This study focuses on a super-large bridge in mountainous terrain. Through field measurement, it explored the wind environment characteristics on the location of this bridge, simulated the three-dimensional wind field of long-span half-through arch bridge, and deduced the motion equation and amplitude expression formula of the vortex-induced vibration of large-span half-through arch bridge. By numerical analysis, the vortex-induced vibration response values in completion state and maximum cantilever state are calculated.