scholarly journals Oesophageal squamous cell carcinoma in high-risk Chinese populations: Possible role for vascular epithelial growth factor A

2014 ◽  
Vol 50 (16) ◽  
pp. 2855-2865 ◽  
Author(s):  
Asieh Golozar ◽  
Terri H. Beaty ◽  
Patti E. Gravitt ◽  
Ingo Ruczinski ◽  
You-Lin Qiao ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Growth Factor ◽  
High Risk ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oesophageal Squamous Cell Carcinoma ◽  
Chinese Populations ◽  
Epithelial Growth Factor ◽  
Vascular Epithelial Growth Factor ◽  
Epithelial Growth

Amplification and expression of the TGF-α, EGF receptor and c-myc genes in four human oesophageal squamous cell carcinoma lines

1993 ◽  
Vol 13 (5) ◽  
pp. 303-312 ◽  
Author(s):  
Gregory J. Jones ◽  
Nina S. Heiss ◽  
Robin B. Veale ◽  
Alan L. Thornley
Keyword(s):  
Squamous Cell Carcinoma ◽  
Growth Factor ◽  
Cell Carcinoma ◽  
Cell Lines ◽  
Gene Amplification ◽  
Squamous Cell ◽  
Egf Receptor ◽  
Transforming Growth Factor ◽  
Scatchard Analysis ◽  
Oesophageal Squamous Cell Carcinoma

We have previously shown that four human oesophageal squamous cell carcinoma (SCC) cell lines secrete significant quantities of transforming growth factor alpha (TGF-α) in vitro. Three of these lines are known to produce supernumary low-affinity epidermal growth factor receptors (EGF-Rs). Using an125I-EGF compeitive binding assay and Scatchard analysis, we show that the fourth also overproduces low-affinity receptors. According to slot blot DNA analyses, the secretion of high levels of TGF-α is not associated with amplification of the TGF-α gene, and hyperproduction of the EGF-R is correlated with receptor gene amplification. Western blot analyses show that the c-Myc protein is overexpressed in two of the cell lines; and Southern and Northern blot analyses indicate that this overexpression occurs independently of c-myc gene amplification. Our results are consistent with an autocrine role for TGF-α and EGF-R in oesophageal carcinogenesis and support the possibility that c-myc overexpression may be required for the in vivo tumourigenicity of cells that produce high levels of TGF-α and the EGF-R.

Oesophageal Squamous Cell Carcinoma Screening Among High-Risk Patients: National Prospective Study of the French Digestive Endoscopy Society (SFED)

2004 ◽  
Vol 59 (5) ◽  
pp. P255
Author(s):  
Johann Dubuc ◽  
Jean-Arnaud Seyrig ◽  
Jean-Pierre Barbier ◽  
Thierry Barrioz ◽  
Rene Laugier ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
High Risk ◽  
Prospective Study ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Digestive Endoscopy ◽  
Oesophageal Squamous Cell Carcinoma ◽  
High Risk Patients ◽  
Risk Patients

scholarly journals Elevated levels of serum transforming growth factor-β 1 in oesophageal squamous cell carcinoma patients

2011 ◽  
Vol 3 ◽  
pp. 137-141 ◽  
Author(s):  
Dorota Diakowska ◽  
Andrzej Lewandowski ◽  
Krystyna Markocka-Mączka ◽  
Krzysztof Grabowski
Keyword(s):  
Squamous Cell Carcinoma ◽  
Growth Factor ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Oesophageal Squamous Cell Carcinoma

Contact with animals and risk of oesophageal squamous cell carcinoma: outcome of a case–control study from Kashmir, a high-risk region

2014 ◽  
Vol 71 (3) ◽  
pp. 208-214 ◽  
Author(s):  
Nazir Ahmad Dar ◽  
Farhad Islami ◽  
Gulzar Ahmad Bhat ◽  
Idrees Ayoub Shah ◽  
Muzamil Ashraf Makhdoomi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
High Risk ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Case Control Study ◽  
Case Control ◽  
Oesophageal Squamous Cell Carcinoma ◽  
Control Study

scholarly journals MicroRNA-375 inhibits tumour growth and metastasis in oesophageal squamous cell carcinoma through repressing insulin-like growth factor 1 receptor

Gut ◽  
2011 ◽  
Vol 61 (1) ◽  
pp. 33-42 ◽  
Author(s):  
Kar Lok Kong ◽  
Dora Lai Wan Kwong ◽  
Tim Hon-Man Chan ◽  
Simon Ying-Kit Law ◽  
Leilei Chen ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Growth Factor ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tumour Growth ◽  
Insulin Like Growth Factor ◽  
Oesophageal Squamous Cell Carcinoma

scholarly journals Opium, tobacco, and alcohol use in relation to oesophageal squamous cell carcinoma in a high-risk area of Iran

2008 ◽  
Vol 98 (11) ◽  
pp. 1857-1863 ◽  
Author(s):  
D Nasrollahzadeh ◽  
F Kamangar ◽  
K Aghcheli ◽  
M Sotoudeh ◽  
F Islami ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
High Risk ◽  
Alcohol Use ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oesophageal Squamous Cell Carcinoma ◽  
Risk Area ◽  
High Risk Area

In vitro secretion of transforming growth factor alpha (TGF-α): A comparison of the A431 cell line with three human oesophageal squamous cell carcinoma lines

1992 ◽  
Vol 12 (4) ◽  
pp. 293-302 ◽  
Author(s):  
A. L. Thornley ◽  
G. J. Jones
Keyword(s):  
Squamous Cell Carcinoma ◽  
Growth Factor ◽  
Cell Carcinoma ◽  
Cell Line ◽  
Squamous Cell ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Alpha ◽  
Oesophageal Squamous Cell Carcinoma ◽  
Factor Alpha ◽  
A431 Cell Line

Transforming growth factor alpha (TGF-α) is a single chain polypeptide which exists in a variety of forms differing in molecular weight. These forms are variously present in normal and neoplastic cells. Of particular interest are TGF-α's well-known mitogenic properties. The transition from a normal to a neoplastic cellular state results from signalling defects that may depend upon, iter alia, abonormal levels of expression and secretion of TGF-α. It is known that the secretion of TGF-α may be enhanced appreciably by agents such as phorbol 12-myristate 13-acetate (PMA), serum factors and epidermal growth factor (EGF). Here, we compare the efficacy of these three agents in the elevation of TGF-α secretion in the well studied A431 cell line with their previously undocumented efficacy in certain interesting, but little known, human oesophageal squamous cell carcinoma (SCC) lines.

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