Identification of Lumpy skin disease (LSD): First-time in Bangladesh during the investigation of unknown skin disease of cattle

Samples collected for PCR from recipient animals tested positive in 5 out of 6 cases, while the virus was isolated from 4 of 6 animals. The clinical signs exhibited by recipient animals were mostly moderate in nature with only one severe case. To our knowledge, this is the first time that transmission of LSDV by three Stomoxys species has been demonstrated, and their role as mechanical vectors of LSDV is indicated.

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Space-time permutation model applied to the past outbreak data of lumpy skin disease in the Balkan Peninsula from august 2015 to july 2017

Veterinarski glasnik ◽

10.2298/vetgl171027003s ◽

2018 ◽

Vol 72 (1) ◽

pp. 44-55

Author(s):

Zharko Stojmanovski

Keyword(s):

Skin Disease ◽

Balkan Peninsula ◽

Space Time ◽

Scan Statistic ◽

Lumpy Skin Disease ◽

Serbia And Montenegro ◽

Disease Clusters ◽

Risk Areas ◽

Permutation Model ◽

First Time

Introduction: In August 2015, lumpy skin disease (LSD) was notified for the first time in mainland European Union when it was observed in cattle in Greece. From August 2015 to July 2017, 1,757 outbreaks were reported in cattle in Greece, Bulgaria, Macedonia, Albania, Serbia, and Montenegro. Materials and Methods: The Kulldorff space-time permutation scan statistic contained in the software package SaTScan v 9.4.4 was used to analyse the epizootic past outbreak data and describe the spread of the disease in the 24 months after the first notification. Results and Conclusions:: Seventy-six space-time disease clusters (62 significant and 14 non-significant) were identified. In 2015, 10 clusters with a monthly peak in October (n=5, 50%) were identified, in 2016, the most (n=57) clusters were detected with monthly peak in July (n=15, 26.3%), and up to July 2017, nine clusters with a monthly peak in May (n=3, 3.3%) were determined. Possible high-risk areas were identified using the presented methodology, and so this technique could guide national veterinary authorities to formulate strategies for mitigating the spread of LSD, allocating resources and for formulating epidemiological preparedness plans in neighbouring, LSD-negative, countries.

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Outbreak investigation of lumpy skin disease in dairy farms at Barishal, Bangladesh

Turkish Journal of Agriculture - Food Science and Technology ◽

10.24925/turjaf.v9i1.205-209.3827 ◽

2021 ◽

Vol 9 (1) ◽

pp. 205-209

Author(s):

Md. Ibrahim Khalil ◽

Mohammad Ferdous Rahman Sarker ◽

F. M. Yasir Hasib ◽

Sharmin Chowdhury

Keyword(s):

Skin Disease ◽

Dairy Farms ◽

Effective Control ◽

Morbidity Rate ◽

Crossbred Cattle ◽

Lumpy Skin Disease ◽

Cattle Disease ◽

Outbreak Area ◽

Steroid Drugs ◽

First Time

Lumpy skin disease is explained as a significant cattle disease affecting cattle of many parts of the world. An outbreak was experienced in different parts of Bangladesh including Barishal for the first time in the last quarter of 2019. This investigation was carried out to know the outbreak scenario of the disease in southern part of Bangladesh. A total of 726 cattle were included in this study covering 50 dairy farms of Barishal region from September 2019 to December 2019. Morbidity rate was found 21% (CI: 18-24%) and mortality was 1% (CI: 1-2%) in the outbreak area. Young animals (24%) and pregnant animals (70%) were significantly more susceptible compared to aged animals (17%) and non-pregnant animals (15%), respectively. Moreover, male and crossbred cattle were slightly more prone to the infection in comparison to their counterparts. About 45% of the affected animals showed nodular and remaining 55% had edematous lesions. Almost 90% of the affected animals were treated with NSAID followed by antibiotics, antihistaminic, steroid drugs and antiviral drugs where only 20% of the affected animals were treated by authorized veterinary personnel. This was the first epidemiological investigation in the mentioned outbreak area which may serve as a baseline for LSD research in the location needed for developing effective control strategy.

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Isolation and molecular identification of Lumpy Skin Disease (LSD) virus from infected cattle in Bangladesh

Bangladesh Journal of Livestock Research ◽

10.3329/bjlr.v26i1-2.49933 ◽

2020 ◽

Vol 26 (1-2) ◽

pp. 15-20

Author(s):

M Giasuddin ◽

MA Yousuf ◽

M Hasan ◽

MH Rahman ◽

MZ Hassan ◽

...

Keyword(s):

Skin Disease ◽

Infected Animal ◽

Economic Losses ◽

Infected Cattle ◽

Lumpy Skin Disease ◽

Cattle Disease ◽

Nodular Lesions ◽

The Many ◽

First Time ◽

Ocular Discharge

Lumpy Skin Disease (LSD) is a new disease of cattle in Bangladesh. It is endemic in Africa but through the last few years disease beings to spread to other countries of the world. The disease was widely spreaded in the many other countries in Asia and some parts of Europe. In Bangladesh, the disease was first time detected in April 2019, in southern part and then continued to spread all over the country.The disease caused enormous economic losses causing cutaneous and internal lesions, affecting milk production, hide quality and in some cases death of infected animal. LSD suspected samples were collected from different areas of the country during the period from July 2019 to January 2020. In this study, a total of 36 clinically suspected LSD samples of skin crustnodules, pus and ocular discharge were collected. Samples were examined by the published PCR protocol for LSD virus, GPV and SPV. Around 78% samples were found positive for LSD virus in PCR test. LSD virus was also identified from pus and ocular discharge of infected cattle. The virus can grow in the lamb testicular cell and clinically the disease is characterized by distinctive nodular lesions mostly on the skin of the affected animals.The results indicated that the LSD virus is circulating in the outbreak are as and is an emerging transboundary cattle disease in Bangladesh. Bang. J. Livs. Res. Vol. 26 (1&2), 2019: P. 15-20

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Outbreaks of Lumpy Skin Disease of Cattle in Bangladesh: What to Know and What to Do

SSRN Electronic Journal ◽

10.2139/ssrn.3613498 ◽

2020 ◽

Author(s):

Md. Sahidur Rahman

Keyword(s):

Skin Disease ◽

Lumpy Skin Disease

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MOLECULAR CHARACTERIZATION OF LUMPY SKIN DISEASE VIURS IN CATTLE (2017).

Egyptian Journal of Animal Health ◽

10.21608/ejah.2021.129459 ◽

2021 ◽

Vol 1 (1) ◽

pp. 1-19

Author(s):

Hala Salem

Keyword(s):

Molecular Characterization ◽

Skin Disease ◽

Lumpy Skin Disease

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Comparative Evaluation of Lumpy Skin Disease Virus-Based Live Attenuated Vaccines

Vaccines ◽

10.3390/vaccines9050473 ◽

2021 ◽

Vol 9 (5) ◽

pp. 473

Author(s):

Andy Haegeman ◽

Ilse De Leeuw ◽

Laurent Mostin ◽

Willem Van Campe ◽

Laetitia Aerts ◽

...

Keyword(s):

Disease Virus ◽

Skin Disease ◽

Vaccination Campaign ◽

Ease Of Use ◽

Vaccine Failure ◽

Lumpy Skin Disease ◽

Lumpy Skin Disease Virus ◽

The Balkans ◽

The Past ◽

Preventative Strategy

Vaccines form the cornerstone of any control, eradication and preventative strategy and this is no different for lumpy skin disease. However, the usefulness of a vaccine is determined by a multiplicity of factors which include stability, efficiency, safety and ease of use, to name a few. Although the vaccination campaign in the Balkans against lumpy skin disease virus (LSDV) was successful and has been implemented with success in the past in other countries, data of vaccine failure have also been reported. It was therefore the purpose of this study to compare five homologous live attenuated LSDV vaccines (LSDV LAV) in a standardized setting. All five LSDV LAVs studied were able to protect against a challenge with virulent LSDV. Aside from small differences in serological responses, important differences were seen in side effects such as a local reaction and a Neethling response upon vaccination between the analyzed vaccines. These observations can have important implications in the applicability in the field for some of these LSDV LAVs.

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Development of a Safe and Highly Efficient Inactivated Vaccine Candidate against Lumpy Skin Disease Virus

Vaccines ◽

10.3390/vaccines9010004 ◽

2020 ◽

Vol 9 (1) ◽

pp. 4

Author(s):

Janika Wolff ◽

Tom Moritz ◽

Kore Schlottau ◽

Donata Hoffmann ◽

Martin Beer ◽

...

Keyword(s):

Skin Disease ◽

Animal Health ◽

Vaccine Virus ◽

Lumpy Skin Disease ◽

Virus Shedding ◽

Clinical Protection ◽

Inactivated Vaccines ◽

Disease Free ◽

World Organisation ◽

Free Status

Capripox virus (CaPV)-induced diseases (lumpy skin disease, sheeppox, goatpox) are described as the most serious pox diseases of livestock animals, and therefore are listed as notifiable diseases under guidelines of the World Organisation for Animal Health (OIE). Until now, only live-attenuated vaccines are commercially available for the control of CaPV. Due to numerous potential problems after vaccination (e.g., loss of the disease-free status of the respective country, the possibility of vaccine virus shedding and transmission as well as the risk of recombination with field strains during natural outbreaks), the use of these vaccines must be considered carefully and is not recommended in CaPV-free countries. Therefore, innocuous and efficacious inactivated vaccines against CaPV would provide a great tool for control of these diseases. Unfortunately, most inactivated Capripox vaccines were reported as insufficient and protection seemed to be only short-lived. Nevertheless, a few studies dealing with inactivated vaccines against CaPV are published, giving evidence for good clinical protection against CaPV-infections. In our studies, a low molecular weight copolymer-adjuvanted vaccine formulation was able to induce sterile immunity in the respective animals after severe challenge infection. Our findings strongly support the possibility of useful inactivated vaccines against CaPV-infections, and indicate a marked impact of the chosen adjuvant for the level of protection.

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