Selection of young patients using strict criteria allows an excellent chance of pregnancy when transferring a single emebryo while avoiding a high risk of multple gestation

Results of the study related to polymorphism of ACE gene (rs1799752)‎, integrin αIIbβ3, and CSK gene (rs1378942) influencing development of arterial hypertension in young patients with metabolic syndrome are presented. Hypertension as a component of the metabolic syndrome was detected in 15.0% of young patients. Prevalence of mutant alleles of the studied genes among the examined patients was quite high, so homozygous DD genotype was found in 21.6%, and mutant D allele of the ACE gene in 47.4%. A high risk of hypertension in patients with MS was detected in carriers of the T allele of the CSK (rs1378942) gene – 54.8%, which was most often observed in a combination of polymorphic ACE and CSK gene loci (p = 0.0053).

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Getting to Hope: Perspectives from Patients and Caregivers Living with Chronic Childhood Illness

Children ◽

10.3390/children8060525 ◽

2021 ◽

Vol 8 (6) ◽

pp. 525

Author(s):

Emily von Scheven ◽

Bhupinder K. Nahal ◽

Rosa Kelekian ◽

Christina Frenzel ◽

Victoria Vanderpoel ◽

...

Keyword(s):

Conceptual Model ◽

Research Question ◽

Young Patients ◽

Future Research ◽

Childhood Onset ◽

Virtual Focus Groups ◽

Definition Of ◽

Selection Of ◽

Chronic Childhood ◽

Research Studies

Promoting hope was identified in our prior work as the top priority research question among patients and caregivers with diverse childhood-onset chronic conditions. Here, we aimed to construct a conceptual model to guide future research studies of interventions to improve hope. We conducted eight monthly virtual focus groups and one virtual workshop with patients, caregivers, and researchers to explore key constructs to inform the model. Discussions were facilitated by Patient Co-Investigators. Participants developed a definition of hope and identified promotors and inhibitors that influence the experience of hope. We utilized qualitative methods to analyze findings and organize the promotors and inhibitors of hope within three strata of the socio-ecologic framework: structural, interpersonal, and intrapersonal. Participants identified three types of interventions to promote hope: resources, navigation, and activities to promote social connection. The hope conceptual model can be used to inform the selection of interventions to assess in future research studies aimed at improving hope and the specification of outcome measures to include in hope research studies. Inclusion of the health care system in the model provides direction for identifying strategies for improving the system and places responsibility on the system to do better to promote hope among young patients with chronic illness and their caregivers.

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High risk medicolegal autopsies: is a full postmortem examination necessary?

Journal of Clinical Pathology ◽

10.1136/jclinpath-2012-201137 ◽

2012 ◽

Vol 66 (1) ◽

pp. 1-7 ◽

Cited By ~ 9

Author(s):

Eve Patricia Fryer ◽

Zoe C Traill ◽

Rachel E Benamore ◽

Ian S D Roberts

Keyword(s):

High Risk ◽

Minimally Invasive ◽

Cause Of Death ◽

Drug Abusers ◽

Minimally Invasive Approach ◽

Invasive Approach ◽

External Examination ◽

Invasive Techniques ◽

Cocaine Toxicity ◽

Selection Of

AimsAiming to reduce the numbers of high risk autopsies, we use a minimally invasive approach. HIV/hepatitis C virus (HCV)-positive coronial referrals, mainly intravenous drug abusers, have full autopsy only if external examination, toxicology and/or postmortem CT scan do not provide the cause of death. In this study, we review and validate this protocol.Methods and results62 HIV/HCV-positive subjects were investigated. All had external examination, 59 toxicology and 24 CT. In 42/62, this minimally invasive approach provided a cause of death. Invasive autopsy was required in 20/62, CT/toxicology being inconclusive, giving a potential rather than definite cause of death. Autopsy findings provided the cause of death in 6/20; in the remainder, a negative autopsy allowed more weight to be given to toxicological results previously regarded as inconclusive. In order to validate selection of cases for invasive autopsy using history, external examination and toxicology, a separate group of 57 non-infectious full autopsies were analysed. These were consecutive cases in which there was a history that suggested drug abuse. A review pathologist, provided only with clinical summary, external findings and toxicology, formulated a cause of death. This formulation was compared with the original cause of death, based on full autopsy. The review pathologist correctly identified a drug-related death or requirement for full autopsy in 56/57 cases. In one case, diagnosed as cocaine toxicity by the review pathologist, autopsy additionally revealed subarachnoid haemorrhage and Berry aneurysm.ConclusionsThese findings support the use of minimally invasive techniques in high risk autopsies, which result in a two-thirds reduction in full postmortems.

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Early non-invasive selection of patients at high risk of severe hepatitis C recurrence after liver transplantation

Transplant Infectious Disease ◽

10.1111/tid.12526 ◽

2016 ◽

Vol 18 (3) ◽

pp. 471-479 ◽

Cited By ~ 9

Author(s):

G. Crespo ◽

M. Gambato ◽

O. Millán ◽

G. Casals ◽

P. Ruiz ◽

...

Keyword(s):

Liver Transplantation ◽

Hepatitis C ◽

High Risk ◽

Severe Hepatitis ◽

Non Invasive ◽

Hepatitis C Recurrence ◽

Selection Of Patients ◽

Selection Of

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Selection of women at high risk of breast cancer for initial screening

Journal of Chronic Diseases ◽

10.1016/0021-9681(86)90047-0 ◽

1986 ◽

Vol 39 (4) ◽

pp. 253-260 ◽

Cited By ~ 33

Author(s):

Martin T. Schechter ◽

Anthony B. Miller ◽

Cornelia J. Baines ◽

Geoffrey R. Howe

Keyword(s):

Breast Cancer ◽

High Risk ◽

Initial Screening ◽

Selection Of

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Programma 2000: Celebrating 10 Years of Activity of an Italian Pilot Programme on Early Intervention in Psychosis

Australian & New Zealand Journal of Psychiatry ◽

10.1080/00048670802512032 ◽

2008 ◽

Vol 42 (12) ◽

pp. 1003-1012 ◽

Cited By ~ 39

Author(s):

Angelo Cocchi ◽

Anna Meneghelli ◽

Antonio Preti

Keyword(s):

Early Intervention ◽

High Risk ◽

Rating Scale ◽

Young Patients ◽

Skills Training ◽

First Episode ◽

Global Functioning ◽

Adult Intelligence Scale ◽

Cognitive Behavioural ◽

Early Intervention In Psychosis

Objective: This paper describes the structure and the organization of the single Italian programme specifically targeted at the early detection of and interventions for subjects at onset of or at high risk of psychosis, Programma 2000. Methods: Programma 2000 is a comprehensive multi-modal protocol of early intervention in psychosis, set up in Milan in 1999. The service has been very active since its opening, and at the time of writing (spring (April) 2008), more than 300 young patients have been evaluated through a detailed protocol that embraces Health of the Nation Outcome Scale (HoNOS), Brief Psychiatric Rating Scale (BPRS), Cognitive Behavioural Assessment 2.0, Disability Assessment Schedule, Camberwell Family Interview, Wechsler Adult Intelligence Scale and the Early Recognition Inventory Retrospective Assessment of Symptoms. The treatment includes psychoeducation, cognitive behavioural therapy (CBT), both structured and unstructured psychosocial interventions and pharmacotherapy, when necessary. Results: The programme focuses on young people aged 17–30 years: to date, a total of 132 subjects with definite psychosis or within the high-risk category have been enrolled in treatment after assessment. Patients with first-episode psychosis were, on average and expectedly, more severe than those in the at-risk group, and were more likely to be prescribed antipsychotic drugs. A large majority of patients in both groups received tailored CBT; individual sessions of skills training were provided to two-thirds of patients. In both groups, improvement was found in both the BPRS and HoNOS, and in the level of global functioning as assessed on Global Assessment of Functioning at 6 month and 1 year follow up. Global functioning was more sensitive to change than symptom severity, reflecting the intensive and personalized efforts to improve social and role functioning in patients. Conclusions: Programma 2000 is still in development but it has already gained the support of therapists and other relevant people involved in the life of subjects at onset, or at high risk of psychosis.

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Exosome‐encapsulated microRNA‐4525, microRNA‐451a and microRNA‐21 in portal vein blood is a high‐sensitive liquid biomarker for the selection of high‐risk pancreatic ductal adenocarcinoma patients

Journal of Hepato-Biliary-Pancreatic Sciences ◽

10.1002/jhbp.601 ◽

2019 ◽

Vol 26 (2) ◽

pp. 63-72 ◽

Cited By ~ 7

Author(s):

Sachiyo Kawamura ◽

Hisae Iinuma ◽

Keita Wada ◽

Kunihiko Takahashi ◽

Shunryo Minezaki ◽

...

Keyword(s):

High Risk ◽

Portal Vein ◽

Pancreatic Ductal Adenocarcinoma ◽

Ductal Adenocarcinoma ◽

Selection Of

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Certain historical, practical and scientific aspects of prenatal diagnostics in st. Petersburg

Journal of obstetrics and women s diseases ◽

10.17816/jowd87156 ◽

2004 ◽

Vol 53 (1) ◽

pp. 82-88

Author(s):

V. S. Baranov

Keyword(s):

Prenatal Diagnosis ◽

High Risk ◽

Research Methods ◽

Rapid Growth ◽

Medical Genetics ◽

Practical Significance ◽

Non Invasive ◽

Methodological Problems ◽

Biochemical Research ◽

Selection Of

Prenatal diagnosis (PD), as a relatively new area of medical genetics, is experiencing a period of rapid growth. Methodological problems of PD associated with the selection of women at high risk of congenital and hereditary pathology, complex examination of the fetus using non-invasive (ultrasound) and invasive (cytogenetic, molecular, biochemical) research methods have already been resolved. Further increase in the effectiveness of PD, its scientific and practical significance depends entirely on the level of organization of this service in the field and its funding. An important role in the development of modern PD in Russia was played by the PD laboratory of the N.I. BEFORE. Otta RAMS.

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