Enhancement of laccase production from a newly isolated Trichoderma harzianum S7113 using submerged fermentation: Optimization of production medium via central composite design and its application for hydroquinone degradation

2021 ◽  
Author(s):  
Abdelmageed M. Othman ◽  
Mohamed Mahmoud ◽  
Mohamed Abdelraof ◽  
Ghada S.A. Abdel Karim ◽  
Alshaimaa M. Elsayed
Keyword(s):  
Central Composite Design ◽  
Trichoderma Harzianum ◽  
Submerged Fermentation ◽  
Fermentation Optimization ◽  
Laccase Production ◽  
Production Medium ◽  
Central Composite

Optimization of the Submerged Fermentation Conditions of Ganoderma Lucidum with High Triterpenoids Production by Response Surface Analysis

2012 ◽  
Vol 621 ◽  
pp. 259-262
Author(s):  
Mei Lin Cui ◽  
Guo Qing He
Keyword(s):  
Regression Model ◽  
Central Composite Design ◽  
Yeast Extract ◽  
Submerged Fermentation ◽  
Ganoderma Lucidum ◽  
Fermentation Conditions ◽  
Independent Variables ◽  
Extract Concentration ◽  
Set Up ◽  
Central Composite

In this paper, yeast extract concentration, incubation days and inoculation was made as independent variables, the production of intracellular triterpenoids, intracellular polysaccharides and mycelia biomass were made as response values, we set up central composite design of three factors and three levels. Through the analysis of the regression model, we could see that when yeast extract concentration was 1.91%, the inoculation was 14.99% and the incubation days was 4.24d, the production of intracellular triterpenoids, intracellular polysaccharides and mycelia biomass was 100.654 mg/100ml, 58.5968 mg/100ml, 2.39258 g/100ml, respectively.

Development and optimization of solid lipid nanoparticles of amikacin by central composite design

2009 ◽  
Vol 00 (00) ◽  
pp. 090721051030036-8
Author(s):  
Jaleh Varshosaz ◽  
Solmaz Ghaffari ◽  
Mohammad Reza Khoshayand ◽  
Fatemeh Atyabi ◽  
Shirzad Azarmi ◽  
...  
Keyword(s):  
Central Composite Design ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Central Composite

Formulation Design and Optimization of Repaglinide Solid Dispersions by Central Composite Design

2018 ◽  
Vol 11 (6) ◽  
pp. 4337-4348
Author(s):  
Bhikshapathi D. V. R. N. ◽  
Srinivas I
Keyword(s):  
Central Composite Design ◽  
Dissolution Rate ◽  
Solid Dispersion ◽  
Solid Dispersions ◽  
Solvent Evaporation ◽  
Release Mechanism ◽  
Solvent Evaporation Method ◽  
Onset Of Action ◽  
Evaporation Method ◽  
Central Composite

Repaglinide is a pharmaceutical drug used for the treatment of type II diabetes mellitus, it is characterized with poor solubility which limits its absorption and dissolution rate and delays onset of action. In the present study, immediate release solid dispersion of repaglinide was formulated by solvent evaporation technique. Repaglinide solid dispersions were prepared using PEG 8000, Pluronic F 127 and Gelucire 44/14 by solvent evaporation method. A 3-factor, 3-level central composite design employed to study the effect of each independent variable on dependent variables. FTIR studies revealed that no drug excipient interaction takes place. From powder X-ray diffraction (p-XRD) and by scanning electron microscopy (SEM) studies it was evident that polymorphic form of repaglinide has been converted into an amorphous form from crystalline within the solid dispersion formulation. The correlation coefficient showed that the release profile followed Higuchi model anomalous behavior and hence release mechanism was indicative of diffusion. The obtained results suggested that developed solid dispersion by solvent evaporation method might be an efficacious approach for enhancing the solubility and dissolution rate of repaglinide.

Formulation and Optimization of 5-Fluorouracil Loaded Chitosan Nanoparticles Employing Central Composite Design

2012 ◽  
Vol 2 (4) ◽  
pp. 281-289
Author(s):  
Rattan Lal ◽  
Rakesh Kumar Marwaha ◽  
Deepti Pandita ◽  
Harish Dureja
Keyword(s):  
Central Composite Design ◽  
Chitosan Nanoparticles ◽  
Central Composite
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