Entrepreneurship is a strategic opportunity for human development, on which MNCs play a vital role in the spillover effect. This chapter aims (1) to illustrate corporate social entrepreneurship (CSE) practices to generate social value and (2) to explore their ethical constraint alleviation. Using an internet-mediated research, a sustainability analysis of seventy companies from different countries and sizes evidenced that CSE is a tool for economic growth and good governance. This study brings new insights to the field of CSR and its role in sustainability by incorporating the entrepreneurship discipline. A corporate social innovation business model is proposed as a core business strategy. Also, Ecuadorian CSE practices and their different perspectives can serve as references for future studies.