COMPARISON OF DISPOSITION DECISIONS OF ELECTIVE FERTILITY PRESERVATION VERSUS FERTILITY TREATMENT PATIENT POPULATIONS UTILIZING ASSISTED REPRODUCTIVE TECHNOLOGIES

Both the Czech Republic and the United States are destinations for cross-border reproductive travellers. For North Americans, including Canadians, who opt to travel to the Czech Republic for IVF using an egg donor, they are entering a fertility industry that is anonymous. This makes the Czech Republic different from other European countries that necessitate open gamete donation, as in Austria, Germany and the United Kingdom. For reproductive travellers coming to the United States for fertility treatment, there is a wider menu of choices regarding egg donation given the vastly unregulated nature of the industry. More recently, professionals in the industry are pushing for ‘open’ egg donation. For intended parents traveling to either location seeking in vitro fertilization using an egg donor, they must choose whether or not to pursue open or closed donation. As pre-conception parents, they navigate competing discourses of healthy parenting of donor-conceived offspring. They must be reflexive about their choices, and protective when weighing their options, always keeping their future child's mental, physical and genetic health in mind. Drawing from ethnographic data collected over the course of six years in the United States and the Czech Republic, this paper will explore both programs, paying special attention to the question of how gamete donation and global assisted reproductive technologies intersect with different notions about healthy pre-conception parenting.

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Psychotherapy of a Relationship Break-Up in the Context of Assisted Reproductive Technologies

Counseling Psychology and Psychotherapy ◽

10.17759/cpp.2021290108 ◽

2021 ◽

Vol 29 (1) ◽

pp. 132-148

Author(s):

I.I. Znamenskaya ◽

M.R. Travkova ◽

K.R. Arutyunova

Keyword(s):

Decision Making ◽

Legal Status ◽

Ethical Issues ◽

Assisted Reproductive Technologies ◽

Reproductive Technologies ◽

The Other ◽

Fertility Treatment ◽

Break Up ◽

The One ◽

Cryopreserved Embryos

The paper is focused on ethical issues of making decisions about cryopreserved embryos in the context of relationship break-up in the framework of the embryo’s legal status and the church’s stand on the matter. All these issues can be viewed as part of a broader problem of intuitive and rational foundations for decision-making when facing difficult situations in life. On the one hand, the stressful context of the situation implies intuitive-driven decision-making; on the other hand, assisted reproductive technologies are largely counter-intuitive. We describe the peculiarities of family psychotherapy with mixed-agenda couples going through a divorce who have joint cryopreserved embryos but disagree on what to do with them. We introduce a protocol for psychotherapeutic work in the situation when one partner wishes to continue with the fertility treatment and have a child while the other partner is determined to utilize joint embryos as unwanted biological material. In addition, we discuss emotional and social complications that may arise (guilt, unfaithfulness of one of the partners, other losses, and grieving).

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Embryologist's Job in Assisted Reproductive Technologies and in Vitro Fertilization

International Journal of Scientific Research in Science and Technology ◽

10.32628/ijsrst218521 ◽

2021 ◽

pp. 108-115

Author(s):

Harsimrat Kaur ◽

Ram Dayal ◽

Kamla Singh

Keyword(s):

Genetic Screening ◽

Assisted Reproductive Technologies ◽

Genetic Diagnosis ◽

Reproductive Technologies ◽

Fertility Treatment ◽

Medical Professionals ◽

Vitro Fertilization ◽

Laboratory Environment ◽

Reproductive Research

What exactly does an embryologist do? is one of the most common question asked by patients and the possible answer could be that embryologist is the child’s first watchperson. The ability to grow embryos in laboratory environment was a huge scientific achievement. Scientists and Embryologists are involved in reproductive research and fertility treatment. The embryologist has a huge role to play in IVF/ICSI process and the contribution of embryologist is no less than infertility consultant. They might not be doctors, but they are highly trained medical professionals, holding a master’s degree or Ph.D. due to specialized nature of work. They are responsible for management and maintenance of laboratory used in creating embryos as well as monitoring those embryos. The important activities that embryologist does are maintaining the embryology lab (temperature, humidity, CO2 cylinder, diffusion gas and pH), oocyte screening during ovum pickup (OPU), incubation and checking of fertilization, embryo transfer, vitrification and embryo biopsy for pre-implantation genetic screening (PGS) or pre-implantation genetic diagnosis (PGD).

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Outcomes of pulmonary vascular disease in infants conceived with non‐IVF fertility treatment and assisted reproductive technologies at 1 year of age

Pediatric Pulmonology ◽

10.1002/ppul.24457 ◽

2019 ◽

Vol 54 (11) ◽

pp. 1844-1852

Author(s):

David C. Fineman ◽

Rebecca J. Baer ◽

Christina D. Chambers ◽

Satish Rajagopal ◽

Emin Maltepe ◽

...

Keyword(s):

Vascular Disease ◽

Assisted Reproductive Technologies ◽

Reproductive Technologies ◽

Fertility Treatment ◽

Pulmonary Vascular Disease

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Fertility Preservation in the Age of Assisted Reproductive Technologies

Obstetrics and Gynecology Clinics of North America ◽

10.1016/j.ogc.2014.09.004 ◽

2015 ◽

Vol 42 (1) ◽

pp. 39-54 ◽

Cited By ~ 15

Author(s):

Paul R. Brezina ◽

William H. Kutteh ◽

Amelia P. Bailey ◽

Jianchi Ding ◽

Raymond W. Ke ◽

...

Keyword(s):

Fertility Preservation ◽

Assisted Reproductive Technologies ◽

Reproductive Technologies

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Fertility preservation in reproductive-age women facing gonadotoxic treatments

Current Oncology ◽

10.3747/co.22.2334 ◽

2015 ◽

Vol 22 (4) ◽

pp. 294 ◽

Cited By ~ 13

Author(s):

J. Roberts ◽

R. Ronn ◽

N. Tallon ◽

H. Holzer

Keyword(s):

Fertility Preservation ◽

Multidisciplinary Approach ◽

Assisted Reproductive Technologies ◽

Reproductive Technologies ◽

Reproductive Age ◽

Future Fertility ◽

Fertility Sparing ◽

Cure Rates ◽

Reproductive Consequences

BackgroundAdvancements in the treatments for cancer and autoimmune and other hematologic conditionscontinue to improve survival and cure rates. Despite those changes, various gonadotoxic agents and other treatments can still compromise the future fertility of many women. Progress in medical and surgical reproductive technologies has helped to offset the reproductive consequences of the use of gonadotoxic therapies, and allows for future fertility and normal pregnancy.Methods A review of the literature was performed to outline the pathophysiology of gonadotoxicity from various treatments. The success of fertility preservation, fertility sparing, and cryopreservation options are reviewed. Barriers and facilitators to referral and oncofertility treatment in Canada are also outlined.ResultsAccording to the quality of the evidence, recommendations are made for fertility assessment, patient referral, cryopreservation, and other assisted reproductive technologies.ConclusionsTo ensure ongoing fertility in women undergoing gonadotoxic treatments, assisted reproductive technologies can be combined with a multidisciplinary approach to patient assessment and referral.

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Hot Topics on Fertility Preservation for Women and Girls—Current Research, Knowledge Gaps, and Future Possibilities

Journal of Clinical Medicine ◽

10.3390/jcm10081650 ◽

2021 ◽

Vol 10 (8) ◽

pp. 1650

Author(s):

Kenny A. Rodriguez-Wallberg ◽

Xia Hao ◽

Anna Marklund ◽

Gry Johansen ◽

Birgit Borgström ◽

...

Keyword(s):

Fertility Preservation ◽

Clinical Medicine ◽

Assisted Reproductive Technologies ◽

Negative Impact ◽

Experimental Studies ◽

Reproductive Technologies ◽

Research Knowledge ◽

Scientific Publications ◽

Gonadal Tissue ◽

Adults And Children

Fertility preservation is a novel clinical discipline aiming to protect the fertility potential of young adults and children at risk of infertility. The field is evolving quickly, enriched by advances in assisted reproductive technologies and cryopreservation methods, in addition to surgical developments. The best-characterized target group for fertility preservation is the patient population diagnosed with cancer at a young age since the bulk of the data indicates that the gonadotoxicity inherent to most cancer treatments induces iatrogenic infertility. Since improvements in cancer therapy have resulted in increasing numbers of long-term survivors, survivorship issues and the negative impact of infertility on the quality of life have come to the front line. These facts are reflected in an increasing number of scientific publications referring to clinical medicine and research in the field of fertility preservation. Cryopreservation of gametes, embryos, and gonadal tissue has achieved quality standards for clinical use, with the retrieval of gonadal tissue for cryopreservation being currently the only method feasible in prepubertal children. Additionally, the indications for fertility preservation beyond cancer are also increasing since a number of benign diseases and chronic conditions either require gonadotoxic treatments or are associated with premature follicle depletion. There are many remaining challenges, and current research encompasses clinical health care and caring sciences, ethics, societal, epidemiological, experimental studies, etc.

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The combination of polymorphisms of genes PAI-1 -675 5G>4G, FXIII: Val34Leu G>T and ITGA2: 807 C>T in women with infertility can be considered as a predictor of failures of assisted reproductive technologies

Тромбоз, гемостаз и реология ◽

10.25555/thr.2019.2.0881 ◽

2019 ◽

Author(s):

С.И. Сафиуллина ◽

Я.Н. Котова ◽

Е.С. Ворошилина ◽

Н.А. Илизарова ◽

Л.Ш. Ягудина ◽

...

Keyword(s):

Assisted Reproductive Technologies ◽

Treatment Effectiveness ◽

Risk Groups ◽

Reproductive Technologies ◽

Fertility Treatment ◽

Control Group ◽

Vitro Fertilization ◽

Ivf Failure ◽

Pai 1

Введение. Результативность программ вспомогательных репродуктивных технологий остается неизменно низкой и не превышает 40 по числу положительных результатов хорионического гонадотропина человека и 23 по коэффициенту рождаемости. Актуальны новые способы увеличения эффективности лечения методом экстракорпорального оплодотворения (ЭКО) и вынашивания наступившей беременности. Цель исследования: на основании исследования генов полиморфизмов системы гемостаза выделить группы риска неудачных исходов программ ЭКО у женщин с бесплодием. Материалы и методы. Изучена когорта 130 женщин, планирующих лечение бесплодия методом ЭКО, и 49 женщин группы контроля. У всех женщин исследованы наиболее распространенные полиморфизмы системы гемостаза: FV: 1691 GA, FII: 20210 GA, FXIII: Val34Leu GT, FGB: 455 GA, ITGA2: 807 СT, ITGB3: 1565 TC, PAI 1: 675 5G4G методом полимеразной цепной реакции, выполнено сравнение их распространенности с аналогичными показателями контрольной группы. Проанализированы частоты встречаемости и значимости изученных полиморфизмов в 140 протоколах с переносом эмбрионов в зависимости от исхода. Результаты. У женщин с бесплодием, планирующих проведение программы ЭКО, не обнаружено достоверных различий в частоте распространенности изученных полиморфизмов системы гемостаза по сравнению с контрольной группой. Установлена достоверно высокая частота распространения триады полиморфизмов PAI1: 675 4G/4G, ITGA2: 807 СT и FХIII: Val34Leu GT у женщин с отрицательными исходами программы ЭКО по сравнению с положительными исходами. Заключение. Перспективно выделение группы риска неудач ЭКО на основании результатов генетического тестирования полиморфизмов системы гемостаза. Introduction. The effectiveness of assisted reproductive technology programs remains consistently low and does not exceed 40 in the number of positive results of human chorionic gonadotropin and 23 in terms of the birth rate. New ways of increasing the treatment effectiveness with in vitro fertilization (IVF) and carrying the new pregnancy are actual. Aim: to identify risk groups of IVF unsuccessful outcomes in women with infertility by studying of hemostasis genes polymorphisms. Materials and methods. We examined 130 women planning fertility treatment using IVF and 49 women as a control group. In all women we studied the most common hemostasis polymorphisms: FV: 1691 GA, FII: 20210 GA, FXIII: Val34Leu GT, FGB: 455 GA, ITGA2: 807 СT, ITGB3: 1565 TC, PAI1: 675 5G4G by polymerase chain reaction, and compared their prevalence with similar parameters of the control group. We analyzed the frequency of occurrence and significance of studied polymorphisms in 140 protocols with embryo transfer in dependence to outcome. Results. In women with infertility planning IVF program, there were no significant differences in the prevalence rate of studied hemostasis polymorphisms in comparison with the control group. We revealed significantly high frequency of 3 polymorphisms occurrence PAI1: 675 4G/4G, ITGA2: 807 CT and FХIII: Val34Leu GT in women with negative outcomes of IVF program in comparison with positive outcomes. Conclusion. Identification of risk groups of IVF failure based on the results of genetic testing of hemostasis polymorphisms is promising.

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Assisted reproductive technologies and monozygous twins: implications for future study and clinical practice

Twin Research ◽

10.1375/twin.3.4.217 ◽

2000 ◽

Vol 3 (4) ◽

pp. 217-223 ◽

Cited By ~ 36

Author(s):

E Scott Sills ◽

Michael J Tucker ◽

Gianpiero D Palermo

Keyword(s):

Assisted Reproductive Technologies ◽

Reproductive Technologies ◽

Fertility Treatment ◽

Assisted Hatching ◽

Vitro Fertilization ◽

Culture Techniques ◽

Medical Hypothesis ◽

Mz Twins

AbstractThat the zona pellucida (ZP) plays a prominent role in the physiology of some human twinning is an attractive, albeit incompletely proven, medical hypothesis. Indeed, an association has been proposed between manipulation of the ZP and/or native ZP microarchitecture and monozygotic (MZ) twins. Ovulation induction also has been theoretically linked to in vivo ZP alterations facilitating MZ twin development. In vitro fertilization (IVF) relies on necessary (and, in some cases extended) embryo culture techniques potentially creating subtle ZP changes and subsequent MZ twinning. With growing experience in the assisted reproductive technologies and particularly IVF, some preliminary reports have noted an increased frequency of MZ twins after procedures that artificially breach the ZP (i.e., intracytoplasmic sperm injection [ICSI], or ‘assisted hatching’). Such ZP manipulations ostensibly enhance oocyte fertilization or facilitate blastocyst hatching, thus improving pregnancy rates for couples undergoing fertility treatment. Evidence exists both to challenge and support the connection between these phenomena and MZ twins. This report outlines the fundamental embryological processes believed responsible for these conflicting observations; the current literature on the subject of human ZP micro-manipulation and MZ twins is also discussed. Twin Research (2000) 3, 217–223.

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