Impact of a type-D personality on clinical and psychometric properties of patients with a first myocardial infarction in a Turkish sample

ObjectiveRecent studies have shown that a Type D personality is associated with an increased risk of cardiac mortality. This study aimed to examine impact of a Type D personality on clinical and psychometric properties of patients with a first myocardial infarction (MI) in a Turkish sample.MethodThe study included 131 patients who were admitted to the coronary care unit of a hospital with a first MI. All the patients underwent a psychiatric assessment within 2–6 months post-MI. Psychiatric interviews were conducted with the Structured Clinical Interview for DSM-IV (SCID-I).ResultsThe first study group (Type D personality) included 50 patients, and the second study group (non-Type D personality) included 81 patients. There was a 38.2% prevalence of the Type D personality in the patients with a first MI. Those with this type of personality had a significantly higher frequency of hypertension and stressful life events. The Type D patients also had more psychiatric disorders, depressive disorders, and anxiety disorders than the non-Type D patients.ConclusionsOur findings suggest that Type D personality traits may increase the risk of hypertension and the risk of psychiatric morbidity in patients with a first MI. Considering that a Type D personality is a stable trait; we suggest that this type of personality is a facilitator of clinical depression and anxiety disorders. These findings emphasize the importance of screening for a Type D personality as a cardiovascular risk marker and a psychiatric risk marker in MI patients.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Impact of a Type D Personality on Clinical and Psychometric Properties in a Sample of Turkish Patients With a First Myocardial Infarction

Journal of Psychiatric Practice ◽

10.1097/pra.0000000000000201 ◽

2017 ◽

Vol 23 (1) ◽

pp. 3-10 ◽

Cited By ~ 2

Author(s):

BILGE B. ANNAGÜR ◽

KENAN DEMIR ◽

AHMET AVCI ◽

ÖMER FARUK UYGUR

Keyword(s):

Myocardial Infarction ◽

Psychometric Properties ◽

Type D Personality ◽

Type D ◽

Turkish Patients ◽

First Myocardial Infarction

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The combined impact of Type D personality and depression on cardiovascular events after acute myocardial infarction

Psychological Medicine ◽

10.1017/s0033291721002932 ◽

2021 ◽

pp. 1-11

Author(s):

Yini Wang ◽

Xueqin Gao ◽

Zhenjuan Zhao ◽

Ling Li ◽

Guojie Liu ◽

...

Keyword(s):

Risk Factors ◽

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Significant Risk ◽

Type D Personality ◽

Adverse Outcomes ◽

Combined Effect ◽

Continuous Variables ◽

Type D

Abstract Background Type D personality and depression are the independent psychological risk factors for adverse outcomes in cardiovascular patients. The aim of this study was to examine the combined effect of Type D personality and depression on clinical outcomes in patients suffering from acute myocardial infarction (AMI). Methods This prospective cohort study included 3568 patients diagnosed with AMI between February 2017 and September 2018. Type D personality and depression were assessed at baseline, while the major adverse cardiac event (MACE) rate (cardiac death, recurrent non-fatal myocardial infarction, revascularization, and stroke) and in-stent restenosis (ISR) rate were analyzed after a 2-year follow-up period. Results A total of 437 patients developed MACEs and 185 had ISR during the follow-up period. The Type D (+) depression (+) and Type D (+) depression (−) groups had a higher risk of MACE [95% confidence interval (CI) 1.74–6.07] (95% CI 1.25–2.96) and ISR (95% CI 3.09–8.28) (95% CI 1.85–6.22). Analysis of Type D and depression as continuous variables indicated that the main effect of Type D, depression and their combined effect were significantly associated with MACE and ISR. Moreover, Type D (+) depression (+) and Type D (+) depression (−) emerged as significant risk factors for MACE and ISR in males, while only Type D (+) depression (+) was associated with MACE and ISR in female patients. Conclusions These findings suggest that patients complicated with depression and Type D personality are at a higher risk of adverse cardiovascular outcomes. Individual assessments of Type D personality and depression, and comprehensive interventions are required.

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The Heritability of Type D Personality by an Extended Twin-Pedigree Analysis in the Netherlands Twin Register

Behavior Genetics ◽

10.1007/s10519-020-10023-x ◽

2020 ◽

Author(s):

Ruifang Li-Gao ◽

Dorret I. Boomsma ◽

Eco J. C. de Geus ◽

Johan Denollet ◽

Nina Kupper

Keyword(s):

The Netherlands ◽

Variance Components ◽

Genetic Model ◽

Additive Genetic Variance ◽

Type D Personality ◽

Continuous Measure ◽

Genetic Covariance ◽

Type D ◽

Genetic Components ◽

Increased Risk

Abstract Type D (Distressed) personality combines negative affectivity (NA) and social inhibition (SI) and is associated with an increased risk of cardiovascular disease. We aimed to (1) validate a new proxy based on the Achenbach System of Empirically Based Assessment (ASEBA) for Type D personality and its NA and SI subcomponents and (2) estimate the heritability of the Type D proxy in an extended twin-pedigree design in the Netherlands Twin Register (NTR). Proxies for the dichotomous Type D classification, and continuous NA, SI, and NAxSI (the continuous measure of Type D) scales were created based on 12 ASEBA items for 30,433 NTR participants (16,449 twins and 13,984 relatives from 11,106 pedigrees) and sources of variation were analyzed in the ‘Mendel’ software package. We estimated additive and non-additive genetic variance components, shared household and unique environmental variance components and ran bivariate models to estimate the genetic and non-genetic covariance between NA and SI. The Type D proxy showed good reliability and construct validity. The best fitting genetic model included additive and non-additive genetic effects with broad-sense heritabilities for NA, SI and NAxSI estimated at 49%, 50% and 49%, respectively. Household effects showed small contributions (4–9%) to the total phenotypic variation. The genetic correlation between NA and SI was .66 (reflecting both additive and non-additive genetic components). Thus, Type D personality and its NA and SI subcomponents are heritable, with a shared genetic basis for the two subcomponents.

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The HR2 Haplotype of Factor V Is not Associated with the Risk of Myocardial Infarction

Thrombosis and Haemostasis ◽

10.1055/s-0037-1614122 ◽

2000 ◽

Vol 84 (11) ◽

pp. 815-818 ◽

Cited By ~ 8

Author(s):

Carine Doggen ◽

Marieke de Visser ◽

Hans Vos ◽

Rogier Bertina ◽

Volkert Cats ◽

...

Keyword(s):

Myocardial Infarction ◽

Factor V Leiden ◽

Myocardial Infarctions ◽

Control Group ◽

Factor V ◽

Increased Risk ◽

Factor V Gene ◽

Heterozygous Carriers ◽

First Myocardial Infarction ◽

Control Study

SummaryThe HR2 haplotype of the factor V gene, which contains the histidine to arginine substitution at position 1299, has been reported to be associated with reduced factor V levels. Because high factor V levels have been found to be associated with an increased risk of myocardial infarction, we examined how the presence of the R2 allele affected the risk of myocardial infarction in the case-control “Study of Myocardial Infarctions Leiden”.Among 560 men with a first myocardial infarction before the age of 70 years, 9.5% were heterozygous carriers of the R2 allele. The control group consisted of 646 men, in which 9.9% were heterozygous and 0.2% homozygous carriers of the R2 allele. The risk of myocardial infarction in the presence of the R2 allele was not increased (odds ratio, 0.9; 95% confidence interval 0.6 to 1.4). Exclusion of factor V Leiden carriers did not change this result. The risk was 4.4-fold increased for smokers who carried the R2 allele compared to non-smoking noncarriers. No synergy was found between metabolic risk factors and the presence of the R2 allele.We conclude that the risk of myocardial infarction for men in the presence of the R2 allele of the His1299Arg polymorphism is neither increased nor decreased.

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Type D Personality and Myocardial Infarction: A Case-Control Study

Indian Journal of Psychological Medicine ◽

10.1177/0253717620947157 ◽

2020 ◽

pp. 025371762094715

Author(s):

MT Manoj ◽

KA Joseph ◽

Govindan Vijayaraghavan

Keyword(s):

Myocardial Infarction ◽

Case Control Study ◽

Tertiary Care ◽

Multivariate Logistic Regression Analysis ◽

Developed Countries ◽

Case Control ◽

Type D Personality ◽

Care Hospital ◽

Type D ◽

Control Study

Background: Coronary heart disease (CHD) is an impending global pandemic in developed countries as well as developing countries and economies in transition, such as India. A significant increase in the incidence of myocardial infarction (MI), one of the most common types of CHD, is being reported in India, and the incidence and severity of the disease are more among the youth in Kerala. Studies assessing the association between psychological factors and MI are few in India. Methods: We adopted a case-control study design. A total of 150 cases (with MI) and 150 controls (without MI and matched for age and gender) from a tertiary care hospital in Trivandrum, Kerala, India, were selected using convenient sampling method, between September 2016 and August 2017. Results: As compared to 33.3% of the controls, 50.7% of patients with MI had type D personality characteristics. Multivariate logistic regression analysis after adjusting for the confounders indicated a positive and statistically significant association between type D personality and MI: OR = 4.14, 95% CI = 2.19–8.85, P = 0.003. Conclusion: Type D personality is associated with MI.

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