The -866G/A polymorphism in the promoter of the UCP2 gene is associated with risk for type 2 diabetes and with decreased insulin levels

Gene ◽  
2019 ◽  
Vol 701 ◽  
pp. 125-130 ◽  
Author(s):  
Panneerselvam Gomathi ◽  
Apurwa P. Samarth ◽  
Nancy Bright Arul Joseph Raj ◽  
Sundaresan Sasikumar ◽  
Ponniah Senthil Murugan ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Levels ◽  
Ucp2 Gene

scholarly journals An anxiolytic drug buspirone ameliorates hyperglycemia and endothelial dysfunction in type 2 diabetic rat model

2020 ◽  
Vol 45 (4) ◽  
pp. 397-404
Author(s):  
Tugba Gurpinar Çavuşoğlu ◽  
Ertan Darıverenli ◽  
Kamil Vural ◽  
Nuran Ekerbicer ◽  
Cevval Ulman ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Endothelial Dysfunction ◽  
Vascular Function ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Insulin Levels ◽  
Type 2 Diabetic

AbstractObjectivesType 2 diabetes is a common metabolic disease and anxiety disorders are very common among diabetics. Buspirone is used in the treatment of anxiety, also having blood glucose-lowering effects. The aim of the study was to investigate the effects of buspirone on the glucose and lipid metabolism as well as vascular function in type 2 diabetic rats.MethodsA type 2-diabetic model was induced through a high-fat diet for eight weeks followed by the administration of low-dose streptozotocin (35 mg/kg, intraperitoneal) in rats. Buspirone was given at two different doses (1.5 mg/kg/d and 5 mg/kg/d) and combined with metformin (300 mg/kg/d). The fasting glucose and insulin levels, lipid profile were analyzed, and vascular response measured from the thoracic aorta was also evaluated.ResultsBoth doses of buspirone caused a significant improvement in fasting blood glucose levels. In particular, the buspirone treatment, combined with metformin, improved endothelial dysfunction and was found to be correlated with decreased nitrate/nitrite levels.ConclusionsBuspirone may be effective in the treatment of type 2 diabetes, either alone or in combination with other treatments, particularly in terms of endothelial dysfunction, inflammation and impaired blood glucose, and insulin levels.

An association between glycine and insulin levels is observed in patients with pulmonary tuberculosis and type 2 diabetes

2020 ◽  
Vol 39 (10) ◽  
pp. 3019-3023
Author(s):  
Mariela Zenil-Vega ◽  
Eduarda Cerón ◽  
Guadalupe López-Bello ◽  
Julia Moreno ◽  
Eliuth Juárez-Cruz ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Pulmonary Tuberculosis ◽  
Insulin Levels

scholarly journals The Relationship between Dietary Habits, Blood Glucose and Insulin Levels among People without Cardiovascular Disease and Type 2 Diabetes; The ATTICA Study

2005 ◽  
Vol 2 (4) ◽  
pp. 208-208 ◽  
Author(s):  
Demosthenes B. Panagiotakos ◽  
Natalia Tzima ◽  
Christos Pitsavos ◽  
Christina Chrysohoou ◽  
Emilia Papakonstantinou ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Blood Glucose ◽  
Dietary Habits ◽  
Insulin Levels ◽  
The Relationship

scholarly journals The Effect ofTinospora crispaon Serum Glucose and Insulin Levels in Patients with Type 2 Diabetes Mellitus

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Theerawut Klangjareonchai ◽  
Chulaporn Roongpisuthipong
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Healthy Subjects ◽  
Statistical Significance ◽  
Area Under The Curve ◽  
Serum Glucose ◽  
Dry Powder ◽  
Insulin Levels

Objective. To determine the effects ofTinospora crispaon serum glucose and insulin levels in healthy subjects and patients with type 2 diabetes mellitus.Method. Serum from 10 healthy subjects and 10 diabetic participants, who had fasted overnight, were obtained every 30–60 minutes during the 3 hours of continued fasting and during the 3 hours after ingestion of 75 g of glucose with or without ingestion of 125 or 250 g ofTinospora crispadry powder capsule. Glucose and Insulin levels were analyzed and the areas under the curve for mean serum glucose and insulin levels were calculated.Result. The areas under the curve of mean serum glucose and insulin levels in both healthy and diabetic participants were not significantly different between with or withoutTinospora crispadry powder capsule. In diabetic participants the area under the curve of glucose was slightly lesser when 250 mg ofTinospora crispawas ingested, but not reaching statistical significance (478 and 444 mg min/ml, resp.,P=0.57).Conclusion. The results suggest thatTinospora crispaingestion cannot affect serum glucose and insulin levels in healthy subjects or patients with type 2 diabetes mellitus.

scholarly journals Inhibition of Dipeptidyl Peptidase-4 Reduces Glycemia, Sustains Insulin Levels, and Reduces Glucagon Levels in Type 2 Diabetes

2004 ◽  
Vol 89 (5) ◽  
pp. 2078-2084 ◽  
Author(s):  
Bo Ahrén ◽  
Mona Landin-Olsson ◽  
Per-Anders Jansson ◽  
Maria Svensson ◽  
David Holmes ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase 4 ◽  
Insulin Levels

Peripheral Insulin Extraction in Non-Diabetic Subjects and Type 2 Diabetes Mellitus Patients

2018 ◽  
Vol 128 (08) ◽  
pp. 520-527
Author(s):  
Daniël H. van Raalte ◽  
Eva van der Palen ◽  
Pauline Idema ◽  
Liza Wong ◽  
Sander W. M. Keet ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Peripheral Circulation ◽  
Cross Sectional Study ◽  
Capillary Endothelium ◽  
Cross Sectional ◽  
Insulin Levels ◽  
Glucose Levels ◽  
Novel Target ◽  
Insulin Uptake

Abstract Background Insulin has to be transported across the capillary endothelium to stimulate muscle glucose uptake. We investigated insulin uptake from the peripheral circulation in non-diabetic (ND) individuals and in type 2 diabetes (T2D) patients. Methods Single-center cross-sectional study involving 40 ND (age 65±11 years) and 30 T2D patients (age 67±8 years). Thirty-six participants were studied in the fasted state (22 ND subjects and 14 T2D patients termed NDF and T2DF) and 34 participants 1-h following a glucose challenge (18 ND subjects and 16 T2D patients indicated as NDG and T2DG). Main outcome measure was fractional extraction (FE) of insulin (FEins) and glucose using the forearm balance method. Results In NDF, FEins was 18 (10–26) % at lower insulin levels (63 51–80] pmol/l), while in NDG at higher insulin levels (776 [543–1176] pmol/l), FEins was 9 (4–16) % (p = 0.01 vs. NDF). In NDF only, a negative correlation was observed between FEins and arterial plasma insulin load (rho = − 0.575;p = 0.006) and fasting plasma glucose levels (rho = − 0.551;p = 0.01). In T2DF FEins was 6 (1–19) % and not different from FEins in T2DG (10 2–14) %), and was not associated to fasting glucose. FEins tended to be higher in NDF compared to T2DF (p = 0.07). Discussion We propose that in ND individuals, besides passive diffusion, an active high-affinity pathway with limited capacity around lower physiologic insulin levels exists for insulin transendothelial transport, contributing to glycemic control. In T2D patients, this mechanism of peripheral insulin uptake is diminished or even absent. Modulation of insulin extraction from the circulation may be a novel target to improve glucose metabolism in T2D.

scholarly journals The Acute Effects of Low-Dose TNF-αon Glucose Metabolism andβ-Cell Function in Humans

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Tobias Ibfelt ◽  
Christian P. Fischer ◽  
Peter Plomgaard ◽  
Gerrit van Hall ◽  
Bente Klarlund Pedersen
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Secretion ◽  
Low Dose ◽  
Cell Function ◽  
Low Grade ◽  
Intravenous Glucose ◽  
Insulin Levels ◽  
Basal Period

Type 2 diabetes is characterized by increased insulin resistance and impaired insulin secretion. Type 2 diabetes is also associated with low-grade inflammation and increased levels of proinflammatory cytokines such as TNF-α. TNF-αhas been shown to impair peripheral insulin signalingin vitroandin vivo. However, it is unclear whether TNF-αmay also affect endogenous glucose production (EGP) during fasting and glucose-stimulated insulin secretion (GSIS)in vivo. We hypothesized that low-dose TNF-αwould increase EGP and attenuate GSIS. Recombinant human TNF-αor placebo was infused in healthy, nondiabetic young men (n=10) during a 4-hour basal period followed by an intravenous glucose tolerance test (IVGTT). TNF-αlowered insulin levels by 12% during the basal period (P<0.05). In response to the IVGTT, insulin levels increased markedly in both trials, but there was no difference between trials. Compared to placebo, TNF-αdid not affect EGP during the basal period. Our results indicate that TNF-αacutely lowers basal plasma insulin levels but does not impair GSIS. The mechanisms behind this are unknown but we suggest that it may be due to TNF-αincreasing clearance of insulin from plasma without impairing beta-cell function or hepatic insulin sensitivity.

scholarly journals Subgroup analysis of proinsulin and insulin levels reveals novel correlations to metabolic indicators of type 2 diabetes

Aging ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 10715-10735
Author(s):  
Tangying Li ◽  
Huibiao Quan ◽  
Huachuan Zhang ◽  
Leweihua Lin ◽  
Lu Lin ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Subgroup Analysis ◽  
Insulin Levels
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