Laponite based nanomaterials (LBNMs) are highly diverse regarding their mechanical, chemical, and
structural properties, coupled with shape, size, mass, biodegradability and biocompatibility. These ubiquitous
properties of LBNMs make them appropriate materials for extensive applications. These have enormous potential
for effective and targeted drug delivery comprised of numerous biodegradable materials which results in enhanced
bioavailability. Moreover, the clay material has been explored in tissue engineering and bioimaging for
the diagnosis and treatment of various diseases. The material has been profoundly explored for minimized toxicity
of nanomedicines. The present review compiled relevant and informative data to focus on the interactions of
laponite nanoparticles and application in drug delivery, tissue engineering, imaging, cell adhesion and proliferation,
and in biosensors. Eventually, concise conclusions are drawn concerning biomedical applications and identification
of new promising research directions.