Corrigendum to “Zearalenone impairs the male reproductive system functions via inducing structural and functional alterations of sertoli cells” [Environ. Toxicol. Pharmacol. 42 (2016) 146–155]

Zearalenone (ZEA) interferes with the function of the male reproductive system, but its molecular mechanism has yet to be completely elucidated. Sertoli cells (SCs) are important in the male reproductive system. Silencing information regulator 1 (SIRT1) is a cell metabolism sensor and resveratrol (RSV) is an activator of SIRT1. In this study we investigated whether SIRT1 is involved in the regulation of ZEA-induced lactate metabolism disorder in SCs. The results showed that the cytotoxicity of ZEA toward SCs increased with increasing ZEA concentration. Moreover, ZEA induced a decrease in the production of lactic acid and pyruvate of SCs and inhibited the expression of glycolytic genes and lactic acid production-related proteins. ZEA also led to a decreased expression of SIRT1 in energy receptors and decreased ATP levels in SCs. However, the ZEA-induced cytotoxicity and decline in lactic acid production in SCs were alleviated by the use of RSV, which is an activator of SIRT1. In summary, ZEA decreased lactic acid production in SCs, while the treatment with an SIRT1 activator, RSV, restored the inhibition of lactic acid production in SCs and reduced cytotoxicity of ZEA toward SCs.

Download Full-text

Pathogenic effect of bunt wheat on male reproductive system in Mices.

The Iraqi Journal of Veterinary Medicine ◽

10.30539/iraqijvm.v34i2.628 ◽

2010 ◽

Vol 34 (2) ◽

pp. 9-14

Author(s):

Mustafa A.K. Al-Taie

Keyword(s):

Experimental Study ◽

Basement Membrane ◽

Sertoli Cells ◽

Reproductive System ◽

Seminiferous Tubule ◽

Male Fertility ◽

Normal Diet ◽

Male Reproductive System ◽

The Other ◽

Histopathological Study

This study was carried out to study the toxic effect of smut wheat on male reproductive system of mice. The experimental study was performed in the laboratory using 20 mice, which divided into two groups, one group feed on normal diet, the other fed on a mixture of 50% normal diet with 50% smut wheat. A histopathological study was done on the testes of Mice fed on smut wheat for 30 days. The histopathological study revealed thickness of basement membrane of semiriferous tubule of mice, and desquamation of the sertoli cells and spermatogonium from the basement membrane of seminiferous tubule and has adversely effect on male fertility.

Download Full-text

Zearalenone impairs the male reproductive system functions via inducing structural and functional alterations of sertoli cells

Environmental Toxicology and Pharmacology ◽

10.1016/j.etap.2016.01.013 ◽

2016 ◽

Vol 42 ◽

pp. 146-155 ◽

Cited By ~ 28

Author(s):

WangLong Zheng ◽

ShunYe Pan ◽

Guangguang Wang ◽

Ya Jun Wang ◽

Qing Liu ◽

...

Keyword(s):

Sertoli Cells ◽

Reproductive System ◽

Male Reproductive System

Download Full-text

Reduced urea flux across the blood-testis barrier and early maturation in the male reproductive system in UT-B-null mice

AJP Cell Physiology ◽

10.1152/ajpcell.00608.2006 ◽

2007 ◽

Vol 293 (1) ◽

pp. C305-C312 ◽

Cited By ~ 20

Author(s):

Lirong Guo ◽

Dan Zhao ◽

Yuanlin Song ◽

Yan Meng ◽

Huashan Zhao ◽

...

Keyword(s):

Sertoli Cells ◽

Reproductive System ◽

Molecular Mechanisms ◽

Male Reproductive System ◽

Testis Weight ◽

Wild Type ◽

Early Puberty ◽

Early Maturation ◽

Androgen Binding

A urea-selective urine-concentrating defect was found in transgenic mice deficient in urea transporter (UT)-B. To determine the role of facilitated urea transport in extrarenal organs expressing UT-B, we studied the kinetics of [14C]urea distribution in UT-B-null mice versus wild-type mice. After renal blood flow was disrupted, [14C]urea distribution was selectively reduced in testis in UT-B-null mice. Under basal conditions, total testis urea content was 335.4 ± 43.8 μg in UT-B-null mice versus 196.3 ± 18.2 μg in wild-type mice ( P < 0.01). Testis weight in UT-B-null mice (6.6 ± 0.8 mg/g body wt) was significantly greater than in wild-type mice (4.2 ± 0.8 mg/g body wt). Elongated spermatids were observed earlier in UT-B-null mice compared with wild type mice on day 24 versus day 32, respectively. First breeding ages in UT-B knockout males (48 ± 3 days) were also significantly earlier than that in wild-type males (56 ± 2 days). In competing mating tests with wild-type males and UT-B-null males, all pups carried UT-B-targeted genes, which indicates that all pups were produced from breeding of UT-B-null males. Experiments of the expression of follicle-stimulating hormone receptor (FSHR) and androgen binding protein (ABP) indicated that the development of Sertoli cells was also earlier in UT-B-null mice than that in wild-type mice. These results suggest that UT-B plays an important role in eliminating urea produced by Sertoli cells and that UT-B deletion causes both urea accumulation in the testis and early maturation of the male reproductive system. The UT-B knockout mouse may be a useful experimental model to define the molecular mechanisms of early puberty.

Download Full-text