Alternative Therapeutic Approach for the Management of Symptomatic Hyperammonemia Syndrome after Lung Transplantation

2019 ◽  
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Güliz Acker ◽  
Julia Zollfrank ◽  
Claudius Jelgersma ◽  
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2001 ◽  
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pp. 61-62 ◽  
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Maria Pia De Carolis ◽  
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Antonio Gasbarrini ◽  
Giovanni de Francisci ◽  
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2016 ◽  
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Karin Pichler ◽  
Daniela Karall ◽  
Dieter Kotzot ◽  
Elisabeth Steichen-Gersdorf ◽  
Alexandra Rümmele-Waibel ◽  
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2019 ◽  
Vol 3 (2) ◽  
pp. 76
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Shaktypreya Nadarajah ◽  
Nadiah Shidik ◽  
Noorjahan Banu Mohammed Alitheen

Cancer immunotherapy using cytokines has been sought as an alternative therapeutic approach for treating cancers. Besides remarkable immunoregulatory properties, interleukin (IL)-27 has recently been shown to possess promising anticancer functions; hence, its potential roles in cancer immunotherapy. Although proven to be effective against cancer cell growth and angiogenesis, given its dual immune-regulating functions (pro-inflammatory and anti-inflammatory), the use of IL-27 as a cancer immunotherapeutic cytokine could possibly be a two-edged sword without meticulous and thorough research. This mini-review mainly discusses the functions and future prospects of IL-27 as an effective anticancer cytokine. Hopefully, it imparts useful insights into the potential applications of IL-27 in cancer immunotherapy


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