Curcumin extracts from Curcuma Longa – Improvement of concentration, purity, and stability in food-approved and water-soluble surfactant-free microemulsions

2021 ◽  
Vol 339 ◽  
pp. 128140
Author(s):  
Pierre Degot ◽  
Verena Huber ◽  
Didier Touraud ◽  
Werner Kunz
Keyword(s):  
Curcuma Longa ◽  
Water Soluble ◽  
Soluble Surfactant

Mineralization of water-in-oil emulsion droplets

2004 ◽  
Vol 847 ◽  
Author(s):  
Giulia Fornasieri ◽  
Stéphane Badaire ◽  
Rénal Vasco Backov ◽  
Philippe Poulin ◽  
Cécile Zakri ◽  
...  
Keyword(s):  
Continuous Phase ◽  
Water Soluble ◽  
Oil Emulsion ◽  
Emulsion Droplets ◽  
Emulsion Systems ◽  
Oil Water ◽  
Silica Precursor ◽  
Concentration Threshold ◽  
Water In Oil Emulsion ◽  
Soluble Surfactant

Using reverse emulsion systems, we were able to trigger mineralization confined at an oil-water interface. In this process, the alcoxide silica precursor is dissolved in the oil continuous phase of the emulsion and diffuses through the bulk to the interface where it starts to hydrolyze and condense as soon as a certain concentration threshold is attained. The process takes place only in the presence of a water soluble surfactant inside the droplet. This surfactant leads to the presence of a controlled mesoporosity inside the silica shells. The obtained objects could be used in different encapsulation applications.

scholarly journals Facile preparation of water soluble curcuminoids extracted from turmeric ( Curcuma longa L.) powder by using steviol glucosides

2017 ◽  
Vol 214 ◽  
pp. 366-373 ◽  
Author(s):  
Thi Thanh Hanh Nguyen ◽  
Jinbeom Si ◽  
Choongil Kang ◽  
Byoungsang Chung ◽  
Donghwa Chung ◽  
...  
Keyword(s):  
Curcuma Longa ◽  
Water Soluble ◽  
Facile Preparation

Role of manganese-based surfactant towards solubilization and photophysical properties of fluorescein

RSC Advances ◽  
2016 ◽  
Vol 6 (9) ◽  
pp. 7066-7077 ◽  
Author(s):  
Gurpreet Kaur ◽  
Preeti Garg ◽  
Ganga Ram Chaudhary
Keyword(s):  
Photophysical Properties ◽  
Water Soluble ◽  
Fluorescein Dye ◽  
Soluble Surfactant

Interactions between fluorescein dye and manganese-based, water-soluble surfactant for modulating photophysical properties of such photosensitizer in a metal-containing microheterogeneous environment and for evaluating their role in solubilization have been explored.

scholarly journals Quality Control Of Crude Drugs And Capsules Of Turmeric (Curcuma longa L.)

2018 ◽  
Vol 15 (2) ◽  
pp. 257
Author(s):  
Dwi Hartanti ◽  
Jirapat Theeravit
Keyword(s):  
Antioxidant Activity ◽  
Quality Control ◽  
Oil Content ◽  
Curcuma Longa ◽  
Volatile Oil ◽  
Water Soluble ◽  
Foreign Matter ◽  
Single Use ◽  
Crude Drugs ◽  
Layer Chromatography

Turmeric (Curcuma longa L.) is a medicinal plant commonly used in Thai Traditional Medicine (TTM), both in single use and formula. It has been known for its antioxidant activity and applied for management of many diseases. In this article, we reported some aspects of quality control of crude drugs and capsules of turmeric according to the standards set in Thai Herbal Pharmacopeia (THP). The results of our evaluations demonstrated that turmeric crude drugs met the criteria set in THP for microscopical identification, foreign matter (1.31%), loss on drying (6.89±0.174%), ethanol-soluble extractive (13.56%), water-soluble extractive (15.17%), and the profile of Thin Layer Chromatography (TLC) chromatogram. However, its volatile oil content (5.95%) was below the minimum value set in THP. The turmeric capsules met the criteria set in THP for loss on drying (8.64±0.093%), ethanol-soluble extractive (18.07%), water-soluble extractive (14.95%), and profile of TLC chromatogram.

scholarly journals Dot blot immunochemical and infrared analyses of the adhesive layer applied to the painting Imago Pietatis by Domenico Morone

2022 ◽  
Vol 72 (1) ◽  
Author(s):  
Cristina Cattò ◽  
Valentina Parodi ◽  
Alice Chiodelli ◽  
Francesca Cappitelli ◽  
Silvia Bruni
Keyword(s):  
Fifteenth Century ◽  
Minor Component ◽  
Adhesive Layer ◽  
Water Soluble ◽  
Animal Glue ◽  
Dot Blot ◽  
Polished Cross Section ◽  
Materials Used ◽  
A Minor ◽  
Soluble Surfactant

Abstract Purpose To investigate the nature of the materials used in the adhesive layer of the Imago Pietatis painting (end of the fifteenth century—beginning of the sixteenth century) by Domenico Morone as a prerequisite for its restoration. Methods Micro-FTIR spectra of the animal glue and a polished cross-section were acquired by a Jasco IRT3000 spectrometer, equipped with a 32× Cassegrain objective. A dot blot immunoassay was used to characterise a minor component of the adhesive layer. Results Micro-FTIR was used as an effective diagnostic tool to detect the major component of the adhesive layer and the binder of the paint. Despite the ageing, the complex matrix and the micro-size of the sample, using a dot blot immunoassay, it was possible to quantify 3.7 ± 2.0 ng of ovalbumin per microgram of sample (corresponding to 0.004 ± 0.002% of the weight). Conclusions The findings were in line with conservation practices described in the old treatises, confirming the correct interpretation of the adhesive layer compounds added to the painting and suggesting for the cleaning the use of an anionic water-soluble surfactant highly effective in the removing of proteinaceous materials.

scholarly journals Cytotoxic, Genotoxic and Senolytic Potential of Native and Micellar Curcumin

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2385
Author(s):  
Lea Beltzig ◽  
Anna Frumkina ◽  
Christian Schwarzenbach ◽  
Bernd Kaina
Keyword(s):  
Cell Death ◽  
Comet Assay ◽  
Cell Lines ◽  
Curcuma Longa ◽  
Dose Range ◽  
Bioactive Compound ◽  
Cell Types ◽  
Water Soluble ◽  
Genotoxic Effects

Background: Curcumin, a natural polyphenol and the principal bioactive compound in Curcuma longa, was reported to have anti-inflammatory, anti-cancer, anti-diabetic and anti-rheumatic activity. Curcumin is not only considered for preventive, but also for therapeutic, purposes in cancer therapy, which requires a killing effect on cancer cells. A drawback, however, is the low bioavailability of curcumin due to its insolubility in water. To circumvent this limitation, curcumin was administered in different water-soluble formulations, including liposomes or embedded into nanoscaled micelles. The high uptake rate of micellar curcumin makes it attractive also for cancer therapeutic strategies. Native curcumin solubilised in organic solvent was previously shown to be cytotoxic and bears a genotoxic potential. Corresponding studies with micellar curcumin are lacking. Methods: We compared the cytotoxic and genotoxic activity of native curcumin solubilised in ethanol (Cur-E) with curcumin embedded in micells (Cur-M). We measured cell death by MTT assays, apoptosis, necrosis by flow cytometry, senolysis by MTT and C12FDG and genotoxicity by FPG-alkaline and neutral singe-cell gel electrophoresis (comet assay). Results: Using a variety of primary and established cell lines, we show that Cur-E and Cur-M reduce the viability in all cell types in the same dose range. Cur-E and Cur-M induced dose-dependently apoptosis, but did not exhibit senolytic activity. In the cytotoxic dose range, Cur-E and Cur-M were positive in the alkaline and the neutral comet assay. Genotoxic effects vanished upon removal of curcumin, indicating efficient and complete repair of DNA damage. For inducing cell death, which was measured 48 h after the onset of treatment, permanent exposure was required while 60 min pulse-treatment was ineffective. In all assays, Cur-E and Cur-M were equally active, and the concentration above which significant cytotoxic and genotoxic effects were observed was 10 µM. Micelles not containing curcumin were completely inactive. Conclusions: The data show that micellar curcumin has the same cytotoxicity and genotoxicity profile as native curcumin. The effective concentration on different cell lines, including primary cells, was far above the curcumin concentration that can be achieved systemically in vivo, which leads us to conclude that native curcumin and curcumin administered as food supplement in a micellar formulation at the ADI level are not cytotoxic/genotoxic, indicating a wide margin of safety.

scholarly journals Standardization of the Ayurvedic Formulation Haridra Khanda Using High-Performance Thin-Layer Chromatography-Densitometry

2008 ◽  
Vol 91 (5) ◽  
pp. 1162-1168 ◽  
Author(s):  
Kedar Kumar Rout ◽  
Sagarika Parida ◽  
Sagar Kumar Mishra
Keyword(s):  
Thin Layer ◽  
High Performance ◽  
Curcuma Longa ◽  
Water Soluble ◽  
Trace Metal Analysis ◽  
Cell Structures ◽  
Microscopic Evaluation ◽  
Multiple Wavelengths ◽  
Layer Chromatography ◽  
Instrumental Precision

Abstract The present study aimed to standardize the Ayurvedic preparation Haridra Khanda containing Curcuma longa as a major ingredient. Various physicochemical parameters such as alcohol-soluble extractive, water-soluble extractive, total ash, and acid-insoluble ash were determined according to the Ayurvedic Pharmacopoeia of India. Microscopic evaluation of the formulation revealed the presence of various diagnostic cell structures of C. longa. Trace metal analysis indicated the absence of toxic metals such as As, Cd, Hg, and Pb. High-performance thin-layer chromatographic (HPTLC) fingerprint patterns at multiple wavelengths (254, 366, and 430 nm) identified the number of components present at each wavelength. The bioactive markers curcumin (C1), demethoxycurcumin (C2), and bisdemethoxycurcumin (C3) were quantified by using a simple, rapid, and efficient HPTLC method using plates precoated with silica gel 60F254 stationary phase. The instrumental precision [coefficient of variation (CV)] was 0.51, 0.64, and 0.79% and the repeatability of the method (CV) was 0.89, 1.11, and 0.95%, respectively, for C1 to C3. Limits of detection and quantitation for compounds C1 to C3 were 20, 20, and 15 ng and 50, 40, and 50 ng, respectively. Response was a linear function in the ranges of 50350, 40240, and 50300 ng with correlation coefficient (r) 0.9998, 0.9995, and 0.9992, respectively, for C1 to C3. The mean recovery values of 99.63 (C1), 98.65 (C2), and 98.97% (C3) indicated the excellent accuracy of the method. It is shown that HPTLC can be applied successfully for the marker evaluation of the formulation containing C. longa.

Turmerin: A water soluble antioxidant peptide from turmeric [Curcuma longa]

1992 ◽  
Vol 292 (2) ◽  
pp. 617-623 ◽  
Author(s):  
Leela Srinivas ◽  
V.K. Shalini ◽  
M. Shylaja
Keyword(s):  
Curcuma Longa ◽  
Water Soluble ◽  
Antioxidant Peptide
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