Assessment of epoxidized soy bean oil (ESBO) migrating into foods: Comparison with ESBO-like epoxy fatty acids in our normal diet

2006 ◽  
Vol 44 (8) ◽  
pp. 1279-1286 ◽  
Author(s):  
Anja Fankhauser-Noti ◽  
Katell Fiselier ◽  
Sandra Biedermann-Brem ◽  
Koni Grob
Keyword(s):  
Fatty Acids ◽  
Normal Diet ◽  
Epoxy Fatty Acids ◽  
Soy Bean Oil

scholarly journals Glycerol Monocaprylate Modulates Gut Microbiota and Increases Short-Chain Fatty Acids Production without Adverse Effects on Metabolism and Inflammation

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1427
Author(s):  
Junhui Zhang ◽  
Fengqin Feng ◽  
Minjie Zhao
Keyword(s):  
Fatty Acids ◽  
Gut Microbiota ◽  
Dose Group ◽  
Low Dose ◽  
Short Chain Fatty Acids ◽  
Normal Diet ◽  
Short Chain ◽  
High Dose ◽  
Dose Treatment ◽  
Chain Fatty Acids

Glycerol monocaprylate (GMC) is a glycerol derivative of medium-chain fatty acids (MCFAs) and is widely used as a preservative in food processing. However, GMC and its hydrolytic acid (octylic acid) have antibacterial properties that may affect the physiology and intestinal microecology of the human body. Therefore, in this study, the effects of two different dosages of GMC (150 and 1600 mg kg−1) on glucose, lipid metabolism, inflammation, and intestinal microecology of normal diet-fed C57BL/6 mice were comprehensively investigated. The obtained results showed that the level of triglycerides (TGs) in the low-dose group down-regulated significantly, and the anti-inflammatory cytokine interleukin 10 (IL-10) significantly increased, while the pro-inflammatory cytokines monocyte chemotactic protein 1 (MCP-1) and interleukin 1beta (IL-1β) in the high-dose group were significantly decreased. Importantly, GMC promoted the α-diversity of gut microbiota in normal-diet-fed mice, regardless of dosages. Additionally, it was found that the low-dose treatment of GMC significantly increased the abundance of Lactobacillus, while the high-dose treatment of GMC significantly increased the abundance of SCFA-producers such as Clostridiales, Lachnospiraceae, and Ruminococcus. Moreover, the content of short-chain fatty acids (SCFAs) was significantly increased by GMC supplementation. Thus, our research provides a novel insight into the effects of GMC on gut microbiota and physiological characteristics.

Occurrence of Keto, Hydroxy and Epoxy Fatty Acids in Argemone mexicana Seed Oil

1972 ◽  
Vol 74 (5) ◽  
pp. 268-270 ◽  
Author(s):  
V. V. S. Mani ◽  
Gollamudi Lakshminarayana
Keyword(s):  
Fatty Acids ◽  
Seed Oil ◽  
Argemone Mexicana ◽  
Epoxy Fatty Acids

Dietary epoxy fatty acids are absorbed in healthy women

2002 ◽  
Vol 32 (2) ◽  
pp. 79-83 ◽  
Author(s):  
R. Wilson ◽  
C. E. Fernie ◽  
C. M. Scrimgeour ◽  
K. Lyall ◽  
L. Smyth ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Healthy Women ◽  
Epoxy Fatty Acids

scholarly journals Epoxy fatty acids mediate analgesia in murine diabetic neuropathy

2016 ◽  
Vol 21 (3) ◽  
pp. 456-465 ◽  
Author(s):  
K. Wagner ◽  
K.S.S. Lee ◽  
J. Yang ◽  
B.D. Hammock
Keyword(s):  
Fatty Acids ◽  
Diabetic Neuropathy ◽  
Epoxy Fatty Acids

scholarly journals Epoxide hydrolase activities and epoxy fatty acids in the mosquito Culex quinquefasciatus

2015 ◽  
Vol 59 ◽  
pp. 41-49 ◽  
Author(s):  
Jiawen Xu ◽  
Christophe Morisseau ◽  
Jun Yang ◽  
Dadala M. Mamatha ◽  
Bruce D. Hammock
Keyword(s):  
Fatty Acids ◽  
Culex Quinquefasciatus ◽  
Epoxide Hydrolase ◽  
Epoxy Fatty Acids

scholarly journals Epoxy Fatty Acids: From Salt Regulation to Kidney and Cardiovascular Therapeutics

Hypertension ◽  
2020 ◽  
Vol 76 (1) ◽  
pp. 3-15
Author(s):  
John D. Imig ◽  
Wojciech K. Jankiewicz ◽  
Abdul H. Khan
Keyword(s):  
Fatty Acids ◽  
Resistance Arteries ◽  
Therapeutic Approaches ◽  
High Salt Diet ◽  
Salt Diet ◽  
Protective Actions ◽  
Epoxy Fatty Acids ◽  
Soluble Epoxide Hydrolase Inhibitors ◽  
Cardiovascular Therapeutics ◽  
Salt Sensitive Hypertension

Epoxyeicosatrienoic acids (EETs) are epoxy fatty acids that have biological actions that are essential for maintaining water and electrolyte homeostasis. An inability to increase EETs in response to a high-salt diet results in salt-sensitive hypertension. Vasodilation, inhibition of epithelial sodium channel, and inhibition of inflammation are the major EET actions that are beneficial to the heart, resistance arteries, and kidneys. Genetic and pharmacological means to elevate EETs demonstrated antihypertensive, anti-inflammatory, and organ protective actions. Therapeutic approaches to increase EETs were then developed for cardiovascular diseases. sEH (soluble epoxide hydrolase) inhibitors were developed and progressed to clinical trials for hypertension, diabetes mellitus, and other diseases. EET analogs were another therapeutic approach taken and these drugs are entering the early phases of clinical development. Even with the promise for these therapeutic approaches, there are still several challenges, unexplored areas, and opportunities for epoxy fatty acids.

scholarly journals Levels of polyunsaturated fatty acids in lymphocytes of rats fed on diets varying in polyunsaturated fatty acid content

1980 ◽  
Vol 43 (2) ◽  
pp. 367-373 ◽  
Author(s):  
W. M. Tsagn ◽  
J. Belin ◽  
A. D. Smith
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Polyunsaturated Fatty Acid ◽  
Fatty Acid Content ◽  
Inverse Correlation ◽  
Normal Diet ◽  
Deficient Diet ◽  
Polyunsaturated Fatty Acid Content ◽  
Weanling Rats ◽  
Total Fatty Acids

1. When weanling rats were fed on a diet containing 0.1 g/kg of the diet as polyunsaturated fatty acid, it was found that after 2 weeks the level of linoleate in the lymphocyte total lipids was 56 mg/ g total fatty acids, as compared with a level of 138 mg/ g in rats on a normal diet (P < 0.005). Similar levels were obtained from rats which had been fed for up to 16 weeks on the deficient diet, but in a group killed after 28 weeks on the diet the level was found to be only 20 mg/ g total fatty acids. The arachidonate level was found to be approximately 220 mg/ g total fatty acids, regardless of whether the rats were fed on a diet deficient in linoleate for up to 16 weeks or on a normal diet. In the group of rats killed after 28 weeks on the linoleate deficient diet, however, the arachidonate level was only 60 mg/ g total fatty acids.2. Percentage values for total fatty acids are given for plasma, adipose tissue, and lymphocytes for rats on normal and experimental diets.3. Scatter diagrams of the levels of linoleate v. arachidonate in the lymphocyte total fatty acids showed no correlation between the levels of the two acids (r 0.05), but similar plots of linoleate and oleate levels showed an inverse correlation (r – 0.68).

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