Serum trypsin inhibitory capacity in normal pregnancy and gestational diabetes mellitus

2009 ◽  
Vol 84 (3) ◽  
pp. 201-204 ◽  
Author(s):  
Minoo Yaghmaei ◽  
Mohammad Hashemi ◽  
Abdolsamad Shikhzadeh ◽  
Mojgan Mokhtari ◽  
Abbasali Niazi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Normal Pregnancy ◽  
Inhibitory Capacity ◽  
Serum Trypsin

Insulin secretion and insulin sensitivity in normal pregnancy and gestational diabetes mellitus

2003 ◽  
Vol 17 (2) ◽  
pp. 137-142 ◽  
Author(s):  
E. Akbay ◽  
M. B. Tıras ◽  
I. Yetkin ◽  
F. Törüner ◽  
R. Ersoy ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Secretion ◽  
Insulin Sensitivity ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Normal Pregnancy

scholarly journals Gestational diabetes mellitus causes dyslipidemia in late trimester: mini review

2019 ◽  
Vol 9 (1) ◽  
pp. 453
Author(s):  
Poonguzhalai S. ◽  
Kalyanikutty K. P.
Keyword(s):  
Diabetes Mellitus ◽  
Lipid Metabolism ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Gestational Age ◽  
Significant Risk ◽  
Normal Pregnancy ◽  
Adverse Outcomes ◽  
Peripheral Tissues ◽  
Management Protocol

The incidence of gestational diabetes mellitus (GDM) is increasing rapidly worldwide. Many women with gestational diabetes mellitus are likely to have type 2 diabetes. With the extensive management protocol for GDM we are able to obtain a good glycaemic control but still excess morbidity prevails among GDM pregnancy compared to normal pregnancy. This may be due to the dysfunction of lipid metabolism. Changes in carbohydrate and lipid metabolism occur during pregnancy to ensure a continuous supply of nutrients to the growing fetus despite intermittent maternal food intake. Exaggerated reduction in insulin sensitivity in the peripheral tissues combined with peripheral adipose tissue lipolysis in GDM pregnancy than normal pregnancy results in increased maternal lipoprotein concentrations and elevated lipoprotein triglyceride content. An altered lipid profile on the maternal side would modulate the quantity and quality of lipids being transferred to the fetus. Hypertriacylglycerolemia in gestational diabetes mellitus has been related to a significant risk of having neonates that are large for gestational age and it is considered as a major cause of preeclampsia in the late gestational age. So, the recent researchers emphasize on targeting lipid metabolism in pregnant women with GDM to avoid the adverse outcomes of pregnancy.

Serum adenosine deaminase activity in gestational diabetes mellitus and normal pregnancy

2009 ◽  
Vol 281 (4) ◽  
pp. 623-626 ◽  
Author(s):  
Mojgan Mokhtari ◽  
Mohammad Hashemi ◽  
Minoo Yaghmaei ◽  
Fariba Molashahi ◽  
Abdolsamad Shikhzadeh ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Adenosine Deaminase ◽  
Normal Pregnancy ◽  
Adenosine Deaminase Activity

Evaluation of the serum leptin in normal pregnancy and gestational diabetes mellitus in Zahedan, southeast Iran

2010 ◽  
Vol 284 (3) ◽  
pp. 539-542 ◽  
Author(s):  
Mojgan Mokhtari ◽  
Mohammad Hashemi ◽  
Minoo Yaghmaei ◽  
Mohammad Naderi ◽  
Abdolsamad Shikhzadeh ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Normal Pregnancy ◽  
Serum Leptin

scholarly journals Previous Gestational Diabetes Mellitus and Markers of Cardiovascular Risk

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Nikolaos Vrachnis ◽  
Areti Augoulea ◽  
Zoe Iliodromiti ◽  
Irene Lambrinoudaki ◽  
Stavros Sifakis ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Current Knowledge ◽  
Normal Pregnancy ◽  
Metabolic Abnormalities ◽  
Cvd Risk ◽  
Maternal Complications

The prevalence of gestational diabetes mellitus (GDM) in the developed world has increased at an alarming rate over the last few decades. GDM has been shown to be associated with postpartum diabetes, insulin resistance, hypertension, and dyslipidemia. A history of previous GDM (pGDM), associated or not with any of these metabolic abnormalities, can increase the risk of developing not only type 2 diabetes mellitus but also cardiovascular disease (CVD) independent of a diagnosis of type 2 diabetes later in life. In this paper we discuss the relationship among inflammatory markers, metabolic abnormalities, and vascular dysfunction in women with pGDM. We also review the current knowledge on metabolic modifications occurring in normal pregnancy and the link between alterations of a normal metabolic state with the long-term maternal complications that may result in increased CVD risk. Our review of studies on pGDM prompts us to recommend that these women be considered a population at risk for later CVD events, which however could be avoided via the use of specially designed follow-up programs in the future.

scholarly journals Identification of a novel association for the WWOX/HIF1A axis with gestational diabetes mellitus (GDM)

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e10604
Author(s):  
Izabela Baryla ◽  
Elzbieta Pluciennik ◽  
Katarzyna Kośla ◽  
Marzena Wojcik ◽  
Andrzej Zieleniak ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Glucose Metabolism ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Expression Profiles ◽  
Hypoxia Inducible Factor ◽  
Gene Expression Profiles ◽  
Normal Pregnancy ◽  
Normal Tissues ◽  
Genes Encoding

Background Although the WW-domain-containing oxidoreductase (WWOX)/Hypoxia-inducible factor 1 (HIF1) pathway is a well-known regulator of cellular glucose and energy metabolism in pathophysiological processes, its role in gestational diabetes mellitus (GDM), remains elusive. We undertook this study to determine the effect of WWOX/HIF1A signaling on the expression of glucose metabolism genes in GDM patients. Methods Leukocytes were obtained from 135 pregnant women with (n = 98) or without (n = 37) GDM and, in turn, 3 months (n = 8) and 1 year (n = 12) postpartum. Quantitative RT-PCR was performed to determine gene expression profiles of the WWOX/HIF1A-related genes, including those involved in glucose transport (SLC2A1, SLC2A4), glycolytic pathway (HK2, PKM2, PFK, LDHA), Wnt pathway (DVL2, CTNNB1), and inflammatory response (NFKB1). Results GDM patients displayed a significant downregulation of WWOX with simultaneous upregulation of HIF1A which resulted in approximately six times reduction in WWOX/HIF1A ratio. As a consequence, HIF1A induced genes (SLC2A1, HK2, PFK, PKM) were found to be overexpressed in GDM compared to normal pregnancy and negative correlate with WWOX/HIF1A ratio. The postpartum WWOX expression was higher than during GDM, but its level was comparable to that observed in normal pregnancy. Conclusions The obtained results suggest a significant contribution of the WWOX gene to glucose metabolism in patients with gestational diabetes. Decreased WWOX expression in GDM compared to normal pregnancy, and in particular reduction of WWOX/HIF1A ratio, indicate that WWOX modulates HIF1α activity in normal tissues as described in the tumor. The effect of HIF1α excessive activation is to increase the expression of genes encoding proteins directly involved in the glycolysis which may lead to pathological changes in glucose metabolism observed in gestational diabetes.

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