Lower availability of midbrain serotonin transporter between healthy subjects with and without a family history of major depressive disorder – a preliminary two-ligand SPECT study

2014 ◽  
Vol 29 (7) ◽  
pp. 414-418 ◽  
Author(s):  
P.C. Hsieh ◽  
K.C. Chen ◽  
T.L. Yeh ◽  
I.H. Lee ◽  
P.S. Chen ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Family History ◽  
Depressive Disorder ◽  
Serotonin Transporter ◽  
Healthy Subjects ◽  
Healthy Controls ◽  
Major Depressive ◽  
Dopaminergic Dysfunction ◽  
History Of ◽  
Family History Of Depression

AbstractPurposeSerotonin transporter (SERT) and dopamine transporter (DAT) levels differ in patients with major depressive disorder (MDD) who are in a depressed state in comparison with healthy controls. In addition, a family history of depression is a potent risk factor for developing depression, and inherited vulnerability to serotonergic and dopaminergic dysfunction is suspected in this. The aim of this study was to examine the availabilities of midbrain SERT and striatal DAT in healthy subjects with and without a first-degree family history of MDD.MethodsEight healthy subjects with first-degree relatives with MDD and 16 sex- and age-matched healthy controls were recruited. The availabilities of SERT and DAT were approximated using SPECT, employing [123I] 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM) and [99mTc] TRODAT-1 as the ligands, respectively. There are missing data for one participant with a first-degree family history of MDD from the ADAM study, due to a lack of the radio-ligand at the time of experiment.ResultsSERT availability in the midbrain was significantly lower in subjects with a first-degree family history of MDD than in healthy subjects. However, DAT availability was no different between two groups.ConclusionsThe results with regard to the midbrain SERT level suggest the heritability of MDD.

scholarly journals Lymphocyte subsets and their association with the severity of patients with major depressive disorder (mdd)

2019 ◽  
Vol 3 (2) ◽  
pp. 80
Author(s):  
Noor Suryani Mohd Ashari ◽  
Siti Nor Fairus Mohamed Sanusi ◽  
Mohd Azhar Mohd Yasin ◽  
Rohimah Mohamud ◽  
Che Maraina Che Hussin
Keyword(s):  
Major Depressive Disorder ◽  
Family History ◽  
Depressive Disorder ◽  
Rural Area ◽  
Healthy Controls ◽  
Major Depressive ◽  
Chi Square ◽  
History Of ◽  
Family History Of Depression ◽  
History Of Depression

Introduction: Major Depressive Disorder (MDD) isexpected to become the second leading cause of worldwide disability by the year 2020 and the major contributor to the overall global burden of disease.Objective: This study was done to compare sociodemographicpredisposingfactors in MDD patients and controls in Kelantan, Malaysia.Methods: A total of 47 MDD patients and 47 healthy controls participated in this study. MDD patients were recruited from Psychiatric Clinic, HUSM and they were diagnosed according to DSM-V criteria. Patients’ biodata, medical and psychiatric history were taken by physician. Data were analysed using Pearson Chi-square and multiple logistic regression.Results: In MDD group, 61.7% were females and 38.3% were males. Forty two percent of MDD were in the age group of 45 to 65 years old and almost 12.8% of MDD patients had family history of depression, while all healthy controls were in good general health and had no family history of depression. Pearson Chi-square revealed that there were significant associations between smoking status (P=0.027), marital status (P=0.007) educational level (P=0.022) and area of living (P=0.0.036) with MDD. The results showed that unmarried person were less likely to have MDD compared to those married with adjusted odds ratio (OR) of 0.31. Smoker were 5.16 at odds of having MDD as compared to non-smoker, while individuals with a low education were more likely to have MDD compared to those highly educated with adjusted OR of 2.04. The result also showed those living in urban area were less likely to have MDD compared to those living in rural area with adjusted OR of 0.48.Conclusion: Higher age, female and positive family history possess a higher tendency of having MDD. In addition, smokers, married, less educated and living in rural area were more likely to have MDD compared to healthy controls.International Journal of Human and Health Sciences Vol. 03 No. 02 April’19. Page: 80-87

scholarly journals Family history of mood disorder and characteristics of major depressive disorder: A STAR∗D (sequenced treatment alternatives to relieve depression) study

2007 ◽  
Vol 41 (3-4) ◽  
pp. 214-221 ◽  
Author(s):  
Andrew A. Nierenberg ◽  
Madhukar H. Trivedi ◽  
Maurizio Fava ◽  
Melanie M. Biggs ◽  
Kathy Shores-Wilson ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Family History ◽  
Depressive Disorder ◽  
Mood Disorder ◽  
Major Depressive ◽  
History Of ◽  
Treatment Alternatives

Hippocampal volume and serotonin transporter polymorphism in major depressive disorder

2013 ◽  
Vol 25 (4) ◽  
pp. 206-214 ◽  
Author(s):  
Jamila Ahdidan ◽  
Leslie Foldager ◽  
Raben Rosenberg ◽  
Anders Rodell ◽  
Poul Videbech ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Serotonin Transporter ◽  
Brain Volume ◽  
Hippocampal Volume ◽  
Healthy Controls ◽  
Major Depressive ◽  
Total Brain Volume ◽  
Total Brain ◽  
Serotonin Transporter Polymorphism

ObjectiveThe main aim of the present study was to replicate a previous finding in major depressive disorder (MDD) of association between reduced hippocampal volume and the long variant of the di- and triallelic serotonin transporter polymorphism inSLC6A4on chromosome 17q11.2. Secondarily, we also hypothesised that 5-HTTLPR may be a risk factor for MDD.MethodsQuantitative magnetic resonance imaging (MRI) of the hippocampus was studied in 23 inpatients suffering from MDD and in 33 healthy controls. Normalised volumetric MRI data of hippocampus were assessed with adjustment for total brain volume and tensor-based morphometry was used to elucidate structural brain differences. A triallelic genetic marker resulting from twoSLC6A4promoter region polymorphisms, 5-HTTLPR and rs25531, was analysed for association with MDD and quantitative traits.ResultsHealthy controls had a smaller relative hippocampal volume (relative to brain size) but a larger total brain volume compared with patients with MDD. For patients compared with healthy controls, atrophy was found in the right temporal lobe and pons medulla. Allele and genotype frequencies were strikingly different from the previous study that we aimed to replicate, and no significant associations with the serotonin transporter polymorphism were found.ConclusionsThe present quantitative and morphometric MRI study was not able to replicate the previous finding of association between reduced hippocampal volume in depressed patients and the serotonin transporter polymorphism.

Family history of psychiatric disorders and the outcome of psychiatric patients with DSM-IV major depressive disorder

2011 ◽  
Vol 131 (1-3) ◽  
pp. 251-259 ◽  
Author(s):  
K. Mikael Holma ◽  
Tarja K. Melartin ◽  
Irina A.K. Holma ◽  
Tiina Paunio ◽  
Erkki T. Isometsä
Keyword(s):  
Major Depressive Disorder ◽  
Family History ◽  
Depressive Disorder ◽  
Psychiatric Disorders ◽  
Psychiatric Patients ◽  
Major Depressive ◽  
History Of ◽  
Dsm Iv

scholarly journals Disruptive mood dysregulation disorder in offspring of parents with depression and bipolar disorder

2017 ◽  
Vol 210 (6) ◽  
pp. 408-412 ◽  
Author(s):  
Lukas Propper ◽  
Jill Cumby ◽  
Victoria C. Patterson ◽  
Vladislav Drobinin ◽  
Jacqueline M. Glover ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Major Depressive Disorder ◽  
Family History ◽  
Depressive Disorder ◽  
Control Group ◽  
Major Depressive ◽  
Disruptive Mood Dysregulation Disorder ◽  
Increased Risk ◽  
History Of ◽  
Mood Dysregulation

BackgroundIt has been suggested that offspring of parents with bipolar disorder are at increased risk for disruptive mood dysregulation disorder (DMDD), but the specificity of this association has not been established.AimsWe examined the specificity of DMDD to family history by comparing offspring of parents with (a) bipolar disorder, (b) major depressive disorder and (c) a control group with no mood disorders.MethodWe established lifetime diagnosis of DMDD using the Schedule for Affective Disorders and Schizophrenia for School Aged Children for DSM-5 in 180 youth aged 6–18 years, including 58 offspring of parents with bipolar disorder, 82 offspring of parents with major depressive disorder and 40 control offspring.ResultsDiagnostic criteria for DMDD were met in none of the offspring of parents with bipolar disorder, 6 of the offspring of parents with major depressive disorder and none of the control offspring. DMDD diagnosis was significantly associated with family history of major depressive disorder.ConclusionsOur results suggest that DMDD is not specifically associated with a family history of bipolar disorder and may be associated with parental depression.

scholarly journals Joint Effect of Childhood Abuse and Family History of Major Depressive Disorder on Rates of PTSD in People with Personality Disorders

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Janine D. Flory ◽  
Rachel Yehuda ◽  
Vincent Passarelli ◽  
Larry J. Siever
Keyword(s):  
Major Depressive Disorder ◽  
Family History ◽  
Depressive Disorder ◽  
Childhood Abuse ◽  
Childhood Maltreatment ◽  
Reference Group ◽  
Joint Effect ◽  
Major Depressive ◽  
Increased Risk ◽  
History Of

Objective. Childhood maltreatment and familial psychopathology both lead to an increased risk of the development of posttraumatic stress disorder (PTSD) in adulthood. While family history of psychopathology has traditionally been viewed as a proxy for genetic predisposition, such pathology can also contribute to a stress-laden environment for the child.Method. Analyses were conducted to evaluate the joint effect of childhood abuse and a family history of major depressive disorder (MDD) on diagnoses of PTSD and MDD in a sample of 225 adults with DSM-IV Axis II disorders.Results.Results showed that the rate of PTSD in the presence of both childhood abuse and MDD family history was almost six-fold (OR=5.89,  P=.001) higher relative to the absence of both factors. In contrast, the rate of MDD in the presence of both factors was associated with a nearly three-fold risk relative to the reference group (OR=2.75,  P=.01).Conclusions. The results from this observational study contribute to a growing understanding of predisposing factors for the development of PTSD and suggest that joint effects of family history of MDD and childhood abuse on PTSD are greater than either factor alone.

Major depressive disorder and family history of alcoholism in two treatment samples: Does gender matter?

2017 ◽  
Vol 171 ◽  
pp. e167
Author(s):  
Kathryn McKenzie Polak ◽  
Alexis Edwards ◽  
Kenneth S. Kendler ◽  
Dace Svikis ◽  
Enkelejda Ngjelina ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Family History ◽  
Depressive Disorder ◽  
Major Depressive ◽  
History Of

Emotional processing and executive functions in major depressive disorder: dorsal prefrontal activity correlates with performance in the intra–extra dimensional set shift

2010 ◽  
Vol 22 (6) ◽  
pp. 269-279 ◽  
Author(s):  
Alexander Heinzel ◽  
Georg Northoff ◽  
Heinz Boeker ◽  
Peter Boesiger ◽  
Simone Grimm
Keyword(s):  
Major Depressive Disorder ◽  
Prefrontal Cortex ◽  
Depressive Disorder ◽  
Executive Functions ◽  
Healthy Subjects ◽  
Emotional Processing ◽  
Cognitive Impairments ◽  
Healthy Controls ◽  
Major Depressive ◽  
The Right

Heinzel A, Northoff G, Boeker H, Boesiger P, Grimm S. Emotional processing and executive functions in major depressive disorder: dorsal prefrontal activity correlates with performance in the intra–extra dimensional set shift.Objective:Major depressive disorder (MDD) is characterised by predominately negatively valenced emotional symptoms that are often accompanied by cognitive impairments. We posited that cognitive impairments in MDD are related to altered emotional processing in prefrontal cortex.Methods:We compared 20 medication-free patients with MDD and 29 matched healthy controls. Both groups performed an emotional task during functional magnetic resonance imaging (fMRI). Furthermore, they completed the intra–extra dimensional set shift (IED) test probing for cognitive impairments. Then we correlated the results of the IED with the changes in fMRI BOLD signal in MDD patients and healthy subjects.Results:The subcategory of the IED applying extradimensional shift (EDS) showed a divergent performance of the MDD group committing significantly more errors than the control group. Correlating the EDS errors with fMRI signal changes, the healthy subjects showed a positive correlation with the right ventrolateral prefrontal cortex and the right orbitofrontal cortex. MDD subjects, in contrast, showed a positive correlation in right dorsolateral prefrontal cortex (DLPFC) and a negative correlation in the left dorsomedial prefrontal cortex (DMPFC).Conclusion:We hypothesise that the differential correlation in healthy controls and MDD patients may reflect the use of different strategies in their performance. The impaired executive functions, as reflected by altered processing in right DLPFC and left DMPFC, may implicitly influence emotional processing in patients suffering from MDD.

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