Protective effect of olive leaves phenolic compounds against neurodegenerative disorders: Promising alternative for Alzheimer and Parkinson diseases modulation

2021 ◽  
pp. 112752
Author(s):  
Fatma Hadrich ◽  
Mohamed Chamkha ◽  
Sami Sayadi
Keyword(s):  
Phenolic Compounds ◽  
Protective Effect ◽  
Neurodegenerative Disorders ◽  
Olive Leaves ◽  
Promising Alternative ◽  
Parkinson Diseases

scholarly journals Wine Polyphenols: Potential Agents in Neuroprotection

2012 ◽  
Vol 2012 ◽  
pp. 1-14 ◽  
Author(s):  
Abdelkader Basli ◽  
Stéphanie Soulet ◽  
Nassima Chaher ◽  
Jean-Michel Mérillon ◽  
Mohamed Chibane ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Phenolic Compounds ◽  
Protective Effect ◽  
Neurodegenerative Disorders ◽  
Red Wine ◽  
Antioxidant Properties ◽  
Polyphenolic Compounds ◽  
Neuroprotective Effects ◽  
Wine Polyphenols

There are numerous studies indicating that a moderate consumption of red wine provides certain health benefits, such as the protection against neurodegenerative diseases. This protective effect is most likely due to the presence of phenolic compounds in wine. Wine polyphenolic compounds are well known for the antioxidant properties. Oxidative stress is involved in many forms of cellular and molecular deterioration. This damage can lead to cell death and various neurodegenerative disorders, such as Parkinson’s or Alzheimer’s diseases. Extensive investigations have been undertaken to determine the neuroprotective effects of wine-related polyphenols. In this review we present the neuroprotective abilities of the major classes of wine-related polyphenols.

Evaluation of the protective effect of chemical additives in the oxidation of phenolic compounds catalysed by peroxidase

2015 ◽  
Vol 37 (10) ◽  
pp. 1288-1295 ◽  
Author(s):  
Juliana Arriel Torres ◽  
Pricila Maria Batista Chagas ◽  
Maria Cristina Silva ◽  
Custódio Donizete dos Santos ◽  
Angelita Duarte Corrêa
Keyword(s):  
Phenolic Compounds ◽  
Protective Effect ◽  
Chemical Additives

Programmed cell death in plants: Protective effect of phenolic compounds against chitosan and H2O2

2010 ◽  
Vol 75 (2) ◽  
pp. 257-263 ◽  
Author(s):  
V. D. Samuilov ◽  
L. A. Vasil’ev ◽  
E. V. Dzyubinskaya ◽  
D. B. Kiselevsky ◽  
A. V. Nesov
Keyword(s):  
Cell Death ◽  
Phenolic Compounds ◽  
Programmed Cell Death ◽  
Protective Effect

scholarly journals Comparative Evaluation of Argania spinosa and Olea europaea Leaf Phenolic Compounds and their Antioxidant Activity

Botanica ◽  
2020 ◽  
Vol 26 (1) ◽  
pp. 76-87
Author(s):  
Aziza Lfitat ◽  
Hind Zejli ◽  
Abdelkamel Bousselham ◽  
Yassine El Atki ◽  
Badiaa Lyoussi ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Phenolic Compounds ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Total Phenolic ◽  
Olive Leaves ◽  
Antioxidant Power ◽  
Ferric Reducing Antioxidant Power ◽  
Total Flavonoids Content

AbstractWe conducted this study to determine and compare the content of phenolic compounds and flavonoids in the argan and olive leaves as well as their antioxidant capacity in aqueous, methanolic, and ethyl acetate extracted fractions. In vitro antioxidant activity was evaluated in comparison with synthetic antioxidants by assessing DPPH• radical scavenging capacity, ferric reducing antioxidant power, scavenging ability by inhibiting the β-carotene/linoleic acid emulsion oxidation, and by the ABTS radical scavenging activity assay. Total phenolic content in argan samples ranged from 221.69 ± 2.07 to 1.32 ± 0.01 mg GAE/g DW and in olive samples from 144.61 ± 0.82 to 1.21 ± 0.02 mg GAE/g DW. Total flavonoids content in argan samples varied from 267.37 ± 1.12 to 25.48 ± 0.02 mg QE/g DW, while in olives from 96.06 ± 0.78 to 10.63 ± 0.05 mg QE/g DW. In vitro antioxidant studies strongly confirmed the antioxidant potency of argan and olive leaves and their richness in secondary metabolites that are effective in free radicals scavenging and metal chelating capacities, indicating their antioxidant power.

Isolation of hydroxytyrosol from olive leaves extract, radioiodination and investigation of bioaffinity using in vivo/in vitro methods

2013 ◽  
Vol 101 (9) ◽  
pp. 585-593 ◽  
Author(s):  
M. Ozkan ◽  
F. Z. Biber Muftuler ◽  
A. Yurt Kilcar ◽  
E. I. Medine ◽  
P. Unak
Keyword(s):  
Small Intestine ◽  
Phenolic Compounds ◽  
Biological Activities ◽  
In Vivo Studies ◽  
Flavonoid Content ◽  
Olive Leaves ◽  
In Vitro Methods ◽  
Extraction And Purification

Summary It is known that medicinal plants like olive have biological activities due to their flavonoid content such as olueropein, tyrosol, hydroxytyrosol etc. In current study, hydroxytrosol (HT) which is one of the major phenolic compounds in olive, olive leaves and olive oil, was isolated after methanol extraction and purification of olive leaves which are grown in the northern Anatolia region of Turkey. The isolated HT was radiolabeled with 131I (131I-HT) and the bioaffinity of this radiolabeled component of olive leaves extract was investigated by using in vivo/in vitro methods. It was found that HT could be radiolabeled with 131I in yields of 95.6±4.4% (n = 8), and in vivo studies showed that 131I-HT is taken up by urinary bladder, stomach, small intestine, large intestine, breast and prostate. Significant incorporation of activity was observed in cell lines via in vitro studies.

scholarly journals The role of phenolic compounds in the defense of sooty mold of olive leaves (Olea europea L.)

2015 ◽  
Vol 9 (15) ◽  
pp. 1075-1081
Author(s):  
Ilias Faiza ◽  
Bensehaila Sarra ◽  
Medjdoub Kenza ◽  
El Haci Imad ◽  
Gaouar Benyelles Nassira
Keyword(s):  
Phenolic Compounds ◽  
Olive Leaves ◽  
Sooty Mold ◽  
Olea Europea

scholarly journals Catechins as Tools to Understand the Molecular Basis of Neurodegeneration

Molecules ◽  
2020 ◽  
Vol 25 (16) ◽  
pp. 3571
Author(s):  
Karla Martinez Pomier ◽  
Rashik Ahmed ◽  
Giuseppe Melacini
Keyword(s):  
Phenolic Compounds ◽  
Neurodegenerative Disorders ◽  
Molecular Basis ◽  
Protein Misfolding ◽  
Molecular Mechanisms ◽  
Amyloid Aggregation ◽  
Amyloid Aggregates ◽  
Parkinson’S Diseases ◽  
Pharmacokinetic Properties ◽  
Self Association

Protein misfolding as well as the subsequent self-association and deposition of amyloid aggregates is implicated in the progression of several neurodegenerative disorders including Alzheimer’s and Parkinson’s diseases. Modulators of amyloidogenic aggregation serve as essential tools to dissect the underlying molecular mechanisms and may offer insight on potential therapeutic solutions. These modulators include green tea catechins, which are potent inhibitors of amyloid aggregation. Although catechins often exhibit poor pharmacokinetic properties and bioavailability, they are still essential tools for identifying the drivers of amyloid aggregation and for developing other aggregation modulators through structural mimicry. As an illustration of such strategies, here we review how catechins have been used to map the toxic surfaces of oligomeric amyloid-like species and develop catechin-based phenolic compounds with enhanced anti-amyloid activity.

Statistical optimization and kinetic analysis of the extraction of phenolic compounds from olive leaves

2019 ◽  
Vol 95 (2) ◽  
pp. 457-465 ◽  
Author(s):  
George K Lamprou ◽  
Anestis Vlysidis ◽  
Konstantinos Tzathas ◽  
Apostolos G Vlyssides
Keyword(s):  
Phenolic Compounds ◽  
Kinetic Analysis ◽  
Statistical Optimization ◽  
Olive Leaves
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