scholarly journals Mercury exposure, serum antinuclear/antinucleolar antibodies, and serum cytokine levels in mining populations in Amazonian Brazil: A cross-sectional study

2010 ◽  
Vol 110 (4) ◽  
pp. 345-354 ◽  
Author(s):  
Renee M. Gardner ◽  
Jennifer F. Nyland ◽  
Ines A. Silva ◽  
Ana Maria Ventura ◽  
Jose Maria de Souza ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Mercury Exposure ◽  
Sectional Study ◽  
Serum Cytokine ◽  
Cross Sectional ◽  
Cytokine Levels ◽  
Amazonian Brazil

scholarly journals Serum Cytokine Levels and Their Relation to Clinical Features in Patients with Autoimmune Liver Diseases

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Dilyara Akberova ◽  
Andrei P. Kiassov ◽  
Diana Abdulganieva
Keyword(s):  
Liver Diseases ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Overlap Syndrome ◽  
Sectional Study ◽  
Serum Cytokine ◽  
Cross Sectional ◽  
Autoimmune Liver Diseases ◽  
Cytokine Levels ◽  
Adjusted Logistic Regression

Serum cytokine levels were explored in a combined group of patients with autoimmune liver diseases (AILDs) and separately in patients with autoimmune hepatitis (AIH) and overlap syndrome. Overall, 60 patients with AILD, among them 32 patients with AIH and 28 patients with overlap syndrome, were included in the cross-sectional study. Serum cytokine levels were measured at baseline and compared to those of 21 healthy controls. Patients with AILD had significantly higher levels of IL-6 (0.70 (range 0.17–99.86) in patients with AILD compared to 0.40 (range 0.14–2.65) in controls,p<0.01), IL-8 (1.66 (0.45–34.58) versus 0.53 (0.35–2.38), resp.,p<0.01), and TNF-α(2.61 (0.23–120.88) versus 1.65 (0.21–7.54), resp.,p<0.01). Adjusted logistic regression analysis revealed a pronounced relation of IL-8 and AILD, 48.36 (3.63–643.60), as well as AIH, 18.54 (1.08–318.54), and overlap syndrome, 23.85 (2.37–240.23), while the associations between the level of other cytokines and AILD were assessed as nonsignificant. In the language of absolute numbers, the increase of IL-8 serum level by 1 pg/mL had increased the chance for a patient to find himself in a group of AILD by 48.36 times. Also, high IL-8 serum levels were strongly related to clinical parameters.

scholarly journals Novel biomarkers of mercury-induced autoimmune dysfunction: A cross-sectional study in Amazonian Brazil

2014 ◽  
Vol 132 ◽  
pp. 12-18 ◽  
Author(s):  
Jonathan A. Motts ◽  
Devon L. Shirley ◽  
Ellen K. Silbergeld ◽  
Jennifer F. Nyland
Keyword(s):  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Novel Biomarkers ◽  
Amazonian Brazil

Downregulation of IL-2 and IL-23 in Cervical Biopsies of Cervical Intraepithelial Lesions: A Cross-Sectional Study

2020 ◽  
Vol 64 (5) ◽  
pp. 442-451
Author(s):  
Caetano Galvão Petrini ◽  
Larissa Brito Bastos ◽  
Geraldo Duarte ◽  
Patricia Pereira Dos Santos Melli ◽  
José Carlos Alves-Filho ◽  
...  
Keyword(s):  
Immune Response ◽  
Cross Sectional Study ◽  
Low Grade ◽  
Sectional Study ◽  
Cross Sectional ◽  
Cervical Biopsy ◽  
Biopsy Specimens ◽  
Cytokine Levels ◽  
Intraepithelial Lesion ◽  
Intraepithelial Lesions

Introduction: Persistent infection with high-risk human papillomavirus (HPV) types is associated with high-grade intraepithelial lesions (HSILs) and invasive cervical cancer. The host immune response plays a key role in whether HPV clears or persists. Most studies on local immune response to HPV collect cervical mucus in order to quantify secreted cytokines; however, cells located inside the tissue can release different cytokines associated with HPV infection. Objective: This study compared the cytokine levels in cervical biopsy specimens of women with abnormal colposcopic findings according to the histopathological results: low-grade intraepithelial lesion (LSIL), HSIL, and no intraepithelial lesion (NSIL). Methods: A cross-sectional study enrolling 141 cervical biopsy specimens examined the cytokine profile for interleukin (IL-) 2, IL-4, IL-10, IL-12, IL-17, and IL-23 and interferon-γ, using the Luminex assay/ELISA. Differences in cytokine levels among the cervical lesion groups were assessed using the Kruskal-Wallis test. Results: The 141 specimens included 90 HSILs, 22 LSILs, and 29 NSILs. IL-2 levels were significantly higher in NSIL samples than in LSIL or in HSIL samples (p = 0.0001) and IL-23 levels were significantly higher in NSIL than in HSIL samples (p = 0.003). Conclusions: Our study shows that in samples from the lesion site point, 2 important pro-inflammatory cytokines, IL-2 and IL-23, are downregulated in HPV lesions.

scholarly journals Association of Sicca Syndrome with Proviral Load and Proinflammatory Cytokines in HTLV-1 Infection

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Clara Mônica Lima ◽  
Silvane Santos ◽  
Adriana Dourado ◽  
Natália B. Carvalho ◽  
Valéria Bittencourt ◽  
...  
Keyword(s):  
Proviral Load ◽  
Cross Sectional Study ◽  
Sicca Syndrome ◽  
Sectional Study ◽  
Cross Sectional ◽  
Dry Eyes ◽  
Antigen B ◽  
Cytokine Levels ◽  
Immunological Factors

TheSjögrensyndrome has been diagnosed in patients with HTLV-1 associated myelopathy and dry mouth and dry eyes are documented in HTLV-1 carriers. However the diagnosis ofSjögrensyndrome in these subjects has been contested. In this cross-sectional study, we evaluated the role of immunological factors and proviral load, in sicca syndrome associated with HTLV-1 in patients without myelopathy. Subjects were recruited in the HTLV-1 Clinic, from 2009 to 2011. The proviral load and cytokine levels (IFN-γ, TNF-α, IL-5, and IL-10) were obtained from a database containing the values presented by the subjects at admission in the clinic. Of the 272 participants, 59 (21.7%) had sicca syndrome and in all of them anti-Sjögrensyndrome related antigen A (SSA) and antigen B (SSB) were negatives. The production of TNF-αand IFN-γwas higher in the group with sicca syndrome (P<0.05) than in HTLV-1 infected subjects without sicca syndrome. Our data indicates that patients with sicca syndrome associated with HTLV-1 do not haveSjögrensyndrome. However the increased production of TNF-αand IFN-γin this group of patients may contribute to the pathogenesis of sicca syndrome associated with HTLV-1.

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