Synthesis and evaluation of mono- and multi-hydroxyl low toxicity pH-sensitive cationic lipids for drug delivery

2019 ◽  
Vol 133 ◽  
pp. 69-78 ◽  
Author(s):  
Zheng Zhao ◽  
Weihe Yao ◽  
Ning Wang ◽  
Chenyu Liu ◽  
Hengjun Zhou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Sensitive ◽  
Cationic Lipids ◽  
Low Toxicity

pH-sensitive polymers for drug delivery

2012 ◽  
Vol 20 (3) ◽  
pp. 224-233 ◽  
Author(s):  
Kang Moo Huh ◽  
Han Chang Kang ◽  
Young Ju Lee ◽  
You Han Bae
Keyword(s):  
Drug Delivery ◽  
Ph Sensitive

scholarly journals Genipin as An Emergent Tool in the Design of Biocatalysts: Mechanism of Reaction and Applications

Catalysts ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 1035 ◽  
Author(s):  
Veymar G. Tacias-Pascacio ◽  
Esmeralda García-Parra ◽  
Gilber Vela-Gutiérrez ◽  
Jose J. Virgen-Ortiz ◽  
Ángel Berenguer-Murcia ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Drug Delivery ◽  
Medical Applications ◽  
Fruit Extract ◽  
Biological Scaffolds ◽  
Gardenia Jasminoides ◽  
Mechanism Of Reaction ◽  
Low Toxicity ◽  
Activating Agent ◽  
The Stability

Genipin is a reagent isolated from the Gardenia jasminoides fruit extract, and whose low toxicity and good crosslinking properties have converted it into a reactive whose popularity is increasing by the day. These properties have made it widely used in many medical applications, mainly in the production of chitosan materials (crosslinked by this reactive), biological scaffolds for tissue engineering, and nanoparticles of chitosan and nanogels of proteins for controlled drug delivery, the genipin crosslinking being a key point to strengthen the stability of these materials. This review is focused on the mechanism of reaction of this reagent and its use in the design of biocatalysts, where genipin plays a double role, as a support activating agent and as inter- or intramolecular crosslinker. Its low toxicity makes this compound an ideal alterative to glutaraldehyde in these processes. Moreover, in some cases the features of the biocatalysts prepared using genipin surpassed those of the biocatalysts prepared using other standard crosslinkers, even disregarding toxicity. In this way, genipin is a very promising reagent in the design of biocatalysts.

A novel high drug loading mussel-inspired polydopamine hybrid nanoparticle as a pH-sensitive vehicle for drug delivery

2017 ◽  
Vol 533 (1) ◽  
pp. 73-83 ◽  
Author(s):  
Jie Hou ◽  
Chunlei Guo ◽  
Yuzhi Shi ◽  
Ergang Liu ◽  
Weibing Dong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Loading ◽  
Ph Sensitive ◽  
High Drug ◽  
Hybrid Nanoparticle ◽  
High Drug Loading

pH-sensitive polyion complex micelles for tunable intracellular drug delivery

2015 ◽  
Vol 213 ◽  
pp. e55
Author(s):  
Jinjin Chen ◽  
Ying Zhang ◽  
Jianxun Ding ◽  
Chunsheng Xiao ◽  
Xiuli Zhuang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Sensitive ◽  
Polyion Complex ◽  
Polyion Complex Micelles ◽  
Intracellular Drug Delivery ◽  
Complex Micelles

scholarly journals A review of mechanistic insight and application of pH-sensitive liposomes in drug delivery

Drug Delivery ◽  
2014 ◽  
Vol 22 (3) ◽  
pp. 231-242 ◽  
Author(s):  
Shivani Rai Paliwal ◽  
Rishi Paliwal ◽  
Suresh P. Vyas
Keyword(s):  
Drug Delivery ◽  
Ph Sensitive ◽  
Mechanistic Insight

pH-Sensitive ZnO Quantum Dots–Doxorubicin Nanoparticles for Lung Cancer Targeted Drug Delivery

2016 ◽  
Vol 8 (34) ◽  
pp. 22442-22450 ◽  
Author(s):  
Xiaoli Cai ◽  
Yanan Luo ◽  
Weiying Zhang ◽  
Dan Du ◽  
Yuehe Lin
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Quantum Dots ◽  
Targeted Drug Delivery ◽  
Ph Sensitive ◽  
Targeted Drug ◽  
Zno Quantum Dots
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