Quercetin is a substrate not an inhibitor of tyrosinase - Comments on “Quercetin as a tyrosinase inhibitor: Inhibitory activity, conformational change and mechanism” published by Fan et al. (2017)

2022 ◽  
pp. 110944
Author(s):  
Hubert Wojtasek
Keyword(s):  
Conformational Change ◽  
Inhibitory Activity ◽  
Tyrosinase Inhibitor

Quercetin as a tyrosinase inhibitor: Inhibitory activity, conformational change and mechanism

2017 ◽  
Vol 100 ◽  
pp. 226-233 ◽  
Author(s):  
Meihui Fan ◽  
Guowen Zhang ◽  
Xing Hu ◽  
Ximing Xu ◽  
Deming Gong
Keyword(s):  
Conformational Change ◽  
Inhibitory Activity ◽  
Tyrosinase Inhibitor

scholarly journals AKTIVITAS INHIBITOR TIROSINASE PADA EKSTRAK ALGA COKELAT SARGASSUM SP. AGARDH ASAL PESISIR LHOK BUBON, KABUPATEN ACEH BARAT

2018 ◽  
Vol 1 (1) ◽  
Author(s):  
Muhammad Gazali
Keyword(s):  
Inhibitory Activity ◽  
Brown Algae ◽  
Methanol Extract ◽  
Kojic Acid ◽  
Bioactive Compound ◽  
Positive Control ◽  
Marine Macroalgae ◽  
Tyrosinase Inhibitor ◽  
Tyrosinase Inhibitory Activity ◽  
New Finding

Seaweeds are marine macro algae that can be found attach to the bottom shallow coastal waters with subsrate as attached media. There are three major groups of seaweeds namely brown algae (Phaeophyta), red (Rhodophyta) and green (Chlorophyta). Sargassum sp is one of brown algae which mostly found in the Lhok Bubon Coastal West of Aceh. Recently, exploration of marine macroalgae as bioactive sources was investigated. Seaweed contains bioactive compound which can serve as a defense from ultraviolet radiation that caused hyperpigmentation effect. The aiming of this study is to analyse the tyrosinase inhibitory activity of Sargassum sp extract from Lhok Bubon Coastal Area, West of Aceh. The results shown that the methanol extract of Sargassum sp possess phytochemical properties such as fenol, alkaloid and triterpenoid. Tyrosinase inhibitory activity of Sargassum sp methanol extract  is the best extract which can be inhibit  monophenolase with  IC50 : 1111.49 µg/ml and IC50 = 1582.31 µg/ml in diphenolase pathway with kojic acid as positive control. Moreover, etyl asetate and n-hexane extract have no activity of tyrosinase inhibitor. Therefore, new finding of tyrosinase inhibitor agent from marine macroalgae Sargassum sp give the fruitfull information for cosmeceutical industry.Keywords : Lhok Bubon, Brown Algae, Sargassum sp, Tyrosinase Inhibitor

scholarly journals Tyrosinase Inhibitor and Antioxidant Activity of Seaweed Powder from Fresh and Dried Sargassum plagyophyllum

2018 ◽  
Vol 20 (3) ◽  
pp. 488 ◽  
Author(s):  
Ayun Erwina Arifianti ◽  
Effionora Anwar ◽  
Nurjanah Nurjanah
Keyword(s):  
Antioxidant Activity ◽  
Ascorbic Acid ◽  
Active Substance ◽  
Inhibitory Activity ◽  
Kojic Acid ◽  
Radical Scavenging ◽  
Tyrosinase Inhibitor ◽  
Optimal Result ◽  
Ic50 Values ◽  
Skin Lightening

<p>Sargassum plagyophyllum from Sargassaceae family contains various bioactive compounds, namely<br />phlorotannin which is reported as an antioxidant and tyrosinase inhibitor. Tyrosinase inhibitor and<br />antioxidant activity from seaweed powder that obtained from seaweed’s slurry have not been reported. Thus,<br />this study was aimed to obtain the best seaweed slurry and powder from S. plagyophyllum based on tyrosinase<br />inhibitor and antioxidant activity, so it can be used as active substance in skin lightening cosmetic formula.<br />S. plagyophyllum which prepared fresh and dried was processed into seaweed slurry and lyophilization<br />to form powder. Antioxidant activity which was determined by 2,2-Diphenyl-1-picrylhydrazyl (DPPH)<br />radical scavenging method found the IC50 values of ascorbic acid was 0.0035 mg/mL; fresh slurry 27.31<br />mg/mL; dried slurry 41.13 mg/mL; fresh powder 2.21 mg/mL; and dried powder 13.18 mg/mL. Moreover,<br />the tyrosinase inhibitory activity which was measured by enzimatic reaction with L-tyrosine as substrate<br />found IC50 values kojic acid 0.0076 mg/mL; fresh powder 4.97 mg/mL; and dried powder 11.35 mg/mL. Seaweed powder obtained from fresh ingredient is the most optimal result based on its tyrosinase inhibitor<br />and antioxidant activity, thus potential to be developed further as active substance for lightening cosmetic<br />formula.<br /><br /></p>

scholarly journals POTENSI MAKROALGA PADINA AUSTRALIS (HAUCK 1887) DI BARAT SELATAN ACEH SEBAGAI AGEN INHIBITOR TIROSINASE

2018 ◽  
Vol 5 (1) ◽  
pp. 71
Author(s):  
Mohamad Gazali ◽  
Eri Safutra ◽  
Zulfadhli Zulfadhli
Keyword(s):  
Inhibitory Activity ◽  
Brown Algae ◽  
Methanol Extract ◽  
Bioactive Compound ◽  
Positive Control ◽  
Raw Material ◽  
Marine Macroalgae ◽  
Tyrosinase Inhibitor ◽  
Tyrosinase Inhibitory Activity ◽  
New Finding

Seaweeds are marine macro algae that can be found attach to the bottom shallow coastal waters. There are three major groups of seaweeds namely brown algae (Phaeophyta), red (Rhodophyta) and green (Chlorophyta). Padina australis is one of brown algae which mostly found in the West-South of Aceh coastal Area.  Seaweed contains bioactive compound which can serve as a defense from ultraviolet radiation that caused hyperpigmentation effect The purpose of this study is to analyse the tyrosinase inhibitory activity of P. australis extract from West-South Aceh. The results shown that the methanol extract of P. australis possess phytochemical properties such as flavonoids, tannin and saponin. tyrosinase inhibitory activity of P. australis  methanol extract  is the best extract which can be inhibit monophenolase with  IC50 : 293.520 µg/ml and IC50 = 13.571.067 µg/ml in diphenolase pathway with kojic acid as positive control. Moreover, chloroform and n-hexane extract have no activity of tyrosinase inhibitor. Therefore, new finding of tyrosinase inhibitor agent from marine macroalgae P. australis give the fruitfull information for cosmeceutical industry. P. australis parts could be complementary each other in providing the raw material of cosmetic product.

scholarly journals Identification by shape-based virtual screening and evaluation of new tyrosinase inhibitors

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e4206 ◽  
Author(s):  
Qi Li ◽  
Hongyu Yang ◽  
Jun Mo ◽  
Yao Chen ◽  
Yue Wu ◽  
...  
Keyword(s):  
Virtual Screening ◽  
Inhibitory Activity ◽  
Skin Pigmentation ◽  
Competitive Inhibitor ◽  
Tyrosinase Inhibitor ◽  
Starting Point ◽  
Good Starting Point ◽  
Tyrosinase Inhibitors ◽  
Dopa Formation ◽  
Potent Inhibitory Activity

Targeting tyrosinase is considered to be an effective way to control the production of melanin. Tyrosinase inhibitor is anticipated to provide new therapy to prevent skin pigmentation, melanoma and neurodegenerative diseases. Herein, we report our results in identifying new tyrosinase inhibitors. The shape-based virtual screening was performed to discover new tyrosinase inhibitors. Thirteen potential hits derived from virtual screening were tested by biological determinations. Compound 5186-0429 exhibited the most potent inhibitory activity. It dose-dependently inhibited the activity of tyrosinase, with the IC50 values 6.2 ± 2.0 µM and 10.3 ± 5.4 µM on tyrosine and L-Dopa formation, respectively. The kinetic study of 5186-0429 demonstrated that this compound acted as a competitive inhibitor. We believe the discoveries here could serve as a good starting point for further design of potent tyrosinase inhibitor.

Tyrosinase Inhibitor Fatty Ester and a Quinoline Alkaloid from Skimmia laureola

2005 ◽  
Vol 60 (11) ◽  
pp. 1186-1191 ◽  
Author(s):  
Nighat Sultana ◽  
Tariq H. Khan ◽  
Keyword(s):  
Inhibitory Activity ◽  
Fatty Ester ◽  
Tyrosinase Inhibitor ◽  
Aerial Parts ◽  
Quinoline Alkaloid

Aerial parts of Skimmia laureola yielded a new tyrosinase inhibitor fatty ester, (+)-skimmidiol (1), and a new alkaloid ribaliprenylene (2). The configuration at C-3’ in 1 was established by Horeau’s procedure. Compound 1 was screened for its enzyme inhibitory activity against tyrosinase (E.C.1.14.18.1), exhibiting activity with IC50 51.25±1.10165 μM.

2-(4-Fluorophenyl)-quinazolin-4(3H)-one as a novel tyrosinase inhibitor: Synthesis, inhibitory activity, and mechanism

2016 ◽  
Vol 24 (19) ◽  
pp. 4620-4625 ◽  
Author(s):  
Rui Wang ◽  
Wei-Ming Chai ◽  
Qin Yang ◽  
Man-Kun Wei ◽  
Yiyuan Peng
Keyword(s):  
Inhibitory Activity ◽  
Tyrosinase Inhibitor

scholarly journals Tyrosinase Inhibitory Activity, 3D QSAR, and Molecular Docking Study of 2,5-Disubstituted-1,3,4-Oxadiazoles

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Ramesh L. Sawant ◽  
Prashant D. Lanke ◽  
Jyoti B. Wadekar
Keyword(s):  
Enzyme Inhibition ◽  
Inhibitory Activity ◽  
3D Qsar ◽  
Docking Study ◽  
Docking Studies ◽  
Maximum Activity ◽  
Tyrosinase Inhibitor ◽  
Molecular Docking Study ◽  
Tyrosinase Inhibitory Activity ◽  
Vlife Mds

In continuation with our research program, in search of potent enzyme tyrosinase inhibitor, a series of synthesized 2,5-disubstituted 1,3,4-oxadiazoles have been evaluated for enzyme tyrosinase inhibitory activity. Subsequently, 3D QSAR and docking studies were performed to find optimum structural requirements for potent enzyme tyrosinase inhibitor from this series. The synthesized 20 compounds of 2,5-disubstituted-1,3,4-oxadiazole series were screened for mushroom tyrosinase inhibitory activity at various concentrations by enzyme inhibition assay. The percentage enzyme inhibition was calculated by recording absorbance at 492 nm with microplate reader. 3D QSAR and docking studies were performed using VLife MDS 3.5 software. In the series 2,5-disubstituted-1,3,4-oxadiazoles enzyme tyrosinase inhibitory activity was found to be dose dependent with maximum activity for compounds4c,4h,4m, and4r. 3D QSAR and docking studies revealed that more electropositive and less bulky substituents if placed on 1,3,4-oxadiazole nucleus may result in better tyrosinase inhibitory activity in the series.

Phlorotannins Derived From the Brown Alga Colpomenia bullosa as Tyrosinase Inhibitors

2021 ◽  
Vol 16 (7) ◽  
pp. 1934578X2110213
Author(s):  
Hideyuki Kurihara ◽  
Kazuki Kujira
Keyword(s):  
Inhibitory Activity ◽  
Brown Alga ◽  
Molecular Structures ◽  
Free Form ◽  
Biosynthesis Pathway ◽  
Tyrosinase Inhibitor ◽  
Melanin Biosynthesis ◽  
Tyrosinase Inhibitory Activity ◽  
Tyrosinase Inhibitors ◽  
Potential Use

Tyrosinase catalyzes hydroxylation of L-tyrosine and dehydrogenation of L-DOPA in the melanin biosynthesis pathway. Tyrosinase inhibitors have potential use as cosmetic whitening agents and for preventing seafood deterioration. In this report, tyrosinase inhibitors extracted from brown alga Colpomenia bullosa (Scytosiphonaceae, Scytosiphonales) were investigated. Inhibitory principles were isolated from the extract and identified as phlorotannins, phloroglucinol (1), diphlorethol (2), triphlorethol C (3), which have not been isolated in a free form previously, and fucophlorethol C (4). Compounds 3 and 4 have not been reported previously as tyrosinase inhibitors. Triphlorethol C (3) was the most potent tyrosinase inhibitor among the phlorotannins isolated, whereas isomeric fucophlorethol C (4) displayed the weakest inhibitory activity. The results suggest that molecular structures of phlorotannins strongly affect their tyrosinase inhibitory activity.

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