Transjugular intrahepatic porto-systemic shunt is a risk factor for liver dysplasia but not hepatocellular carcinoma: A retrospective study of explanted livers

At the end of 2019, a new coronavirus (SARS-CoV-2) was discovered in China, causing the coronavirus infection COVID-19. The ongoing COVID-19 pandemic poses a major challenge to health systems around the world. There is still little information on how infection affects liver function and the significance of pre-existing liver disease as a risk factor for infection and severe COVID-19. In addition, some drugs used to treat the new coronavirus infection are hepatotoxic. In this article, we analyze data on the impact of COVID-19 on liver function, as well as on the course and outcome of COVID-19 in patients with liver disease, including hepatocellular carcinoma, or those on immunosuppressive therapy after liver transplantation.

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Faculty Opinions recommendation of Obesity is an independent risk factor for hepatocellular carcinoma development in chronic hepatitis C patients.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1112156.568142 ◽

2008 ◽

Author(s):

Dieter Juengst

Keyword(s):

Hepatocellular Carcinoma ◽

Chronic Hepatitis ◽

Risk Factor ◽

Hepatitis C ◽

Chronic Hepatitis C ◽

Independent Risk Factor ◽

Chronic Hepatitis C Patients

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Study of Toll-like Receptor 3 Gene Polymorphism as a Novel Risk Factor for HCV-related Hepatocellular Carcinoma in Egypt

Current Cancer Drug Targets ◽

10.2174/1568009620666200319102929 ◽

2020 ◽

Vol 20 (5) ◽

pp. 382-389 ◽

Cited By ~ 1

Author(s):

Shimaa EL-Sharawy ◽

Osama El- Sayed Negm ◽

Sherief Abd-Elsalam ◽

Hesham Ahmed EL-Sorogy ◽

Mona Ahmed Helmy Shehata

Keyword(s):

Hepatocellular Carcinoma ◽

Risk Factor ◽

Gene Polymorphism ◽

Clinical Laboratory ◽

Treatment Options ◽

Laboratory Evaluation ◽

Toll Like Receptor ◽

Focal Lesions ◽

Tlr3 Gene ◽

Cirrhotic Patients

Background & Aims: Hepatocellular carcinoma (HCC) is a highly aggressive cancer with few treatment options. Toll-like receptor 3 (TLR3) plays a key role in innate immunity and may affect the development of cancers. This study aimed to investigate the association between TLR3 gene polymorphism and HCV-related hepatocellular carcinoma in Egypt. Methods: This work was conducted on 70 individuals; fifty HCV cirrhotic patients were included in two groups; with HCC (30 patients) and without HCC (20 patients) compared with a group of 20 apparently healthy controls. All of the studied individuals underwent clinical-laboratory evaluation. TLR3 gene single-nucleotide polymorphism (SNP) (+1234C/T) was tested by polymerase chain reaction- restriction fragment length polymorphism. Results: This study reported that the prevalence of TLR3 +1234TT genotype was significantly increased in cirrhotic patients with HCC than without HCC, while it was not detected at all among the controls. When analyzing the TLR3 SNP +1234C/T with different clinical parameters in HCC patients, there was a significant association between+1234C/T SNP; namely TT genotype and each of the hepatic focal lesions᾽ number, size and the patients᾽ higher Okuda and BCLC stages. No association could be detected between TLR3 SNP and the age, sex, Child-Pugh grades, MELD score or AFP of the studied HCC cases. Conclusion: TLR3 gene SN P +1234C/T could be a novel risk factor for the HCV-related HCC among the Egyptian population.

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