Serum Cytokine Levels and Their Relation to Clinical Features in Patients with Autoimmune Liver Diseases

Serum cytokine levels were explored in a combined group of patients with autoimmune liver diseases (AILDs) and separately in patients with autoimmune hepatitis (AIH) and overlap syndrome. Overall, 60 patients with AILD, among them 32 patients with AIH and 28 patients with overlap syndrome, were included in the cross-sectional study. Serum cytokine levels were measured at baseline and compared to those of 21 healthy controls. Patients with AILD had significantly higher levels of IL-6 (0.70 (range 0.17–99.86) in patients with AILD compared to 0.40 (range 0.14–2.65) in controls,p<0.01), IL-8 (1.66 (0.45–34.58) versus 0.53 (0.35–2.38), resp.,p<0.01), and TNF-α(2.61 (0.23–120.88) versus 1.65 (0.21–7.54), resp.,p<0.01). Adjusted logistic regression analysis revealed a pronounced relation of IL-8 and AILD, 48.36 (3.63–643.60), as well as AIH, 18.54 (1.08–318.54), and overlap syndrome, 23.85 (2.37–240.23), while the associations between the level of other cytokines and AILD were assessed as nonsignificant. In the language of absolute numbers, the increase of IL-8 serum level by 1 pg/mL had increased the chance for a patient to find himself in a group of AILD by 48.36 times. Also, high IL-8 serum levels were strongly related to clinical parameters.

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Mercury exposure, serum antinuclear/antinucleolar antibodies, and serum cytokine levels in mining populations in Amazonian Brazil: A cross-sectional study

Environmental Research ◽

10.1016/j.envres.2010.02.001 ◽

2010 ◽

Vol 110 (4) ◽

pp. 345-354 ◽

Cited By ~ 109

Author(s):

Renee M. Gardner ◽

Jennifer F. Nyland ◽

Ines A. Silva ◽

Ana Maria Ventura ◽

Jose Maria de Souza ◽

...

Keyword(s):

Cross Sectional Study ◽

Mercury Exposure ◽

Sectional Study ◽

Serum Cytokine ◽

Cross Sectional ◽

Cytokine Levels ◽

Amazonian Brazil

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Mercury exposure, serum antinuclear antibodies, and serum cytokine levels in the Long Island Study of Seafood Consumption: A cross-sectional study in NY, USA

Environmental Research ◽

10.1016/j.envres.2017.03.037 ◽

2017 ◽

Vol 156 ◽

pp. 334-340 ◽

Cited By ~ 9

Author(s):

Rebecca N. Monastero ◽

Roxanne Karimi ◽

Jennifer F. Nyland ◽

James Harrington ◽

Keith Levine ◽

...

Keyword(s):

Antinuclear Antibodies ◽

Long Island ◽

Cross Sectional Study ◽

Mercury Exposure ◽

Seafood Consumption ◽

Sectional Study ◽

Serum Cytokine ◽

Cross Sectional ◽

Cytokine Levels

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Evaluation of the Blood Level of Adiponectin in Pregnant Adolescents

Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics ◽

10.1055/s-0041-1730288 ◽

2021 ◽

Vol 43 (06) ◽

pp. 429-435

Author(s):

Elaine Cristina Rocha Pádua ◽

Silvia Daher ◽

Isa de Pádua Cintra Sampaio ◽

Edward Araujo Júnior ◽

Cristina Falbo Guazzelli

Keyword(s):

Serum Levels ◽

Cross Sectional Study ◽

Serum Adiponectin ◽

Enzyme Linked Immunosorbent Assay ◽

Sectional Study ◽

Pregnant Adolescents ◽

Cross Sectional ◽

Adolescent Group ◽

Gestational Weight ◽

Intergroup Comparison

Abstract Objective To evaluate serum levels of adiponectin in pregnant adolescents between 30 and 36 weeks of gestation. Method: A prospective cross-sectional study enrolled 67 normal pregnant women between 30 and 36 weeks of gestation and eutrophic (body mass index [BMI]: 18.5–25 kg/m2), of which 36 were adolescents (< 20 years old) and 31 adults (≥ 20 years old). Serum adiponectin levels were determined by enzyme-linked immunosorbent assay (ELISA). The t-student or Mann-Whitney tests were used for intergroup comparison. Results Pregnant adolescents showed significantly higher serum adiponectin concentrations compared with pregnant adults (p = 0.04). No differences were observed in adiponectin levels in younger pregnant adolescents (< 16 years old) compared with older pregnant adolescents (≥ 16 years old). Adiponectin values were divided into 3 subgroups: < 3,000 ng/mL, between 3,000 and 5,000 ng/mL, and > 5,000 ng/mL. Birthweight was significantly higher in women > 5,000 ng/mL when compared with < 3,000 ng/mL in the adolescent group. No association between pregestational adiponectin levels and BMI, gestational weight gain, and gestational age was observed; however, there was a positive relation with birthweight (p = 0.0239). Conclusion Serum adiponectin values in pregnant adolescents between 30 and 36 weeks of gestation were higher compared with pregnant adults; however, no differences between younger and older pregnant adolescents were observed.

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