◽

N Nazneen

Keyword(s):

Lymph Node ◽

Sensitivity And Specificity ◽

Conventional Method ◽

Rapid Diagnosis ◽

Tuberculous Lymphadenitis ◽

Culture Test ◽

Lymph Node Tuberculosis ◽

Medical University

The purpose of this study was to evaluate the accuracy of the GeneXpert M. tuberculosis (MTB)/ rifampicin (RIF) test for the detection of MTB in lymph node aspirated samples. This study was conducted in the Department of Pathology, Bangabandhu Sheikh Mujib Medical University, Bangladesh. This study was done during the period from July 2013 to May 2015. A total of 317 clinically suspected tuberculous lymphadenitis patients without malignancy were included in the study. The culture test and GeneXpert test were used for detection of MTB in lymph node aspirated material. Among the 317 samples tested, the GeneXpert detected the DNA of MTB in 167 samples (52.7%), whereas culture test was positive in 74 (23.3%) specimens. GeneXpert also detected 8 RIF resistance cases. GeneXpert sensitivity and specificity results were assessed according to culture results. The sensitivity and specificity of the GeneXpert assay was 95.9% and 60.5%, respectively. The implementation of the GeneXpert MTB/RIF assay may dramatically improve the rapid diagnosis of lymph node TB. The GeneXpert MTB/RIF may replace usual conventional method like culture test for detection of MTB. Mediscope Vol. 6, No. 1: Jan 2019, Page 19-23

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Tuberculous Lymphadenitis Mimicking Nodal Metastasis in Follicular Variant Papillary Thyroid Carcinoma

Case Reports in Medicine ◽

10.1155/2016/5623104 ◽

2016 ◽

Vol 2016 ◽

pp. 1-3 ◽

Cited By ~ 1

Author(s):

Marc Gregory Yu ◽

Jenny Maureen Atun

Keyword(s):

Lymph Node ◽

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Preoperative Evaluation ◽

Cervical Lymphadenopathy ◽

Developed Countries ◽

Nodal Metastasis ◽

Tuberculous Lymphadenitis ◽

Papillary Thyroid ◽

Follicular Variant

Tuberculous (TB) lymphadenitis can mimic cervical node metastasis from papillary thyroid carcinoma (PTC) since the distribution and appearance of affected lymph nodes are similar. We present the case of an asymptomatic 50-year-old Filipino who sought consult for a gradually enlarging anterior neck mass and a single palpable cervical lymph node. Preoperative workup suggested a thyroid malignancy with nodal metastasis. He underwent total thyroidectomy with node dissection where histopathology confirmed follicular variant- (FV-) PTC. Lymph node examination, however, revealed TB lymphadenitis, and the patient was given standard antimycobacterial therapy. This is the first documented case in Southeast Asia, a high TB burden region. This is also the first report involving FV-PTC, which has features between those of conventional PTC and follicular thyroid carcinoma. The case suggests that, in endemic areas, TB should be a differential in the etiology of cervical lymphadenopathy in PTC patients. In developed countries, this differential diagnosis is also valuable because of the increasing incidence of HIV and TB coinfection. Proper preoperative evaluation is important and needs to be highlighted in the formulation of local guidelines.

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Adenoma thyroid with supraclavicular tuberculous lymphadenitis Masquerading as malignancy thyroid with Metastasis - Diagnostic dilemma

PERSPECTIVES IN MEDICAL RESEARCH - 2 ◽

10.47799/pimr.0802.22 ◽

2020 ◽

Vol 8 (2) ◽

pp. 106-108

Author(s):

Nagendra Mahendra ◽

Abhijeet Ingle ◽

Dharmendra kumar borad ◽

Majed Abdul Basit Momin

Keyword(s):

Lymph Node ◽

Clinical Examination ◽

Follicular Adenoma ◽

Clinical Importance ◽

Follicular Carcinoma ◽

Needle Aspiration ◽

Tuberculous Lymphadenitis ◽

Supraclavicular Lymph Node ◽

Diagnostic Dilemma ◽

Thyroid Swelling

Thyroid swelling or goitre is one of the commonest presentations among female patients more than males attending ENT out patients. The clinical importance of thyroid swelling is related to evaluating their functional status and assess,whether it is benign,malignant ,hypo or hyper active.Even if benign should look for pressure symptoms which justifies surgery.Tuberculous lymphadenitis is the most common form of extrapulmonary tuberculosis.Coexistence of thyroid swelling with supraclavicular lymph node mimicking malignancy with metastatic deposit is unusual and always to be evaluated. We report a case of a 45-year female,who on outside initial evaluation was diagnosed as follicular carcinoma of thyroid. However clinical examination revealed a palpable supraclavicular lymph node. Thus subjected to a repeat FNA (fine needle aspiration) from thyroid which revealed benign thyroid follicular adenoma and FNA from supraclavicular lymph node revealed tuberculous lymphadenitis, which was further confirmed by histological sections post operatively. This case emphasizes the need for thorough clinical examination and utility of image guided FNA to rule out the biological nature of these lesions.

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A Case of Primary Breast Cancer where Preoperative Lymph Node Evaluation was Difficult Because Tuberculous Lymphadenitis Merged it with a Sentinel Lymph Node

Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) ◽

10.3919/jjsa.75.3245 ◽

2014 ◽

Vol 75 (12) ◽

pp. 3245-3248

Author(s):

Akiko OKADA ◽

Toru MURATA ◽

Masaya INOUE ◽

Yasushi TAKENOUCHI ◽

Takashi NAKAYAMA

Keyword(s):

Breast Cancer ◽

Lymph Node ◽

Sentinel Lymph Node ◽

Primary Breast Cancer ◽

Tuberculous Lymphadenitis ◽

Lymph Node Evaluation

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CLINICOPATHOLOGICAL STUDY OF CORRELATION BETWEEN FNAC SMEAR , ZN STAINED SMEAR & HIV STATUS IN CLINICALLY SUSPECTED CASES OF LYMPH NODE TUBERCULOSIS IN URBAN EASTERN INDIA

10.36106/paripex/8107895 ◽

2020 ◽

pp. 59-62

Author(s):

Susmita Nag ◽

Abantika Konar ◽

Sumitra Basuthakur

Keyword(s):

Lymph Node ◽

Hiv Infection ◽

Needle Aspiration ◽

Cross Sectional Study ◽

Tuberculous Lymphadenitis ◽

Pulmonary Medicine ◽

Hiv Status ◽

Cross Sectional ◽

Increased Risk ◽

Caseation Necrosis

BACKGROUND: Tuberculous lymphadenitis (TBL) is the commonest form of extra pulmonary tuberculosis. Fine Needle Aspiration Cytology (FNAC) is a simple outpatient diagnostic procedure used in the diagnosis of TBL and all stages of Human Immunodeficiency Virus (HIV) infection are associated with increased risk of tuberculosis (TB). AIM & OBJECTIVE: To correlate different cytomorphologies of FNAC smears and presence or absence of Acid fast bacilli (AFB) in the Ziehl Neelsen (ZN) stained smear prepared from the same aspirate. Association of HIV infection are also to be evaluated. METHOD: An observational cross-sectional study was conducted at department of pathology in collaboration with department of pulmonary medicine, Medical College & Hospital, Kolkata from January 2015 to June 2016.It included 305 cases with enlarged palpable lymph nodes. FNAC done; aspirated smears were stained with papanicolaou, Leishman-Giemsa and ZN stains. HIV status were also noted. RESULTS: 251 aspirates were reported on cytomorphology as suggestive of TBL with 117 (47.01 %) AFB positivity in ZN stained smears. Cervical lymph node were most commonly involved site (86.84 %) and females (63.75%) were affected more than males (36.25%).Most cases of AFB positive smears were associated with caseation necrosis only (71.8 %). 17 (6.77 %) out of 251 cases were co infected with HIV. CONCLUSION: Special stains should be done in all suspected cases of TB lymphadenitis and most common cytomorphology associated with AFB positivity is caseation necrosis without granuloma. Also it can be concluded that TB/HIV co infection is not predominant in India.

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