scholarly journals Antifungal lock therapy: an eternal promise or an effective alternative therapeutic approach?

2022 ◽  
Author(s):  
Renátó Kovács ◽  
László Majoros
Keyword(s):  
Therapeutic Approach ◽  
Effective Alternative ◽  
Alternative Therapeutic Approach ◽  
Lock Therapy ◽  
Antifungal Lock Therapy

The CXCR2/CXCL2 signalling pathway – An alternative therapeutic approach in high-grade glioma

2020 ◽  
Vol 126 ◽  
pp. 106-115 ◽  
Author(s):  
Güliz Acker ◽  
Julia Zollfrank ◽  
Claudius Jelgersma ◽  
Melina Nieminen-Kelhä ◽  
Irina Kremenetskaia ◽  
...  
Keyword(s):  
Therapeutic Approach ◽  
High Grade Glioma ◽  
Signalling Pathway ◽  
High Grade ◽  
Alternative Therapeutic Approach

Alternative Therapeutic Approach for the Management of Symptomatic Hyperammonemia Syndrome after Lung Transplantation

2019 ◽  
Vol 38 (4) ◽  
pp. S326
Author(s):  
A.M. Emtiazjoo ◽  
S. Chandrashekaran ◽  
C. Lin ◽  
H. Alnuaimat ◽  
A. Shahmohammadi ◽  
...  
Keyword(s):  
Lung Transplantation ◽  
Therapeutic Approach ◽  
Alternative Therapeutic Approach

Caudal blockade as alternative therapeutic approach in neonatal arterial thrombosis

2001 ◽  
Vol 160 (1) ◽  
pp. 61-62 ◽  
Author(s):  
Maria Pia De Carolis ◽  
Costantino Romagnoli ◽  
Antonio Gasbarrini ◽  
Giovanni de Francisci ◽  
Fiammetta Piersigilli ◽  
...  
Keyword(s):  
Arterial Thrombosis ◽  
Therapeutic Approach ◽  
Alternative Therapeutic Approach ◽  
Caudal Blockade

scholarly journals Bisphosphonates in multicentric osteolysis, nodulosis and arthropathy (MONA) spectrum disorder – an alternative therapeutic approach

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Karin Pichler ◽  
Daniela Karall ◽  
Dieter Kotzot ◽  
Elisabeth Steichen-Gersdorf ◽  
Alexandra Rümmele-Waibel ◽  
...  
Keyword(s):  
Therapeutic Approach ◽  
Spectrum Disorder ◽  
Alternative Therapeutic Approach

scholarly journals Rabbit Model of Candida albicans Biofilm Infection: Liposomal Amphotericin B Antifungal Lock Therapy

2004 ◽  
Vol 48 (5) ◽  
pp. 1727-1732 ◽  
Author(s):  
Matthew K. Schinabeck ◽  
Lisa A. Long ◽  
Mohammad A. Hossain ◽  
Jyotsna Chandra ◽  
Pranab K. Mukherjee ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Amphotericin B ◽  
Treatment Strategy ◽  
Liposomal Amphotericin ◽  
Rabbit Model ◽  
Liposomal Amphotericin B ◽  
Electron Microscopic ◽  
Lock Therapy ◽  
Antifungal Lock Therapy ◽  
Scanning Electron

ABSTRACT Catheter-related infections due to Candida albicans biofilms are a leading cause of fungal nosocomial bloodstream infection. In this paper, we describe the development of a model of catheter-associated infection with C. albicans biofilms and show that antifungal lock therapy with liposomal amphotericin B is an effective treatment strategy for these infections. Silicone catheters surgically placed in New Zealand White rabbits were infected with C. albicans, and the rabbits were randomized into three groups: (i) untreated controls, (ii) liposomal amphotericin B lock, and (iii) fluconazole lock. Upon completion of therapy, blood cultures were obtained and the catheters were removed for quantitative culture and scanning electron microscopic analyses. Quantitative cultures revealed that catheters treated with liposomal amphotericin B yielded 0 CFU, which was significant compared to the untreated controls (P < 0.001) and the fluconazole-treated group (P = 0.0079). Although fluconazole treatment tended to have lower CFU compared to untreated controls, there was no difference in mean colony counts between these two groups (1.128 ± 0.764 and 1.841 ± 1.141 log10 CFU/catheter segment, respectively; P = 0.297). Scanning electron microscopy revealed abundant biofilm in the control and fluconazole groups, while the liposomal amphotericin B group was virtually cleared. These findings suggest a possible treatment strategy for the successful salvage of catheters infected with C. albicans biofilms and describe an animal model that may play an important role in the further study of C. albicans biofilm pathogenesis and evaluation of potential antibiofilm agents.

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