Up-regulation of Nrf2/P62/Keap1 involves in the anti-fibrotic effect of combination of monoammonium glycyrrhizinate and cysteine hydrochloride induced by CCl4

2021 ◽  
pp. 174628
Author(s):  
Shifeng Chu ◽  
Haozhi Bi ◽  
Xinyu Li ◽  
Liyuan Cui ◽  
Wenbin He ◽  
...  
Keyword(s):  
Cysteine Hydrochloride

NEW COLOR REACTIONS OF SEDOHEPTULOSAN AND ITS DETERMINATION IN MIXTURES OF RIBOSE AND FRUCTOSE

1954 ◽  
Vol 32 (1) ◽  
pp. 14-18 ◽  
Author(s):  
L. Ujejski ◽  
E. R. Waygood
Keyword(s):  
Sulphuric Acid ◽  
Colorimetric Determination ◽  
Pure Solution ◽  
Naturally Occurring ◽  
Cysteine Hydrochloride ◽  
Color Reactions

The reagents carbazole – sulphuric acid, cysteine hydrochloride – sulphuric acid, have been applied successfully to the quantitative colorimetric determination of sedoheptulosan in pure solution or in the presence of ribose and/or fructose. Fructose can be determined quantitatively in the presence of sedoheptulosan and/or ribose by using a combination of the two reagents. Results indicate that while sedoheptulose reacts differently to sedoheptulosan with the orcinol reagent, the reactions with carbazole and cysteine are not altered by hydration and these may form a basis for the determination of the naturally occurring seven carbon sugar sedoheptulose.

Thiolated Eudragit-Coated Chitosan Microspheres as an Oral Drug Delivery System

2007 ◽  
Vol 342-343 ◽  
pp. 445-448 ◽  
Author(s):  
Ji Shan Quan ◽  
Hu Lin Jiang ◽  
Yun Jaie Choi ◽  
Mi Kyong Yoo ◽  
Chong Su Cho
Keyword(s):  
Oral Delivery ◽  
Oral Drug Delivery ◽  
In Vitro Release ◽  
Oral Drug ◽  
Average Particle ◽  
Protein Drug ◽  
Chitosan Microspheres ◽  
Oral Drug Delivery System ◽  
Cysteine Hydrochloride

The aim of this study is to prepare mucoadhesive chitosan microspheres for protein drug to deliver to intestine through oral administration. The thiolated Eudragit was synthesized by reaction between L-cysteine hydrochloride and Eudragit® L-100. About 8 mol-% of cysteine was introduced to the Eudragit-cysteine conjugate. The conjugate was used to coat bovine serum albumin (BSA)-loaded chitosan microspheres. The average particle sizes of BSA-loaded thiolated Eudragit-coated chitsoan microspheres (TECMs) were 4.06±0.74 .m and the uniform sizedistribution was shown. The in vitro release of BSA from BSA-loaded TECMs was pH-dependent. Our results indicated that thiolated Eudragit might be a good candidate as a coating material for oral delivery of protein drug owing to mucoadhesive and pH-sensitive properties.

Primary isolation media for Legionnaires disease bacterium

1978 ◽  
Vol 8 (3) ◽  
pp. 320-325 ◽  
Author(s):  
J C Feeley ◽  
G W Gorman ◽  
R E Weaver ◽  
D C Mackel ◽  
H W Smith
Keyword(s):  
Oxygen Tension ◽  
Primary Isolation ◽  
Ferric Pyrophosphate ◽  
Mueller Hinton ◽  
Cysteine Hydrochloride ◽  
Mueller Hinton Agar ◽  
Agar Media ◽  
Legionnaires Disease ◽  
Isolation Media ◽  
Different Cultures

Yolk sac suspensions infected with the Legionnaires disease bacterium (LDB) were plated onto 17 different bacteriological agar media. The LDB grew only on Mueller-Hinton agar supplemented with 1% Iso Vitale X and 1% hemoglobin (MH-IH). This medium was subsequently analyzed to determine the components required to support growth of the LDB. L-Cysteine hydrochloride can replace the Iso Vitale X reagent, and soluble ferric pyrophosphate can replace hemoglobin. A new medium, F-G agar, was formulated incorporating these chemicals. Different cultures conditions (oxygen tension, temperature, and pH) were also evaluated. The LDB grew optimally at 35 degrees C under 2.5% CO2 on the F-G agar adjusted to pH 6.9. When infected tissues were inoculated onto both F-G agar and MH-IH, the F-G agar produced colonies of the LDB more rapidly and in greater numbers than did MH-IH.

MODIFICATION OF OZONE DAMAGE TO PHASEOLUS VULGARIS BY ANTIOXIDANTS, THIOLS AND SULFHYDRYL REAGENTS

1968 ◽  
Vol 48 (6) ◽  
pp. 569-574 ◽  
Author(s):  
H. C. Dass ◽  
G. M. Weaver
Keyword(s):  
Ascorbic Acid ◽  
Phaseolus Vulgaris ◽  
Lactic Dehydrogenase ◽  
Sulfhydryl Reagents ◽  
Thiol Compounds ◽  
Ozone Injury ◽  
Ozone Sensitivity ◽  
Cysteine Hydrochloride ◽  
White Bean

Representative cultivars of white bean (Phaseolus vulgaris) were treated with selected antioxidants, thiol compounds and sulfhydryl reagents and then exposed to ozone under laboratory conditions. Severity of the bronzing disorder was influenced by such treatments, as was the activity of peroxidase and lactic dehydrogenase enzymes.Dust applications of ascorbic acid and nickel-N-dibutyl dithiocarbamate markedly reduced ozone injury, the latter compound being the most effective. Decreased ozone sensitivity was also noted following treatment of a susceptible and a tolerant cultivar with cysteine hydrochloride and glutathione.The severity of bronzing was increased over that of the control plants by the application of sulfhydryl reagents, namely parachloromercuribenzoate and N-ethyl maleimide. Necrotic stipple of the upper surface of the lamina, a symptom associated with the bronzing disorder, was induced following treatment with the sulfhydryl reagents without exposure to ozone.Ozone fumigation increased peroxidase activity and decreased lactic dehydrogenase activity. Similar effects were observed following treatment with parachloromercuribenzoate. Neither enzyme showed response to the application of cysteine hydrochloride.The role of protein sulfhydryls is discussed in relation to ozone damage and the bronzing disorder.

Trichostrongylosis and wool growth. 2. The wool growth response of infected sheep to parenteral and duodenal cystine and cysteine supplementation

1973 ◽  
Vol 13 (63) ◽  
pp. 351 ◽  
Author(s):  
IA Barger ◽  
WH Southcott ◽  
VJ Williams
Keyword(s):  
Growth Rate ◽  
Growth Rates ◽  
Growth Response ◽  
Infected Sheep ◽  
Trichostrongylus Colubriformis ◽  
Intestinal Nematode ◽  
Wool Growth ◽  
Cysteine Hydrochloride ◽  
Significant Difference ◽  
Maintenance Ration

Two experiments are reported. In experiment 1, light infections with the intestinal nematode Trichostrongylus colubriformis reduced wool growth of sheep by 42 per cent compared with pair-fed controls. There was no significant difference in wool growth between those sheep given a cystine supplement as an intraperitoneal pellet and those given a daily intra-duodenal injection of cystine, although cystine was poorly absorbed from the peritoneal cavity. In experiment 2, fifteen sheep were fed a maintenance ration and their wool growth rates defined. When six of the sheep were given a daily intra-duodenal drip containing 2 g cysteine hydrochloride, and six sheep were given the same drip intravenously, their wool growth rate increased by a mean of 33 per cent compared with the wool growth of the three untreated sheep, irrespective of the route of administration of the cysteine. Three sheep in each group of six were then lightly infected with Trichostrongylus colubriformis and the wool production of all sheep was measured in the presence and absence of the daily cysteine supplement via the two routes. The infection depressed wool growth, but did not influence the wool growth response to either route of cysteine supplementation. It was concluded that the reduced wool growth induced by trichostrongylosis could not be attributed to malabsorption of cysteine. Evidence was obtained that sheep resistant to Trichostrongylus colubriformis produced less wool when subjected to a larval challenge.

Enhancement of Ethylenethiourea Recoveries in Food Analyses by Addition of Cysteine Hydrochloride

1995 ◽  
Vol 78 (4) ◽  
pp. 1097-1101 ◽  
Author(s):  
Chris A Sack
Keyword(s):  
Hydrogen Peroxide ◽  
Sodium Sulfite ◽  
Frozen Storage ◽  
Food Product ◽  
The Other ◽  
Butylated Hydroxytoluene ◽  
Butylated Hydroxyanisole ◽  
Food Items ◽  
Cysteine Hydrochloride ◽  
Vitamins A And C

Abstract The effectiveness of cysteine hydrochloride (Cys–HCI) as a preservative of ethylenethiourea (ETU) in product matrixes and during analysis was studied. ETU recoveries were adversely affected by certain product matrixes when fortified directly into the product. Recoveries in 8 selected food items were 0–92% when analyzed 30 min after fortification and 0–51% when analyzed after 24 h. When Cys–HCI was added to product prior to fortification, recoveries increased to 71–95% even after frozen storage for 2–4 weeks. Cys–HCI was added during analysis of 53 untreated items. Recoveries improved an average of 15% with Cys–HCI. Without Cys–HCI, recoveries were erratic (20–98%), but with Cys–HCI, recoveries were 68–113%. Other antioxidants (sodium sulfite, butylated hydroxyanisole, butylated hydroxytoluene, and vitamins A and C) also were evaluated as ETU preservatives. When lettuce was treated first with sodium sulfite and then fortified with ETU, recoveries averaged 86%; without sodium sulfite, they averaged 1%. The other antioxidants were less effective for preserving ETU in lettuce, giving only 8–46% recoveries. The effect of oxidizers (potassium bromate, sodium hypochlorite, and hydrogen peroxide) on ETU recovery was also determined. Recovery of ETU from a baby food product (pears and pineapple) was 82%; with oxidizers, recoveries were 0–8%.

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