P.0148 Sex differences in first episode of psychosis with or without substance use history

2021 ◽  
Vol 53 ◽  
pp. S106-S107
Author(s):  
M. Garriga ◽  
S. Amoretti ◽  
G. Safont ◽  
N. Verdolini ◽  
G. Mezquida ◽  
...  
Keyword(s):  
Substance Use ◽  
Sex Differences ◽  
First Episode

No sex differences in neuropsychological performance in first episode psychosis patients

2014 ◽  
Vol 48 ◽  
pp. 149-154 ◽  
Author(s):  
Rosa Ayesa-Arriola ◽  
Jose Manuel Rodriguez-Sanchez ◽  
Elsa Gomez-Ruiz ◽  
Roberto Roiz-Santiáñez ◽  
Lauren L. Reeves ◽  
...  
Keyword(s):  
Sex Differences ◽  
First Episode Psychosis ◽  
First Episode ◽  
Neuropsychological Performance ◽  
Episode Psychosis

scholarly journals Sex Differences in First-Admission Psychiatric Inpatients With and Without a Comorbid Substance Use Disorder

2014 ◽  
Vol 8 (5) ◽  
pp. 351-358 ◽  
Author(s):  
Carla Gramaglia ◽  
Fabrizio Bert ◽  
Ada Lombardi ◽  
Alessandro Feggi ◽  
Marica Porro ◽  
...  
Keyword(s):  
Substance Use ◽  
Sex Differences ◽  
Substance Use Disorder ◽  
Psychiatric Inpatients ◽  
First Admission

scholarly journals Sensitive periods for the effect of childhood interpersonal violence on psychiatric disorder onset among adolescents

2017 ◽  
Vol 211 (6) ◽  
pp. 365-372 ◽  
Author(s):  
Erin C. Dunn ◽  
Yan Wang ◽  
Jenny Tse ◽  
Katie A. McLaughlin ◽  
Garrett Fitzmaurice ◽  
...  
Keyword(s):  
Substance Use ◽  
Psychiatric Disorder ◽  
Physical Abuse ◽  
Middle Childhood ◽  
Interpersonal Violence ◽  
Childhood Adversity ◽  
Elevated Risk ◽  
First Episode ◽  
Cross Sectional ◽  
Sensitive Periods

BackgroundAlthough childhood adversity is a strong determinant of psychopathology, it remains unclear whether there are ‘sensitive periods’ when a first episode of adversity is most harmful.AimsTo examine whether variation in the developmental timing of a first episode of interpersonal violence (up to age 18) associates with risk for psychopathology.MethodUsing cross-sectional data, we examined the association between age at first exposure to four types of interpersonal violence (physical abuse by parents, physical abuse by others, rape, and sexual assault/molestation) and onset of four classes of DSM-IV disorders (distress, fear, behaviour, substance use) (n=9984). Age at exposure was defined as: early childhood (ages 0–5), middle childhood (ages 6–10) and adolescence (ages 11–18).ResultsExposure to interpersonal violence at any age period about doubled the risk of a psychiatric disorder (odds ratios (ORs) = 1.51–2.52). However, few differences in risk were observed based on the timing of first exposure. After conducting 20 tests of association, only three significant differences in risk were observed based on the timing of exposure; these results suggested an elevated risk of behaviour disorder among youth first exposed to any type of interpersonal violence during adolescence (OR = 2.37, 95% CI 1.69–3.34), especially being beaten by another person (OR = 2.44; 95% CI 1.57–3.79), and an elevated risk of substance use disorder among youth beaten by someone during adolescence (OR=2.77, 95% CI 1.94–3.96).ConclusionsChildren exposed to interpersonal violence had an elevated risk of psychiatric disorder. However, age at first episode of exposure was largely unassociated with psychopathology risk.

scholarly journals Barriers and Facilitators That Influence Providers’ Ability to Educate, Monitor, and Treat Substance Use in First-Episode Psychosis Programs Using the Theoretical Domains Framework

2021 ◽  
pp. 104973232199344
Author(s):  
Oladunni Oluwoye ◽  
Elizabeth Fraser
Keyword(s):  
Substance Use ◽  
Behavior Change ◽  
Theoretical Domains Framework ◽  
First Episode Psychosis ◽  
Barriers And Facilitators ◽  
First Episode ◽  
Evidence Based ◽  
Behavior Change Techniques ◽  
Episode Psychosis ◽  
And Behavior

In this qualitative study, we explore providers’ experiences with addressing substance use among individuals with first-episode psychosis (FEP) enrolled in coordinated specialty care (CSC) programs. Three focus groups were conducted with 24 providers from CSC programs for FEP in Washington. Questions were focused on barriers and facilitators to addressing substance use using the Theoretical Domains Framework (TDF) as a guide. Thematic analysis was used to code all transcripts. Identified TDF domains were then mapped onto the COM-B (Capability, Opportunity, Motivation, Behavior) intervention functions and behavior change techniques. Seven theoretical domains were identified as the most relevant to addressing substance use: “Knowledge,” “Skills,” “Environmental Context and Resources,” “Social Influences,” “Social and Professional Role and Identity,” “Beliefs about Capabilities,” and “Reinforcement.” The use of the TDF provides a framework to explore barriers and facilitators for targeting substance use and suggestions for behavior change techniques when considering implementation of evidence-based strategies to enhance CSC models.

scholarly journals Introspective accuracy for substance use across a year of treatment for first episode psychosis

2021 ◽  
Vol 26 ◽  
pp. 100200
Author(s):  
Joshua E. Mervis ◽  
Jamie Fischer ◽  
Samuel E. Cooper ◽  
Andrew C. Deckert ◽  
Paul H. Lysaker ◽  
...  
Keyword(s):  
Substance Use ◽  
First Episode Psychosis ◽  
First Episode ◽  
Episode Psychosis

scholarly journals Sex Differences in Substance Use Disorders: A Neurobiological Perspective

2021 ◽  
Vol 2 ◽  
Author(s):  
Jennifer L. Cornish ◽  
Asheeta A. Prasad
Keyword(s):  
Substance Use ◽  
Sex Differences ◽  
Clinical Studies ◽  
Reward Processing ◽  
Future Research ◽  
Neural Structure ◽  
Patterns Of Use ◽  
Males And Females ◽  
Potential Impact ◽  
Advance Knowledge

Clinical studies provide fundamental knowledge of substance use behaviors (substance of abuse, patterns of use, relapse rates). The combination of neuroimaging approaches reveal correlation between substance use disorder (SUD) and changes in neural structure, function, and neurotransmission. Here, we review these advances, placing special emphasis on sex specific findings from structural neuroimaging studies of those dependent on alcohol, nicotine, cannabis, psychostimulants, or opioids. Recent clinical studies in SUD analyzing sex differences reveal neurobiological changes that are differentially impacted in common reward processing regions such as the striatum, hippocampus, amygdala, insula, and corpus collosum. We reflect on the contribution of sex hormones, period of drug use and abstinence, and the potential impact of these factors on the interpretation of the reported findings. With the overall recognition that SUD impacts the brains of females and males differentially, it is of fundamental importance that future research is designed with sex as a variable of study in this field. Improved understanding of neurobiological changes in males and females in SUD will advance knowledge underlying sex-specific susceptibility and the neurobiological impact in these disorders. Together these findings will inform future treatments that are tailor designed for improved efficacy in females and males with SUD.

scholarly journals S201. HIPPOCAMPAL SUBFIELD VOLUMES AND CHANGE IN BODY MASS OVER 12 MONTHS OF TREATMENT IN FIRST-EPISODE SCHIZOPHRENIA SPECTRUM DISORDERS

2020 ◽  
Vol 46 (Supplement_1) ◽  
pp. S114-S115
Author(s):  
Stéfan Du Plessis ◽  
Hilmar Luckhoff ◽  
Sanja Kilian ◽  
Laila Asmal ◽  
Frederika Scheffler ◽  
...  
Keyword(s):  
Substance Use ◽  
Weight Gain ◽  
Body Mass ◽  
Interactive Effect ◽  
First Episode ◽  
Schizophrenia Spectrum Disorders ◽  
Hippocampal Subfields ◽  
Schizophrenia Spectrum ◽  
Spectrum Disorders ◽  
First Episode Schizophrenia

Abstract Background In this study, we explored the relationship between hippocampal subfield volumes and change in body mass over 12 months of treatment in 90 first-episode schizophrenia spectrum disorder patients (66 males, 24 females; mean age= 24.7±6.8 years). Methods Body mass index was assessed in patients at baseline, and at months 3, 6, 9 and 12. Hippocampal subfields of interest were assessed using a segmentation algorithm included in the FreeSurfer 6.0 software program. Results Linear regression analysis showed a significant interactive effect between sex and anterior hippocampus size as a predictor of change in body mass over 12 months, adjusting for age, substance use, treatment duration, and posterior hippocampal volumes. In an exploratory sub-analysis, partial correlations revealed a significant association between weight gain and smaller CA1, CA3 and subiculum volumes in females, but not males, adjusting for age and substance use, with similar trends evident for the CA4 and presubiculum subfields. Discussion In conclusion, our findings suggest that smaller anterior hippocampal subfields are associated with the development of weight gain over the course of treatment in first-episode schizophrenia spectrum disorders in a sex-specific fashion, and may partly explain the more severe and ongoing increase in body mass evident for female patients.

scholarly journals Sex Differences in Diabetes Prevalence, Comorbidities, and Health Care Utilization among American Indians Living in the Northern Plains

2019 ◽  
Vol 4 (Supplement_1) ◽  
pp. 42-48 ◽  
Author(s):  
Kimberly R Huyser ◽  
Jennifer Rockell ◽  
Valarie Blue Bird Jernigan ◽  
Tori Taniguchi ◽  
Charlton Wilson ◽  
...  
Keyword(s):  
Mental Health ◽  
Health Care ◽  
Substance Use ◽  
Sex Differences ◽  
Health Care Utilization ◽  
Care Utilization ◽  
Northern Plains ◽  
Men And Women ◽  
Service Unit ◽  
Adult Men

ABSTRACT Background The American Indian (AI) population experiences significant diet-related health disparities including diabetes and cardiovascular disease (CVD). Owing to the relatively small sample size of AIs, the population is rarely included in large national surveys such as the NHANES. This exclusion hinders efforts to characterize potentially important differences between AI men and women, track the costs of these disparities, and effectively treat and prevent these conditions. Objective We examined the sex differences in diabetes prevalence, comorbidity experience, health care utilization, and treatment costs among AIs within a Northern Plains Indian Health Service (IHS) service unit. Methods We assessed data from a sample of 11,144 persons using an IHS service unit in the Northern Plains region of the United States. Detailed analyses were conducted for adults (n = 7299) on prevalence of diabetes by age and sex. We described sex differences in comorbidities, health care utilization, and treatment costs among the adults with diabetes. Results In our sample, adult men and women had a similar prevalence of diabetes (10.0% and 11.0%, respectively). The prevalence of CVD among men and women with diabetes was 45.7% and 34.0%, respectively. Among adults with diabetes, men had a statistically higher prevalence of hypertension and substance use disorders than women. The men were statistically less likely to have a non–substance use mental health disorder. Although men had higher utilization and costs for hospital inpatient services than women, the differences were not statistically significant. Conclusions In this AI population, there were differences in comorbidity profiles between adult men and women with diabetes, which have differential mortality and cost consequences. Appropriate diabetes management addressing gender-specific comorbidities, such as substance use disorders for men and non–substance use mental health disorders for women, may help reduce additional comorbidities or complications to diabetes.

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