SUN-137 PREVALENCE OF CHRONIC KIDNEY DISEASE MARKERS IN SAUDI ARABIA: POPULATION BASED PILOT STUDY

We investigated the association between dietary micronutrient intakes and the risk of chronic kidney disease (CKD) in the Ansan-Ansung study of the Korean Genome and Epidemiologic Study (KoGES), a population-based prospective cohort study. Of 9079 cohort participants with a baseline estimate glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 and a urine albumin to creatinine ratio (UACR) <300 mg/g and who were not diagnosed with CKD, we ascertained 1392 new CKD cases over 12 year follow-up periods. The risk of CKD according to dietary micronutrient intakes was presented using hazard ratios (HRs) and 95% confidence intervals (95% CIs) in a full multivariable Cox proportional hazard models, adjusted for multiple micronutrients and important clinico-epidemiological risk factors. Low dietary intakes of phosphorus (<400 mg/day), vitamin B2 (<0.7 mg/day) and high dietary intake of vitamin B6 (≥1.6 mg/day) and C (≥100 mg/day) were associated with an increased risk of CKD stage 3B and over, compared with the intake at recommended levels (HR = 6.78 [95%CI = 2.18–21.11]; HR = 2.90 [95%CI = 1.01–8.33]; HR = 2.71 [95%CI = 1.26–5.81]; HR = 1.83 [95%CI = 1.00–3.33], respectively). In the restricted population, excluding new CKD cases defined within 2 years, an additional association with low folate levels (<100 µg/day) in higher risk of CKD stage 3B and over was observed (HR = 6.72 [95%CI = 1.40–32.16]). None of the micronutrients showed a significant association with the risk of developing CKD stage 3A. Adequate intake of micronutrients may lower the risk of CKD stage 3B and over, suggesting that dietary guidelines are needed in the general population to prevent CKD.

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Inflammatory Skin Diseases and the Risk of Chronic Kidney Disease – Population‐Based Case‐control and Cohort analyses

British Journal of Dermatology ◽

10.1111/bjd.20067 ◽

2021 ◽

Author(s):

Y. Schonmann ◽

K.E. Mansfield ◽

A. Mulick ◽

A. Roberts ◽

L. Smeeth ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Skin Diseases ◽

Population Based ◽

Case Control ◽

Inflammatory Skin Diseases ◽

Chronic Kidney Disease Population ◽

Inflammatory Skin ◽

Cohort Analyses

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Association of Individual Non-Steroidal Anti-Inflammatory Drugs and Chronic Kidney Disease: A Population-Based Case Control Study

PLoS ONE ◽

10.1371/journal.pone.0122899 ◽

2015 ◽

Vol 10 (4) ◽

pp. e0122899 ◽

Cited By ~ 35

Author(s):

Ylenia Ingrasciotta ◽

Janet Sultana ◽

Francesco Giorgianni ◽

Andrea Fontana ◽

Antonio Santangelo ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Control Study

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High prevalence of chronic kidney disease in Iran: a large population-based study

BMC Public Health ◽

10.1186/1471-2458-9-44 ◽

2009 ◽

Vol 9 (1) ◽

Cited By ~ 51

Author(s):

Farhad Hosseinpanah ◽

Farshad Kasraei ◽

Amir A Nassiri ◽

Fereidoun Azizi

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Large Population ◽

Population Based ◽

Population Based Study ◽

High Prevalence

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Predictors of Declining Glomerular Filtration Rate in a Population-Based Chronic Kidney Disease Cohort

Nephron Clinical Practice ◽

10.1159/000286349 ◽

2010 ◽

Vol 115 (1) ◽

pp. c41-c50 ◽

Cited By ~ 17

Author(s):

Bjørn O. Eriksen ◽

Janne Tomtum ◽

Ole C. Ingebretsen

Keyword(s):

Chronic Kidney Disease ◽

Glomerular Filtration Rate ◽

Kidney Disease ◽

Glomerular Filtration ◽

Filtration Rate ◽

Population Based

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Obesity, Abdominal Obesity and Chronic Kidney Disease in Young Adults: A Nationwide Population-Based Cohort Study

Journal of Clinical Medicine ◽

10.3390/jcm10051065 ◽

2021 ◽

Vol 10 (5) ◽

pp. 1065

Author(s):

Eun Hui Bae ◽

Sang Yeob Lim ◽

Jin-Hyung Jung ◽

Tae Ryom Oh ◽

Hong Sang Choi ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Young Adults ◽

Kidney Disease ◽

Abdominal Obesity ◽

Population Based ◽

Baseline Body Mass Index ◽

Increased Risk ◽

Baseline Examination ◽

New Onset

Obesity has become a pandemic. It is one of the strongest risk-factors of new-onset chronic kidney disease (CKD). However, the effects of obesity and abdominal obesity on the risk of developing CKD in young adults has not been elucidated. From a nationwide health screening database, we included 3,030,884 young adults aged 20–39 years without CKD during a baseline examination in 2009–2010, who could follow up during 2013–2016. Patients were stratified into five levels based on their baseline body mass index (BMI) and six levels based on their waist circumference (WC; 5-cm increments). The primary outcome was the development of CKD. During the follow up, until 2016, 5853 (0.19%) participants developed CKD. Both BMI and WC showed a U-shaped relationship with CKD risk, identifying the cut-off values as a BMI of 21 and WC of 72 cm in young adults. The obesity group (odd ratio [OR] = 1.320, 95% confidence interval [CI]: 1.247–1.397) and abdominal obesity group (male WC ≥ 90, female WC ≥ 85) (OR = 1.208, 95%CI: 1.332–1.290) showed a higher CKD risk than the non-obesity or non-abdominal obesity groups after adjusting for covariates. In the CKD risk by obesity composite, the obesity displayed by the abdominal obesity group showed the highest CKD risk (OR = 1.502, 95%CI: 1.190–1.895), especially in those under 30 years old. During subgroup analysis, the diabetes mellitus (DM) group with obesity or abdominal obesity paradoxically showed a lower CKD risk compared with the non-obesity or non-abdominal obesity group. Obesity and abdominal obesity are associated with increased risk of developing CKD in young adults but a decreased risk in young adults with diabetes.

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Optimal blood pressure for patients with chronic kidney disease: a nationwide population-based cohort study

Scientific Reports ◽

10.1038/s41598-021-81328-y ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

You-Bin Lee ◽

Ji Sung Lee ◽

So-hyeon Hong ◽

Jung A. Kim ◽

Eun Roh ◽

...

Keyword(s):

Blood Pressure ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Cardiovascular Events ◽

Antihypertensive Treatment ◽

Antihypertensive Agents ◽

Population Based ◽

Adverse Outcomes ◽

Optimal Blood Pressure ◽

Stage Renal Disease

AbstractThe effect of blood pressure (BP) on the incident cardiovascular events, progression to end-stage renal disease (ESRD) and mortality were evaluated among chronic kidney disease (CKD) patients with and without antihypertensive treatment. This nationwide study used the Korean National Health Insurance Service-Health Screening Cohort data. The hazards of outcomes were analysed according to the systolic BP (SBP) or diastolic BP (DBP) among adults (aged ≥ 40 years) with CKD and without previous cardiovascular disease or ESRD (n = 22,278). The SBP and DBP were ≥ 130 mmHg and ≥ 80 mmHg in 10,809 (48.52%) and 11,583 (51.99%) participants, respectively. During a median 6.2 years, 1271 cardiovascular events, 201 ESRD incidents, and 1061 deaths were noted. Individuals with SBP ≥ 130 mmHg and DBP ≥ 80 mmHg had higher hazards of hypertension-related adverse outcomes compared to the references (SBP 120–129 mmHg and DBP 70–79 mmHg). SBP < 100 mmHg was associated with hazards of all-cause death, and composite of ESRD and all-cause death during follow-up only among the antihypertensive medication users suggesting that the BP should be < 130/80 mmHg and the SBP should not be < 100 mmHg with antihypertensive agents to prevent the adverse outcome risk of insufficient and excessive antihypertensive treatment in CKD patients.

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