Elevated haemoglobin A1c but not fasting plasma glucose conveys risk of chronic kidney disease in non-diabetic individuals

2018 ◽  
Vol 146 ◽  
pp. 233-239 ◽  
Author(s):  
Tomomichi Koshi ◽  
Hiroyuki Sagesaka ◽  
Yuka Sato ◽  
Kazuko Hirabayashi ◽  
Hideo Koike ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Haemoglobin A1c ◽  
Fasting Plasma

scholarly journals The burden of diabetes and hyperglycemia in Brazil and its states: findings from the Global Burden of Disease Study 2015

2017 ◽  
Vol 20 (suppl 1) ◽  
pp. 90-101 ◽  
Author(s):  
Bruce Bartholow Duncan ◽  
Elisabeth Barboza França ◽  
Valéria Maria de Azeredo Passos ◽  
Ewerton Cousin ◽  
Lenice Harumi Ishitani ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Burden Of Disease ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Fasting Plasma ◽  
Life Years ◽  
High Fasting Plasma Glucose

ABSTRACT: Introduction and objective: The global burden of disease (GBD) 2015 project, extends GBD analyses to include Brazilian federative units separately. We take advantage of GBD methodological advances to describe the current burden of diabetes and hyperglycemia in Brazil. Methods: Using standard GBD 2015 methods, we analyzed the burden of diabetes, chronic kidney disease due to diabetes and high fasting plasma glucose in Brazil and its states. Results: The age-standardized rate of disability-adjusted life years (DALYs) which was lost to high fasting plasma glucose, a category which encompasses burdens of diabetes and of lesser hyperglycemia, were 2448.85 (95% UI 2165.96-2778.69) /100000 for males, and 1863.90 (95% UI 1648.18-2123.47) /100000 for females in 2015. This rate was more than twice as great in states with highest burden, these being overwhelmingly in the northeast and north, compared with those with lowest rates. The rate of crude DALYs for high fasting plasma glucose, increased by 35% since 1990, while DALYs due to all non-communicable diseases increased only by 12.7%, and DALYs from all causes declined by 20.5%. Discussion: The worldwide pandemic of diabetes and hyperglycemia now causes a major and growing disease burden in Brazil, especially in states with greater poverty and a lesser educational level. Conclusion: Diabetes and chronic kidney disease due to diabetes, as well as high fasting plasma glucose in general, currently constitute a major and growing public health problem in Brazil. Actions to date for their prevention and control have been slow considering the magnitude of this burden.

Prognostic value of haemoglobin A1c and fasting plasma glucose for incident diabetes and implications for screening

2011 ◽  
Vol 26 (10) ◽  
pp. 779-787 ◽  
Author(s):  
Ben Schöttker ◽  
Elke Raum ◽  
Dietrich Rothenbacher ◽  
Heiko Müller ◽  
Hermann Brenner
Keyword(s):  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Prognostic Value ◽  
Incident Diabetes ◽  
Haemoglobin A1c ◽  
Fasting Plasma

scholarly journals Comparative Abilities of Fasting Plasma Glucose and Haemoglobin A1c in Predicting Metabolic Syndrome among Apparently Healthy Normoglycemic Ghanaian Adults

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Nafiu Amidu ◽  
William Kwame Boakye Ansah Owiredu ◽  
Lawrence Quaye ◽  
Peter Paul Mwinsanga Dapare ◽  
Yussif Adams
Keyword(s):  
Metabolic Syndrome ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Cross Sectional Study ◽  
Haemoglobin A1c ◽  
Risk Markers ◽  
Cross Sectional ◽  
Fasting Plasma ◽  
Tamale Metropolis ◽  
Apparently Healthy

There are arguments as to whether haemoglobin A1c (HbA1c) better predicts Metabolic syndrome (MetS) than fasting plasma glucose. The aim of the study was to explore the comparative abilities of HbA1c and Fasting plasma glucose (FPG) in predicting cardiometabolic risk among apparently healthy adults in the Tamale metropolis. This study was a cross-sectional study conducted in the Tamale metropolis from September, 2017, to January, 2018, among one hundred and sixty (160) apparently healthy normoglycemic adults. A self-designed questionnaire was administered to gather sociodemographic data. Anthropometric and haemodynamic data were also taken and blood samples collected for haemoglobin A1c (HbA1c), fasting plasma glucose (FPG), and lipid profile. MetS was classified using the harmonised criteria as indicated in the joint interim statement (JIS). Out of the 160 participants, 42.5% were males and 57.5% were females. FPG associated better with MetS and other cardiovascular risk markers, compared to HbA1c. FPG had the largest area under curve for predicting MetS and its components. This study shows a stronger association between FPG and MetS compared with haemoglobin A1c; it also provides evidence of a superior ability of FPG over HbA1c in predicting MetS and other adverse cardiovascular outcomes in apparently heathy normoglycemic individuals.

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