The role of endocannabinoid system and TRPV1 receptors in the antidepressant and anxiolytic effects of dipyrone in chronic unpredictable mild stress in mice

2021 ◽  
pp. 174315
Author(s):  
Ruhan Deniz Topuz ◽  
Mehmet Zahid Cetinkaya ◽  
Dilsat Erumit ◽  
Kubra Duvan Aydemir ◽  
Ozgur Gunduz ◽  
...  
Keyword(s):  
Endocannabinoid System ◽  
Mild Stress ◽  
Chronic Unpredictable Mild Stress ◽  
Trpv1 Receptors

scholarly journals The protective role of musk on salivary glands of mice exposed to chronic unpredictable mild stress

2019 ◽  
Vol 61 (1) ◽  
pp. 95-102 ◽  
Author(s):  
Nasra N. Ayuob ◽  
Hanem S. Abdel-Tawab ◽  
Ahmed A. El-Mansy ◽  
Soad S. Ali
Keyword(s):  
Salivary Glands ◽  
Protective Role ◽  
Mild Stress ◽  
Chronic Unpredictable Mild Stress

Protective effects of morin against depressive-like behavior prompted by chronic unpredictable mild stress in rats: Possible role of inflammasome-related pathways

2020 ◽  
Vol 180 ◽  
pp. 114140
Author(s):  
Mennat-Allah M. Hassan ◽  
Amany M. Gad ◽  
Esther T. Menze ◽  
Osama A. Badary ◽  
Reem N. El-Naga
Keyword(s):  
Mild Stress ◽  
Protective Effects ◽  
Chronic Unpredictable Mild Stress

scholarly journals Curcumin Relieves Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior through the PGC-1α/FNDC5/BDNF Pathway

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Yanqin Wu ◽  
Fusheng Sun ◽  
Yujin Guo ◽  
Yumao Zhang ◽  
Li Li ◽  
...  
Keyword(s):  
Therapeutic Effects ◽  
Peroxisome Proliferator ◽  
Mild Stress ◽  
Chronic Unpredictable Mild Stress ◽  
Peroxisome Proliferator Activated Receptor ◽  
Beneficial Effects ◽  
Regulatory Effects ◽  
Fibronectin Type Iii Domain ◽  
Bdnf Pathway

Background and Aim. Increasing evidence suggests that the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α)/fibronectin type III domain-containing 5 (FNDC5)/brain-derived neurotrophic factor (BDNF) pathway might be critical for neuroprotection. Our present study is aimed at investigating the antidepressant-like effects of curcumin (CUR) in a chronic unpredictable mild stress- (CUMS-) induced depression rat model and explore whether the PGC-1α/FNDC5/BDNF pathway is the major driving force behind the therapeutic effects of CUR. Methods. All rats were randomly divided into four groups, namely, control, CUMS, CUMS + CUR , and CUMS + CUR + SR 18292 (PGC-1α inhibitor). Behavioral tests were conducted to assess the antidepressant-like effects of CUR. The expressions of PGC-1α, estrogen-related receptor alpha (ERRα), FNDC5, and BDNF were determined to investigate the regulatory effects of CUR on the PGC-1α/FNDC5/BDNF pathway. The PGC-1α inhibitor SR18292 was used to explore the role of PGC-1α in the induction of BDNF by CUR. Results. Daily gavage of 100 mg/kg CUR successfully attenuated the abnormal behaviors induced by CUMS and effectively prevented CUMS-induced reduction of PGC-1α, ERRα, FNDC5, and BDNF expressions. CUR also enhanced PGC-1α and ERRα translocation from cytoplasm to nucleus. Furthermore, we found that CUR supplementation effectively promoted neurocyte proliferation and suppressed neuronal apoptosis induced by CUMS. Of note, the PGC-1α inhibitor SR18292 remarkably reversed the beneficial effects of CUR on depressed rats, indicating an important role of PGC-1α in the antidepressant-like effects of CUR. Conclusion. Collectively, our data evaluating the neuroprotective action of CUR in the CUMS rats highlights the involvement of the PGC-1α/FNDC5/BDNF pathway in the antidepressant-like effects of CUR.

scholarly journals Role of hippocampal p11 in the sustained antidepressant effect of ketamine in the chronic unpredictable mild stress model

2016 ◽  
Vol 6 (2) ◽  
pp. e741-e741 ◽  
Author(s):  
H-L Sun ◽  
Z-Q Zhou ◽  
G-F Zhang ◽  
C Yang ◽  
X-M Wang ◽  
...  
Keyword(s):  
Antidepressant Effect ◽  
Mild Stress ◽  
Stress Model ◽  
Chronic Unpredictable Mild Stress

scholarly journals Hydrogen Sulfide Protects against Chronic Unpredictable Mild Stress-Induced Oxidative Stress in Hippocampus by Upregulation of BDNF-TrkB Pathway

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Min Hu ◽  
Wei Zou ◽  
Chun-Yan Wang ◽  
Xi Chen ◽  
Hui-Ying Tan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Hydrogen Sulfide ◽  
Protein Expression ◽  
Mild Stress ◽  
Chronic Unpredictable Mild Stress ◽  
Inhibitory Role ◽  
Bdnf Signaling ◽  
Antioxidant Effects

Chronic unpredictable mild stress (CUMS) induces hippocampal oxidative stress. H2S functions as a neuroprotectant against oxidative stress in brain. We have previously shown the upregulatory effect of H2S on BDNF protein expression in the hippocampus of rats. Therefore, we hypothesized that H2S prevents CUMS-generated oxidative stress by upregulation of BDNF-TrkB pathway. We showed that NaHS (0.03 or 0.1 mmol/kg/day) ameliorates the level of hippocampal oxidative stress, including reduced levels of malondialdehyde (MDA) and 4-hydroxy-2-trans-nonenal (4-HNE), as well as increased level of glutathione (GSH) and activity of superoxide dismutase (SOD) in the hippocampus of CUMS-treated rats. We also found that H2S upregulated the level of BDNF and p-TrkB protein in the hippocampus of CUMS rats. Furthermore, inhibition of BDNF signaling by K252a, an inhibitor of the BDNF receptor TrkB, blocked the antioxidant effects of H2S on CUMS-induced hippocampal oxidative stress. These results reveal the inhibitory role of H2S in CUMS-induced hippocampal oxidative stress, which is through upregulation of BDNF/TrkB pathway.

scholarly journals Effects of Chronic Cannabidiol Treatment in the Rat Chronic Unpredictable Mild Stress Model of Depression

Biomolecules ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 801 ◽  
Author(s):  
Zsolt Gáll ◽  
Szidónia Farkas ◽  
Ákos Albert ◽  
Elek Ferencz ◽  
Szende Vancea ◽  
...  
Keyword(s):  
Body Weight ◽  
Body Weight Gain ◽  
Endocannabinoid System ◽  
Treated Group ◽  
Daily Basis ◽  
Sucrose Preference ◽  
Mild Stress ◽  
Chronic Unpredictable Mild Stress ◽  
Plus Maze ◽  
Male Wistar Rats

Several neuropharmacological actions of cannabidiol (CBD) due to the modulation of the endocannabinoid system as well as direct serotonergic and gamma-aminobutyric acidergic actions have recently been identified. The current study aimed to reveal the effect of a long-term CBD treatment in the chronic unpredictable mild stress (CUMS) model of depression. Adult male Wistar rats (n = 24) were exposed to various stressors on a daily basis in order to induce anhedonia and anxiety-like behaviors. CBD (10 mg/kg body weight) was administered by daily intraperitoneal injections for 28 days (n = 12). The effects of the treatment were assessed on body weight, sucrose preference, and exploratory and anxiety-related behavior in the open field (OF) and elevated plus maze (EPM) tests. Hair corticosterone was also assayed by liquid chromatography–mass spectrometry. At the end of the experiment, CBD-treated rats showed a higher rate of body weight gain (5.94% vs. 0.67%) and sucrose preference compared to controls. A significant increase in vertical exploration and a trend of increase in distance traveled in the OF test were observed in the CBD-treated group compared to the vehicle-treated group. The EPM test did not reveal any differences between the groups. Hair corticosterone levels increased in the CBD-treated group, while they decreased in controls compared to baseline (+36.01% vs. −45.91%). In conclusion, CBD exerted a prohedonic effect in rats subjected to CUMS, demonstrated by the increased sucrose preference after three weeks of treatment. The reversal of the effect of CUMS on hair corticosterone concentrations might also point toward an anxiolytic or antidepressant-like effect of CBD, but this needs further confirmation.

scholarly journals Alterations in Anandamide Synthesis and Degradation during Osteoarthritis Progression in an Animal Model

2020 ◽  
Vol 21 (19) ◽  
pp. 7381
Author(s):  
Marta Bryk ◽  
Jakub Chwastek ◽  
Magdalena Kostrzewa ◽  
Jakub Mlost ◽  
Aleksandra Pędracka ◽  
...  
Keyword(s):  
Gene Expression ◽  
Animal Model ◽  
Endocannabinoid System ◽  
Joint Inflammation ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Lumbar Spinal Cord ◽  
Trpv1 Receptors ◽  
Synthesis And Degradation

Osteoarthritis (OA) is a degenerative joint disease manifested by movement limitations and chronic pain. Endocannabinoid system (ECS) may modulate nociception via cannabinoid and TRPV1 receptors. The purpose of our study was to examine alterations in the spinal and joint endocannabinoid system during pain development in an animal model of OA. Wistar rats received intra-articular injection of 3mg of sodium monoiodoacetate (MIA) into the knee joint. Animals were sacrificed on day 2, 7, 14, 21, 28 after injection and lumbar spinal cord, cartilage and synovium were collected. Changes in the transcription levels of the ECS elements were measured. At the spinal level, gene expression levels of the cannabinoid and TRPV1 receptors as well as enzymes involved in anandamide synthesis and degradation were elevated in the advanced OA phase. In the joint, an important role of the synovium was demonstrated, since cartilage degeneration resulted in attenuation of the changes in the gene expression. Enzymes responsible for anandamide synthesis and degradation were upregulated particularly in the early stages of OA, presumably in response to early local joint inflammation. The presented study provides missing information about the MIA-induced OA model and encourages the development of a therapy focused on the molecular role of ECS.

BDNF prevents central oxidative damage in a chronic unpredictable mild stress model: The possible role of PRDX-1 in anhedonic behavior

2020 ◽  
Vol 378 ◽  
pp. 112245 ◽  
Author(s):  
Ellen Scotton ◽  
Rafael Colombo ◽  
Jéssica C. Reis ◽  
Gabriela M.P. Possebon ◽  
Gabriel H. Hizo ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Mild Stress ◽  
Stress Model ◽  
Chronic Unpredictable Mild Stress
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