Dietary conjugated linoleic acid modulates morphology, selective immune parameters, and gene expressions in the intestine of grass carp

The aim of this study was to determine the influence of dietary supplementation of conjugated linoleic acid (CLA) on some immune system parameters in piglets. Forty-two weaned piglets, 12.44 ± 1.96 kg liveweight, were fed diets containing 1% sunflower oil (control, C), 0.5% CLA plus 0.5% sunflower oil (T1), and 1% CLA (T2). After 28, d serum lysozyme (1.39, 1.77 and 1.86 μg mL–1, respectively, for C, T1 a nd T2 groups; P < 0.01) and total serum immunoglobulin G (IgG) (1548, 1930, 2075 mg dL–1, respectively, for C, T1 and T2 groups; P < 0.05) were higher in piglets fed dietary CLA. No significant effect on serum α-1-acyl glycoprotein (AGP) was observed. These results support the view that CLA favorably influences immune response. Key words: Nutrition, CLA, immune response, piglets

Download Full-text

Dietary conjugated linoleic acid supplementation alleviates high lipid-induced intestinal damage in grass carp (Ctenopharyngodon idella)

Israeli Journal of Aquaculture - Bamidgeh ◽

10.46989/001c.23507 ◽

2021 ◽

Author(s):

Yang Yang ◽

Hongsen Xu ◽

Jiazhi Chang ◽

Bing Hu ◽

Jun Liu ◽

...

Keyword(s):

Linoleic Acid ◽

Conjugated Linoleic Acid ◽

Grass Carp ◽

Ctenopharyngodon Idella ◽

Intestinal Damage ◽

Acid Supplementation ◽

High Lipid ◽

Grass Carp Ctenopharyngodon Idella ◽

Dietary Conjugated Linoleic Acid

Download Full-text

Influences of dietary conjugated linoleic acid (CLA) and total lysine content on growth, carcass characteristics and meat quality of heavy pigs

Meat Science ◽

10.1016/j.meatsci.2007.10.001 ◽

2008 ◽

Vol 79 (2) ◽

pp. 307-316 ◽

Cited By ~ 21

Author(s):

C. Corino ◽

M. Musella ◽

G. Pastorelli ◽

R. Rossi ◽

K. Paolone ◽

...

Keyword(s):

Linoleic Acid ◽

Conjugated Linoleic Acid ◽

Meat Quality ◽

Carcass Characteristics ◽

Lysine Content ◽

Dietary Conjugated Linoleic Acid

Download Full-text

Dietary conjugated linoleic acid (CLA) induces apoptosis of colonic mucosa in 1,2-dimethylhydrazine-treated rats: a possible mechanism of the anticarcinogenic effect by CLA

British Journal Of Nutrition ◽

10.1079/bjn2001445 ◽

2001 ◽

Vol 86 (5) ◽

pp. 549-555 ◽

Cited By ~ 77

Author(s):

Hyun S. Park ◽

Ji H. Ryu ◽

Yeong L. Ha ◽

Jung H. Y. Park

Keyword(s):

Linoleic Acid ◽

Conjugated Linoleic Acid ◽

Control Diet ◽

Terminal Deoxynucleotidyl Transferase ◽

Prostaglandin E ◽

Dependent Manner ◽

Sprague Dawley ◽

Tumour Incidence ◽

Sprague Dawley Rats ◽

Dietary Conjugated Linoleic Acid

One of the objectives of the present study was to investigate whether 1 % conjugated linoleic acid (CLA) in the diet reduced tumour incidence in the colon of 1,2-dimethylhydrazine (DMH)-treated rats. Colon cancer was induced by injecting 6-week-old, male, Sprague–Dawley rats with 15 mg/kg DMH twice per week for 6 weeks. They were fed either 1 % CLA or a control diet ad libitum for 30 weeks. Dietary CLA significantly decreased colon tumour incidence (P<0·05). Our second objective was to investigate whether apoptosis in the colon mucosa of DMH-treated rats was affected by the amount of dietary CLA and whether the changes in apoptosis were related to those in fatty acid-responsive biomarkers. For this purpose, rats were killed after being fed a diet containing 0 %, 0·5 %, 1 % or 1·5 % CLA for 14 weeks. CLA was undetected in the mucosa of rats fed the 0 % CLA diet and increased to 5·9 mg/g phospholipid in rats fed the 0·5 % diet. The apoptotic index estimated by the terminal deoxynucleotidyl transferase-mediated dUTP nick and labelling technique was increased by 251 % and the 1,2-diacylglycerol content was decreased by 57 % in rats fed 0·5 % CLA. No further changes in these variables were observed when CLA in the diet was raised to 1·0 % or 1·5 %. However, dietary CLA decreased mucosal levels of prostaglandin E2, thromboxane B2 and arachidonic acid in a dose-dependent manner. The present data indicate that dietary CLA can inhibit DMH-induced colon carcinogenesis by mechanisms probably involving increased apoptosis.

Download Full-text