Gamma-Linolenic Acid Can Increase Serum Active GLP-1, Insulin Levels and Decrease Blood Glucose in Type 2 Diabetes.

2010 ◽  
pp. P3-508-P3-508
Author(s):  
KW Lee ◽  
DM Lim ◽  
JY Kim ◽  
SY Yang ◽  
KY Park ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Linolenic Acid ◽  
Gamma Linolenic Acid ◽  
Insulin Levels ◽  
Decrease Blood Glucose

scholarly journals An anxiolytic drug buspirone ameliorates hyperglycemia and endothelial dysfunction in type 2 diabetic rat model

2020 ◽  
Vol 45 (4) ◽  
pp. 397-404
Author(s):  
Tugba Gurpinar Çavuşoğlu ◽  
Ertan Darıverenli ◽  
Kamil Vural ◽  
Nuran Ekerbicer ◽  
Cevval Ulman ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Endothelial Dysfunction ◽  
Vascular Function ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Insulin Levels ◽  
Type 2 Diabetic

AbstractObjectivesType 2 diabetes is a common metabolic disease and anxiety disorders are very common among diabetics. Buspirone is used in the treatment of anxiety, also having blood glucose-lowering effects. The aim of the study was to investigate the effects of buspirone on the glucose and lipid metabolism as well as vascular function in type 2 diabetic rats.MethodsA type 2-diabetic model was induced through a high-fat diet for eight weeks followed by the administration of low-dose streptozotocin (35 mg/kg, intraperitoneal) in rats. Buspirone was given at two different doses (1.5 mg/kg/d and 5 mg/kg/d) and combined with metformin (300 mg/kg/d). The fasting glucose and insulin levels, lipid profile were analyzed, and vascular response measured from the thoracic aorta was also evaluated.ResultsBoth doses of buspirone caused a significant improvement in fasting blood glucose levels. In particular, the buspirone treatment, combined with metformin, improved endothelial dysfunction and was found to be correlated with decreased nitrate/nitrite levels.ConclusionsBuspirone may be effective in the treatment of type 2 diabetes, either alone or in combination with other treatments, particularly in terms of endothelial dysfunction, inflammation and impaired blood glucose, and insulin levels.

scholarly journals The Relationship between Dietary Habits, Blood Glucose and Insulin Levels among People without Cardiovascular Disease and Type 2 Diabetes; The ATTICA Study

2005 ◽  
Vol 2 (4) ◽  
pp. 208-208 ◽  
Author(s):  
Demosthenes B. Panagiotakos ◽  
Natalia Tzima ◽  
Christos Pitsavos ◽  
Christina Chrysohoou ◽  
Emilia Papakonstantinou ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Blood Glucose ◽  
Dietary Habits ◽  
Insulin Levels ◽  
The Relationship

Dihomo-gamma-linolenic acid levels and obesity in patients with type 2 diabetes

2014 ◽  
Vol 6 (3) ◽  
pp. 206-211 ◽  
Author(s):  
Kaoru Yamashita ◽  
Mariko Higa ◽  
Rieko Kunishita ◽  
Ken Kanazawa ◽  
Mai Tasaki ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Linolenic Acid ◽  
Gamma Linolenic Acid

scholarly journals PENGARUH RELAKSASI AUTOGENIK TERHADAP KADAR GLUKOSA DARAH PADAPASIEN DIABETES MELITUS TIPE 2

2015 ◽  
Vol 1 (01) ◽  
Author(s):  
Marta Lina Limbong ◽  
Ridha Darma Jaya ◽  
Yesi Ariani
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Control Group ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Decrease Blood Glucose ◽  
Autogenic Relaxation ◽  
Range Test ◽  
Diabetes Melitus

Abstract Patients with type 2 diabetes relative insulin deficiency so that blood glucose regulation becomes screwed, eventually causing hyperglycemia. When it is left untreated can lead to complications. Complications in diabetic patients undergoing indicate hospitalization for management of blood glucose levels. Such conditions often make the patient stress and anxiety experiencing great that ultimately may increase blood glucose levels. Autogenic relaxation is the relaxation that comes from yourself form of words or short sentences or thoughts that can make the mind peaceful. Autogenic relaxation response can divert our bodies consciously by the command of yourself, it can help fight the harmful effects of stress. Autogenic relaxation could be expected to control blood glucose levels. The purpose of this study was to determine the effect of autogenic relaxation on blood glucose levels in patients with Type 2 Diabetes. Research design was quasi-experimental with pre and post with control group, for each sample group consisted of 31 people with consecutive sampling technique. Data were analyzed using univariate and bivariate. The statistical test used the Wilcoxon Sign-Range Test and Mann Whitney U . Analysis showed there is effect of autogenic relaxation to decrease blood glucose levels (p = 0.001). The conclusion of study, there are significant autogenic relaxation to decrease blood glucose levels in patients with diabetes mellitus type 2. Results of this study can be input for nursing services to make the autogenic relaxation womanly one independent nursing interventions in providing nursing care to patients with DM Type 2 Keywords: Autogenic relaxation, blood glucose levels, type 2 diabetes   Abstrak Pasien diabetes melitus tipe 2 relatif mengalami kekurangan insulin sehingga pengaturan kadar glukosa darah menjadi tidak terkontrol, pada akhirnya menyebabkan hiperglikemia. Bilamana hal ini tidak ditangani dapat menyebabkan komplikasi. Komplikasi pada diabetes mengindikasikan pasien menjalani perawatan di rumah sakit untuk pengelolaan kadar glukosa darah. Kondisi seperti ini sering membuat pasien stres dan mengalami kecemasan yang hebat sehingga dapat meningkatkan kadar glukosa darah. Relaksasi autogenik merupakan relaksasi yang bersumber dari diri sendiri berupa kata-kata atau kalimat pendek atau pikiran yang dapat membuat pikiran tentram. Relaksasi autogenik dapat mengalihkan respon tubuh kita secara sadar berdasarkan perintah dari diri sendiri, maka dapat membantu melawan efek stres yang berbahaya. Relaksasi autogenik diduga dapat mengontrol kadar glukosa darah. Tujuan penelitian ini untuk mengetahui pengaruh relaksasi autogenik terhadap penurunan kadar glukosa darah pada pasien DM Tipe 2. Desain penelitian ini kuasi eksperimen dengan pre and post with control group, untuk masing-masing kelompok terdiri 31 orang sampel dengan tehnik  consecutive sampling. Data dianalisis secara univariat dan bivariat. Uji statistik yang digunakan Wilcoxon Sign Range Test dan Mann Whitney U. Hasil analisis menunjukkan ada pengaruh relaksasi autogenik terhadap penurunan kadar glukosa darah (p=0,001). Kesimpulan penelitian ini, ada pengaruh relaksasi autogenik terhadap penurunan kadar glukosa darah pada pasien diabetes melitus tipe 2. Hasil penelitian ini dapat menjadi masukan bagi pelayanan keperawatan untuk menjadikan relaksasi autogenik menjasi salah satu intervensi keperawatan mandiri dalam memberikan asuhan keperawatan pada pasien DM Tipe 2. Kata kunci : Relaksasi autogenik, Kadar glukosa darah, diabetes melitus tipe 2 Full printable version: PDF

scholarly journals Type 2 Diabetes Mellitus: A Pathophysiologic Perspective

2021 ◽  
Vol 8 ◽  
Author(s):  
Eric C. Westman
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Glucose Concentration ◽  
Elevated Blood ◽  
Insulin Levels ◽  
Blood Insulin ◽  
Average Adult

Type 2 Diabetes Mellitus (T2DM) is characterized by chronically elevated blood glucose (hyperglycemia) and elevated blood insulin (hyperinsulinemia). When the blood glucose concentration is 100 milligrams/deciliter the bloodstream of an average adult contains about 5–10 grams of glucose. Carbohydrate-restricted diets have been used effectively to treat obesity and T2DM for over 100 years, and their effectiveness may simply be due to lowering the dietary contribution to glucose and insulin levels, which then leads to improvements in hyperglycemia and hyperinsulinemia. Treatments for T2DM that lead to improvements in glycemic control and reductions in blood insulin levels are sensible based on this pathophysiologic perspective. In this article, a pathophysiological argument for using carbohydrate restriction to treat T2DM will be made.

scholarly journals Impact of β-blocker treatment and nutritional status on glycemic response during exercise in patients with type 2 diabetes

2007 ◽  
Vol 30 (6) ◽  
pp. 257 ◽  
Author(s):  
Annie Ferland ◽  
Patrice Brassard ◽  
Sara Croteau ◽  
Simone Lemieux ◽  
Jean Bergeron ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Hypoglycemic Agents ◽  
Exercise Session ◽  
Insulin Levels ◽  
Fasted State ◽  
Β Blocker ◽  
Β Blockers ◽  
The Impact

Purpose: Most individuals with type 2 diabetes are affected by hypertension and thus have higher risk of cardiac complications. In addition to behavioural modifications, such as healthy food choices and regular physical activity, β-blocker treatment may be considered to reduce morbidity and mortality, especially after a cardiovascular event. However, this medication is generally associated with a deleterious impact on glucose metabolism. The objective of the study was to assess the impact of β-blocker treatment on glucose response during exercise in patients with type 2 diabetes, free of cardiovascular complications. Methods: Ten sedentary men, treated with diet and/or hypoglycemic agents have performed four exercise sessions at 60% of their O2peak, in the fasted state or 2 hours following a standardized breakfast, with and without β-blockers (atenolol 100 mg id for five consecutive days). Blood samples were drawn during the resting period, at 15-min intervals during the exercise session and during the recovery period. Results: A reduction of blood glucose levels was observed following the exercise session in the postprandial state (48% and 44% reduction with and without β-blockers respectively; P < 0.001). One hour of exercise performed in the fasted state had a minimal impact on glucose and insulin levels, whether with or without β-blockers. β-blocker treatment was not associated with increased baseline blood glucose or insulin levels in the fasted or the postprandial situation. Conclusion: Dietary status has a more important impact on plasma glucose and insulin modulation than short-term use of β-blockers.

scholarly journals Bioactive Lipids-Based Approach to Aging Associated Diseases/Disorders

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 17-17
Author(s):  
Undurti Das
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Coronary Heart Disease ◽  
Type 2 Diabetes Mellitus ◽  
Arachidonic Acid ◽  
Heart Disease ◽  
Linolenic Acid ◽  
Gamma Linolenic Acid ◽  
Lipoxin A4

Abstract Objectives To investigate the role of bioactive lipids (BAL) in ageing associated disorders such as obesity, type 2 diabetes mellitus, hypertension, coronary heart disease, immune dysfunction and cancer. Methods We recruited known patients of type 2 diabetes mellitus, hypertension, coronary heart disease, diabetic nephropathy and cancer and collected their blood samples for the study. In these samples the concentrations of various BAL such as linoleic acid, gamma-linolenic acid, dihomo-gamma-linolenic acid, arachidonic acid, alpha-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid and other lipids in their phospholipid fraction was measured. The role of these BAL in these diseases was also studied in animal models of diabetes mellitus and cancer. To evaluate the mechanism of action of BAL, in animal models of type 2 diabetes mellitus and cancer, the expression of NF-kB, IKB, COX-1, COX-2 and LOX and plasma levels of IL-6, TNF, nitric oxide and lipid peroxides was also studied. Results Plasma levels of arachidonic acid in the phospholipid fraction was found to be low in all the patients recruited in the study. In some of these patients plasma levels of gamma-linolenic acid, eicosapentaenic acid and docosahexaenoic acid were also found to be altered. But, of all the lipids estimated, arachidonic acid was found to be consistently low in those with obesity, type 2 diabetes mellitus, hypertension, coronary heart disease and cancer. In animal models of type 2 diabetes mellitus, hypertension and cancer, administration of arachidonic acid produced significant amelioration of these conditions suggesting a critical role for this lipid in these diseases. Further studies revealed that arachidonic acid suppresses inflammation and enhanced the formation of lipoxin A4 (LXA4), which is a potent anti-inflammatory compound. A significant suppression of pro-inflammatory genes and restoration of anti-oxidant status to normal. Conclusions Based on the results of the present study, ageing associated diseases such as obesity, type 2 diabetes mellitus, hypertension, coronary heart disease, and cancer are inflammatory conditions with low circulating concentrations of arachidonic acid and lipoxin A4. These results imply that appropriate administration of arachidonic acid and lipoxin A4 could be of benefit in ageing and ageing associated diseases. Funding Sources Nil.

scholarly journals Brain region specific disruption of mitochondrial bioenergetics in cynomolgus macaques fed a Western vs. a Mediterranean diet

2021 ◽  
Author(s):  
K. Allison Amick ◽  
Gargi Mahapatra ◽  
Jaclyn Bergstrom ◽  
Zhengrong Gao ◽  
Suzanne Craft ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Mediterranean Diet ◽  
Brain Region ◽  
Brain Regions ◽  
Western Diet ◽  
Mitochondrial Bioenergetics ◽  
Insulin Levels ◽  
Cynomolgus Macaques

Mitochondrial dysfunction is evident in diseases affecting cognition and metabolism such as Alzheimer's disease and type 2 diabetes. Human studies of brain mitochondrial function are limited to post-mortem tissue, preventing the assessment of bioenergetics by respirometry. Here, we investigated the effect of two diets on mitochondrial bioenergetics in three brain regions: the prefrontal cortex (PFC), the entorhinal cortex (ERC), and the cerebellum (CB), using middle-aged non-human primates. Eighteen female cynomolgus macaques aged 12.3 ± 0.7 years were fed either a Mediterranean diet that is associated with healthy outcomes or a Western diet that is associated with poor cognitive and metabolic outcomes. Average bioenergetic capacity within each brain region did not differ between diets. Distinct brain regions have different metabolic requirements related to their function and disease susceptibility. Therefore, we also examined differences in bioenergetic capacity between brain regions. Mitochondria isolated from animals fed a Mediterranean diet maintained distinct differences in mitochondrial bioenergetics between brain regions while animals fed the Western diet had diminished distinction in bioenergetics between brain regions. Notably, fatty acid β-oxidation was not affected between regions in animals fed a Western diet. Additionally, bioenergetics in animals fed a Western diet had positive associations with fasting blood glucose and insulin levels in PFC and ERC mitochondria, but not in CB mitochondria. Altogether, these data indicate that a Western diet disrupts bioenergetics across brain regions and that circulating blood glucose and insulin levels in Western diet fed animals influence bioenergetics in brain regions susceptible to Alzheimer's disease and type 2 diabetes.

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