Outcomes of pulmonary vascular disease in infants conceived with non‐IVF fertility treatment and assisted reproductive technologies at 1 year of age

2019 ◽  
Vol 54 (11) ◽  
pp. 1844-1852
Author(s):  
David C. Fineman ◽  
Rebecca J. Baer ◽  
Christina D. Chambers ◽  
Satish Rajagopal ◽  
Emin Maltepe ◽  
...  
Keyword(s):  
Vascular Disease ◽  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
Fertility Treatment ◽  
Pulmonary Vascular Disease

scholarly journals Is Information Power? Comparing Anonymous and Open Egg Donation

2017 ◽  
Vol 22 (2) ◽  
pp. 130-141 ◽  
Author(s):  
Amy Speier
Keyword(s):  
United States ◽  
Czech Republic ◽  
Assisted Reproductive Technologies ◽  
The United States ◽  
Reproductive Technologies ◽  
Fertility Treatment ◽  
Egg Donation ◽  
Gamete Donation ◽  
The Czech Republic ◽  
Egg Donor

Both the Czech Republic and the United States are destinations for cross-border reproductive travellers. For North Americans, including Canadians, who opt to travel to the Czech Republic for IVF using an egg donor, they are entering a fertility industry that is anonymous. This makes the Czech Republic different from other European countries that necessitate open gamete donation, as in Austria, Germany and the United Kingdom. For reproductive travellers coming to the United States for fertility treatment, there is a wider menu of choices regarding egg donation given the vastly unregulated nature of the industry. More recently, professionals in the industry are pushing for ‘open’ egg donation. For intended parents traveling to either location seeking in vitro fertilization using an egg donor, they must choose whether or not to pursue open or closed donation. As pre-conception parents, they navigate competing discourses of healthy parenting of donor-conceived offspring. They must be reflexive about their choices, and protective when weighing their options, always keeping their future child's mental, physical and genetic health in mind. Drawing from ethnographic data collected over the course of six years in the United States and the Czech Republic, this paper will explore both programs, paying special attention to the question of how gamete donation and global assisted reproductive technologies intersect with different notions about healthy pre-conception parenting.

scholarly journals Psychotherapy of a Relationship Break-Up in the Context of Assisted Reproductive Technologies

2021 ◽  
Vol 29 (1) ◽  
pp. 132-148
Author(s):  
I.I. Znamenskaya ◽  
M.R. Travkova ◽  
K.R. Arutyunova
Keyword(s):  
Decision Making ◽  
Legal Status ◽  
Ethical Issues ◽  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
The Other ◽  
Fertility Treatment ◽  
Break Up ◽  
The One ◽  
Cryopreserved Embryos

The paper is focused on ethical issues of making decisions about cryopreserved embryos in the context of relationship break-up in the framework of the embryo’s legal status and the church’s stand on the matter. All these issues can be viewed as part of a broader problem of intuitive and rational foundations for decision-making when facing difficult situations in life. On the one hand, the stressful context of the situation implies intuitive-driven decision-making; on the other hand, assisted reproductive technologies are largely counter-intuitive. We describe the peculiarities of family psychotherapy with mixed-agenda couples going through a divorce who have joint cryopreserved embryos but disagree on what to do with them. We introduce a protocol for psychotherapeutic work in the situation when one partner wishes to continue with the fertility treatment and have a child while the other partner is determined to utilize joint embryos as unwanted biological material. In addition, we discuss emotional and social complications that may arise (guilt, unfaithfulness of one of the partners, other losses, and grieving).

scholarly journals Embryologist's Job in Assisted Reproductive Technologies and in Vitro Fertilization

2021 ◽  
pp. 108-115
Author(s):  
Harsimrat Kaur ◽  
Ram Dayal ◽  
Kamla Singh
Keyword(s):  
Genetic Screening ◽  
Assisted Reproductive Technologies ◽  
Genetic Diagnosis ◽  
Reproductive Technologies ◽  
Fertility Treatment ◽  
Medical Professionals ◽  
Vitro Fertilization ◽  
Laboratory Environment ◽  
Reproductive Research

What exactly does an embryologist do? is one of the most common question asked by patients and the possible answer could be that embryologist is the child’s first watchperson. The ability to grow embryos in laboratory environment was a huge scientific achievement. Scientists and Embryologists are involved in reproductive research and fertility treatment. The embryologist has a huge role to play in IVF/ICSI process and the contribution of embryologist is no less than infertility consultant. They might not be doctors, but they are highly trained medical professionals, holding a master’s degree or Ph.D. due to specialized nature of work. They are responsible for management and maintenance of laboratory used in creating embryos as well as monitoring those embryos. The important activities that embryologist does are maintaining the embryology lab (temperature, humidity, CO2 cylinder, diffusion gas and pH), oocyte screening during ovum pickup (OPU), incubation and checking of fertilization, embryo transfer, vitrification and embryo biopsy for pre-implantation genetic screening (PGS) or pre-implantation genetic diagnosis (PGD).

The combination of polymorphisms of genes PAI-1 -675 5G>4G, FXIII: Val34Leu G>T and ITGA2: 807 C>T in women with infertility can be considered as a predictor of failures of assisted reproductive technologies

2019 ◽  
Author(s):  
С.И. Сафиуллина ◽  
Я.Н. Котова ◽  
Е.С. Ворошилина ◽  
Н.А. Илизарова ◽  
Л.Ш. Ягудина ◽  
...  
Keyword(s):  
Assisted Reproductive Technologies ◽  
Treatment Effectiveness ◽  
Risk Groups ◽  
Reproductive Technologies ◽  
Fertility Treatment ◽  
Control Group ◽  
Vitro Fertilization ◽  
Ivf Failure ◽  
Pai 1

Введение. Результативность программ вспомогательных репродуктивных технологий остается неизменно низкой и не превышает 40 по числу положительных результатов хорионического гонадотропина человека и 23 по коэффициенту рождаемости. Актуальны новые способы увеличения эффективности лечения методом экстракорпорального оплодотворения (ЭКО) и вынашивания наступившей беременности. Цель исследования: на основании исследования генов полиморфизмов системы гемостаза выделить группы риска неудачных исходов программ ЭКО у женщин с бесплодием. Материалы и методы. Изучена когорта 130 женщин, планирующих лечение бесплодия методом ЭКО, и 49 женщин группы контроля. У всех женщин исследованы наиболее распространенные полиморфизмы системы гемостаза: FV: 1691 GA, FII: 20210 GA, FXIII: Val34Leu GT, FGB: 455 GA, ITGA2: 807 СT, ITGB3: 1565 TC, PAI 1: 675 5G4G методом полимеразной цепной реакции, выполнено сравнение их распространенности с аналогичными показателями контрольной группы. Проанализированы частоты встречаемости и значимости изученных полиморфизмов в 140 протоколах с переносом эмбрионов в зависимости от исхода. Результаты. У женщин с бесплодием, планирующих проведение программы ЭКО, не обнаружено достоверных различий в частоте распространенности изученных полиморфизмов системы гемостаза по сравнению с контрольной группой. Установлена достоверно высокая частота распространения триады полиморфизмов PAI1: 675 4G/4G, ITGA2: 807 СT и FХIII: Val34Leu GT у женщин с отрицательными исходами программы ЭКО по сравнению с положительными исходами. Заключение. Перспективно выделение группы риска неудач ЭКО на основании результатов генетического тестирования полиморфизмов системы гемостаза. Introduction. The effectiveness of assisted reproductive technology programs remains consistently low and does not exceed 40 in the number of positive results of human chorionic gonadotropin and 23 in terms of the birth rate. New ways of increasing the treatment effectiveness with in vitro fertilization (IVF) and carrying the new pregnancy are actual. Aim: to identify risk groups of IVF unsuccessful outcomes in women with infertility by studying of hemostasis genes polymorphisms. Materials and methods. We examined 130 women planning fertility treatment using IVF and 49 women as a control group. In all women we studied the most common hemostasis polymorphisms: FV: 1691 GA, FII: 20210 GA, FXIII: Val34Leu GT, FGB: 455 GA, ITGA2: 807 СT, ITGB3: 1565 TC, PAI1: 675 5G4G by polymerase chain reaction, and compared their prevalence with similar parameters of the control group. We analyzed the frequency of occurrence and significance of studied polymorphisms in 140 protocols with embryo transfer in dependence to outcome. Results. In women with infertility planning IVF program, there were no significant differences in the prevalence rate of studied hemostasis polymorphisms in comparison with the control group. We revealed significantly high frequency of 3 polymorphisms occurrence PAI1: 675 4G/4G, ITGA2: 807 CT and FХIII: Val34Leu GT in women with negative outcomes of IVF program in comparison with positive outcomes. Conclusion. Identification of risk groups of IVF failure based on the results of genetic testing of hemostasis polymorphisms is promising.

Assisted reproductive technologies and monozygous twins: implications for future study and clinical practice

Twin Research ◽  
2000 ◽  
Vol 3 (4) ◽  
pp. 217-223 ◽  
Author(s):  
E Scott Sills ◽  
Michael J Tucker ◽  
Gianpiero D Palermo
Keyword(s):  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
Fertility Treatment ◽  
Assisted Hatching ◽  
Vitro Fertilization ◽  
Culture Techniques ◽  
Medical Hypothesis ◽  
Mz Twins

AbstractThat the zona pellucida (ZP) plays a prominent role in the physiology of some human twinning is an attractive, albeit incompletely proven, medical hypothesis. Indeed, an association has been proposed between manipulation of the ZP and/or native ZP microarchitecture and monozygotic (MZ) twins. Ovulation induction also has been theoretically linked to in vivo ZP alterations facilitating MZ twin development. In vitro fertilization (IVF) relies on necessary (and, in some cases extended) embryo culture techniques potentially creating subtle ZP changes and subsequent MZ twinning. With growing experience in the assisted reproductive technologies and particularly IVF, some preliminary reports have noted an increased frequency of MZ twins after procedures that artificially breach the ZP (i.e., intracytoplasmic sperm injection [ICSI], or ‘assisted hatching’). Such ZP manipulations ostensibly enhance oocyte fertilization or facilitate blastocyst hatching, thus improving pregnancy rates for couples undergoing fertility treatment. Evidence exists both to challenge and support the connection between these phenomena and MZ twins. This report outlines the fundamental embryological processes believed responsible for these conflicting observations; the current literature on the subject of human ZP micro-manipulation and MZ twins is also discussed. Twin Research (2000) 3, 217–223.

scholarly journals Women’s Knowledge and Awareness of the Effect of Age on Fertility in Kazakhstan

Sexes ◽  
2020 ◽  
Vol 1 (1) ◽  
pp. 60-71
Author(s):  
Antonio Sarría-Santamera ◽  
Gauri Bapayeva ◽  
Gulnara Utepova ◽  
Jelena Krstic ◽  
Sanja Terzic ◽  
...  
Keyword(s):  
Assisted Reproductive Technologies ◽  
Medical Center ◽  
Knowledge Score ◽  
Reproductive Technologies ◽  
Cross Sectional Study ◽  
Fertility Treatment ◽  
Cross Sectional ◽  
Women's Knowledge ◽  
Women’S Knowledge ◽  
Effect Of Age

An accurate understanding of reproductive facts is essential for appropriate decision making regarding whether, when, and how to conceive. The objective of this study was to investigate women’s knowledge of how age affects fertility and their knowledge about the effectiveness for assisted reproductive technologies for treating fertility. A cross-sectional study was conducted including women seeking fertility treatment at the University Medical Center, Nur-Sultan, Kazakhstan in 2018–2019. Patients were interviewed with a structured questionnaire. Socio-demographic, clinical characteristics, and knowledge and awareness about the implications of aging for fertility (advanced maternal age (AMA)) and pregnancy outcomes using fertility treatments (assisted reproductive technologies ((ART)) and the sum of both scores total knowledge score (TKS). TKS mean was 7.7 (SD = 2.1), AMA was 5.0 (SD = 1.5), and ART was 2.7 (SD = 1.5). No socio-demographic factors correlated with lower knowledge. Fertility knowledge was found to be low. No differences were found associated with socio-economic level, although they were identified in women with certain types of infertility and a history of gynecological problems. Delaying childbearing based on incorrect perceptions of female fertility could lead to involuntary childlessness. Health education regarding fertility has to be part of broader health promotion programs to enhance awareness of the effect of age on fertility.

scholarly journals Infertile Couples' Needs after Unsuccessful Fertility Treatment: a Qualitative Study

2019 ◽  
Vol 8 (2) ◽  
pp. 95-104 ◽  
Author(s):  
Samira Ebrahimzadeh Zagami ◽  
Robab Latifnejad Roudsari ◽  
Roksana Janghorban ◽  
Seyed Mojtaba Mousavi Bazaz ◽  
Maliheh Amirian ◽  
...  
Keyword(s):  
Qualitative Study ◽  
Treatment Failure ◽  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
Fertility Treatment ◽  
Structured Interviews ◽  
Need For Support ◽  
Conventional Content Analysis ◽  
Infertile Couples ◽  
Infertile Patients

Introduction: Infertility is a major medical issue. Investigations and treatment of infertility are the beginning of a complex, time-consuming and stressful process for couples that may fail well. The present study explored the needs of infertile couples following treatment failure with Assisted Reproductive Technologies (ARTs). Methods: A descriptive qualitative study was conducted in an Iranian infertility center, in the Northeast of the country between April 2016 and June 2017. The researchers recruited 29 individuals including 9 couples, 9 women and two men with primary infertility through purposive sampling. The data were collected using semi-structured interviews and analyzed iteratively, using conventional content analysis with MAXQDA software. Results: The main concepts obtained from the data were classified into one theme titled: ""The need for support"" and four main categories along with their subcategories, and included the need for psychological support, the need for more useful information, the need for social support and the need to access to supplementary services. Conclusion: The findings show that following treatment failure, the infertile patients’ expressed needs and preferences were not met. Identifying and meeting their needs may help the infertile couples to deal with ARTs failure and to reach a decision about future treatment.

scholarly journals Predictive value of ovarian hormone-producing function assessment in poor responders undergoing assisted reproductive technologies

2020 ◽  
Vol 68 (6) ◽  
pp. 7-18
Author(s):  
Alexandra I. Merkulova ◽  
Lyailya Kh. Dzhemlikhanova ◽  
Dariko A. Niauri ◽  
Alexander M. Gzgzyan ◽  
Igor Yu. Kogan ◽  
...  
Keyword(s):  
Follicular Fluid ◽  
Ovarian Stimulation ◽  
Ovarian Function ◽  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
Fertility Treatment ◽  
Total Testosterone ◽  
Poor Responders ◽  
Aromatase Activity ◽  
Serum Estradiol

Hypothesis/aims of study. The management of poor responders to ovarian stimulation for in vitro fertilization (IVF) has always been a challenge. It is difficult for both doctors and patients to make decision to proceed to oocyte donation or abandon fertility treatment. More predictors of successful IVF treatment in poor responders are needed. The aim of this study was to assess hormonal ovarian function in poor responders undergoing ovarian stimulation and to identify predictors of the chance of clinical pregnancy after IVF cycle. Study design, materials and methods. The study included 45 infertile patients undergoing ovarian stimulation with poor ovarian response according to the Bologna criteria. All patients underwent standard IVF or IVF/ICSI protocol using gonadotropin releasing hormone antagonists. Letrozole (5 mg/day) was administered during the first 5 days of stimulation in standard antagonist FSH/hMG protocol to 13 of the patients included in the study, with standard antagonist FSH/hMG protocol being only administered to other 32 patients. Serum and follicular fluid were collected at the time of follicle aspiration, and the concentrations of total testosterone, estradiol and androstenedione were determined. Results. Follicular fluid concentrations of testosterone and androstenedione were higher and serum estradiol level was lower in the letrozole group. The serum concentrations of testosterone and androstenedione were comparable in both groups, while the serum estradiol/testosterone ratio was lower in the letrozole group. The threshold level of estradiol/testosterone ratio 1000 on the day of oocyte retrieval above which pregnancy and implantation rates were increased was 1532.68 (odds ratio 7.0 (95% CI 1.3935.35), р = 0.02). Conclusion. Evaluating of the serum estradiol / testosterone ratio has been shown to determine aromatase activity of ovarian preovulatory follicles and to predict IVF outcome in poor responders undergoing assisted reproductive technology.

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