A promising wound dressing material with excellent cytocompatibility and proangiogenesis action for wound healing: Strontium loaded Silk fibroin/Sodium alginate (SF/SA) blend films

2017 ◽  
Vol 104 ◽  
pp. 969-978 ◽  
Author(s):  
Shuangshuang Li ◽  
Li Li ◽  
Chengrui Guo ◽  
Huanhuan Qin ◽  
Xixun Yu
Keyword(s):  
Wound Healing ◽  
Sodium Alginate ◽  
Silk Fibroin ◽  
Wound Dressing ◽  
Blend Films

Histological evaluation of wound healing performance of electrospun poly(vinyl alcohol)/sodium alginate as wound dressing in vivo

2014 ◽  
Vol 24 (2) ◽  
pp. 1527-1536 ◽  
Author(s):  
Gökçe Coşkun ◽  
Esra Karaca ◽  
Mustafa Ozyurtlu ◽  
Serhat Özbek ◽  
Aysun Yermezler ◽  
...  
Keyword(s):  
Wound Healing ◽  
Sodium Alginate ◽  
Vinyl Alcohol ◽  
Wound Dressing ◽  
Histological Evaluation ◽  
Poly Vinyl Alcohol

Silk Fibroin/Sodium Alginate Composite Film and Hydroxyapatite Mineralization

2014 ◽  
Vol 787 ◽  
pp. 460-467 ◽  
Author(s):  
Jin Fa Ming ◽  
Xiao Xiao Yue ◽  
Feng Zhang ◽  
Yao Xing Jiang ◽  
Bao Qi Zuo
Keyword(s):  
Fourier Transform ◽  
Sodium Alginate ◽  
Silk Fibroin ◽  
Average Length ◽  
Fourier Transform Infrared ◽  
Infrared Analysis ◽  
Wide Angle ◽  
X Ray Diffraction ◽  
X Ray ◽  
Blend Films

Silk fibroin/sodium alginate blend films and its hydroxyapatite deposition were prepared and characterized by scanning electron microscopy, wide angle X-ray diffraction, Fourier transform infrared analysis, and thermal analysis. The surface of blend films showed much more rod-like structure dispersing uniformity and its average length increasing from 181 to 803nm with increasing the contents of sodium alginate. The crystal structure of silk fibroin and the compatibility of the two components were associated with the content of sodium alginate in silk fibroin/sodium alginate blend films. The silk I and silk II crystal structures of silk fibroin were co-existed in the blend films and a rather complex conformation transition occurred, which was confirmed by wide angle X-ray diffraction and Fourier transform infrared analysis. Thermal behavior of blend films was interrupted by adding different contents of sodium alginate. Adding 30.0% sodium alginate or more, the endothermic peak of moisture evaporation shifted downward from 111 to 80°C, and the degradation peaks at 243 and 279°C, respectively, indicating an obviously two phase structure in the blend films. In addition, the rod-like HAp crystals were grown on the surface of blend films. This result may provide some new ideas in the design and fabrication of new materials through the silk fibroin/sodium alginate composite materials template for the hydroxyapatite crystal growth.

Preparation and Characterization of Silk Fibroin Based Antibacterial Biotextiles as Wound Dressing

2017 ◽  
Vol 898 ◽  
pp. 2095-2100 ◽  
Author(s):  
Zhi Hua Lu ◽  
Dong Mei Zhao ◽  
Cheng Shun Li
Keyword(s):  
Thin Film ◽  
Wound Healing ◽  
Porous Structure ◽  
Silk Fibroin ◽  
Wound Dressing ◽  
Antibacterial Property ◽  
Chitosan Solution ◽  
Skin Regeneration ◽  
Sem Micrographs

A novel silk fibroin (SF) based bi-layered wound dressing was successfully developed by spraying chitosan (CS) solution on the ring spun silk fibroin fabric. SEM micrographs showed that chitosan solution formed a thin film on the degummed silk fibroin fabric, which had a connective porous structure. The antibacterial property, indirect cytotoxicity and the wound healing properties of the materials were investigated. Comparing with the commercial wound dressing, the bi-layered SF/CS wound dressing could accelerate the wound healing, and may be a potential choice for skin regeneration.

Early nursing care of peritoneal dialysis catheter outlet with multi-functional nanogel of antibacterial and healing

2021 ◽  
Vol 11 (8) ◽  
pp. 1412-1419
Author(s):  
Haiyan Liu ◽  
Shenyi Liu ◽  
Xinying Dong
Keyword(s):  
Wound Healing ◽  
Peritoneal Dialysis ◽  
Wound Infection ◽  
Clinical Application ◽  
Silk Fibroin ◽  
Nursing Care ◽  
Wound Dressing ◽  
Secondary Trauma ◽  
Peritoneal Dialysis Catheter ◽  
Dialysis Catheter

Infection at the outlet of the catheter in peritoneal dialysis (PD) is one of the leading causes of peritonitis, as well as the main cause of catheter extraction and patient mortality. The use of dressings at the outlet of the catheter is important to prevent secondary trauma and wound infection. This study reports the development of a multifunctional hydrogel dressing with antibacterial, repair, and anti-infection functionality: the dextran–curcumin silk fibroin (Dex-Cur@SF) hydrogel dressing. Clinical application demonstrated that compared with standard wound dressing, Dex-Cur@SF hydrogel dressing had stronger antibacterial, anti-infection, and analgesic properties, reduced the interval of dressing changes, and promoted wound healing. These results suggest that Dex-Cur@SF may represent an improved option for nursing care at the outlet of PD catheters.

The effect of a new wound dressing on wound healing: Biochemical and histopathological evaluation

Burns ◽  
2020 ◽  
Vol 46 (1) ◽  
pp. 143-155 ◽  
Author(s):  
Serdar Tort ◽  
Fatmanur Tuğcu Demiröz ◽  
Şule Coşkun Cevher ◽  
Sanem Sarıbaş ◽  
Candan Özoğul ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Histopathological Evaluation

scholarly journals Fabrication of Hybrid Nanofibers from Biopolymers and Poly (Vinyl Alcohol)/Poly (ε-Caprolactone) for Wound Dressing Applications

Polymers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 2104
Author(s):  
Sibusiso Alven ◽  
Blessing Atim Aderibigbe
Keyword(s):  
Mechanical Properties ◽  
Wound Healing ◽  
Vinyl Alcohol ◽  
Wound Dressing ◽  
Chronic Wounds ◽  
Cellular Adhesion ◽  
Wound Dressings ◽  
Poly Vinyl Alcohol ◽  
High Porosity ◽  
Hybrid Nanofibers

The management of chronic wounds is challenging. The factors that impede wound healing include malnutrition, diseases (such as diabetes, cancer), and bacterial infection. Most of the presently utilized wound dressing materials suffer from severe limitations, including poor antibacterial and mechanical properties. Wound dressings formulated from the combination of biopolymers and synthetic polymers (i.e., poly (vinyl alcohol) or poly (ε-caprolactone) display interesting properties, including good biocompatibility, improved biodegradation, good mechanical properties and antimicrobial effects, promote tissue regeneration, etc. Formulation of these wound dressings via electrospinning technique is cost-effective, useful for uniform and continuous nanofibers with controllable pore structure, high porosity, excellent swelling capacity, good gaseous exchange, excellent cellular adhesion, and show a good capability to provide moisture and warmth environment for the accelerated wound healing process. Based on the above-mentioned outstanding properties of nanofibers and the unique properties of hybrid wound dressings prepared from poly (vinyl alcohol) and poly (ε-caprolactone), this review reports the in vitro and in vivo outcomes of the reported hybrid nanofibers.

scholarly journals Sustained Release of Insulin-Like Growth Factor-1 from Bombyx mori L. Silk Fibroin Delivery for Diabetic Wound Therapy

2021 ◽  
Vol 22 (12) ◽  
pp. 6267
Author(s):  
Meng-Jin Lin ◽  
Mei-Chun Lu ◽  
Hwan-You Chang
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Sustained Release ◽  
Silk Fibroin ◽  
Granulation Tissue ◽  
Release Rate ◽  
Insulin Like Growth Factor ◽  
Diabetic Wound ◽  
Diabetic Mice ◽  
Wound Therapy

The goals of this study are to develop a high purity patented silk fibroin (SF) film and test its suitability to be used as a slow-release delivery for insulin-like growth factor-1 (IGF-1). The release rate of the SF film delivering IGF-1 followed zero-order kinetics as determined via the Ritger and Peppas equation. The release rate constant was identified as 0.11, 0.23, and 0.09% h−1 at 37 °C for SF films loaded with 0.65, 6.5, and 65 pmol IGF-1, respectively. More importantly, the IGF-1 activity was preserved for more than 30 days when complexed with the SF film. We show that the IGF-1-loaded SF films significantly accelerated wound healing in vitro (BALB/3T3) and in vivo (diabetic mice), compared with wounds treated with free IGF-1 and an IGF-1-loaded hydrocolloid dressing. This was evidenced by a six-fold increase in the granulation tissue area in the IGF-1-loaded SF film treatment group compared to that of the PBS control group. Western blotting analysis also demonstrated that IGF-1 receptor (IGF1R) phosphorylation in diabetic wounds increased more significantly in the IGF-1-loaded SF films group than in other experimental groups. Our results suggest that IGF-1 sustained release from SF films promotes wound healing through continuously activating the IGF1R pathway, leading to the enhancement of both wound re-epithelialization and granulation tissue formation in diabetic mice. Collectively, these data indicate that SF films have considerable potential to be used as a wound dressing material for long-term IGF-1 delivery for diabetic wound therapy.

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