ABO blood group as a risk factor for tuberculosis: A network meta-analysis

ABO blood group has a profound influence on hemostasis as it is a major determinant of plasma levels of von Willebrand Factor. In vitro studies suggest that blood group O is a risk factor for increased severe bleeding while blood group non-O is a risk factor for thromboembolic events. Yet, the impact of ABO blood group outcome after multiple trauma is unknown. Retrospective multicenter case-control study from three level-1 trauma centers in Germany from 2012-2015. Inclusion criteria were severe trauma with an Injury severity score ≥9 and admission to an intensive care unit. 1281 patients (69.5% male) were included. Mean Injury Severity Score (ISS) was 21.1±12.4; mean age was 50.2±22.4 years. Distribution of blood groups was: O: 37.4%; A: 44%, B: 12.7 and AB: 5.8%. Hospital mortality depending on blood group was 9.7 (A), 10.4 (B), 6.8 (AB) and 12.7 (O) %. Multivariant logistic regression for mortality revealed an Odds ratio of 0.79 (A), 0.60 (B) and 0.54 (AB) without statistical significance (P=0.35 (A), 0.17 (B), 0.33 (AB)). Thromboembolic events (blood group O vs. others) occurred in 2.8 (O) vs. 3.3 (others) %, P=0.619. In this retrospective study on 1281 multiple injured patients, no relevant influence of ABO blood group on hemorrhage, thromboembolic events and mortality could be found.

Download Full-text

Effect of ABO blood group on asymptomatic, uncomplicated and placental Plasmodium falciparum infection: systematic review and meta-analysis

BMC Infectious Diseases ◽

10.1186/s12879-019-3730-z ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 5

Author(s):

Abraham Degarege ◽

Merhawi T. Gebrezgi ◽

Consuelo M. Beck-Sague ◽

Mats Wahlgren ◽

Luiz Carlos de Mattos ◽

...

Keyword(s):

Systematic Review ◽

Plasmodium Falciparum ◽

Blood Group ◽

Meta Analysis ◽

Falciparum Infection ◽

Abo Blood Group ◽

Plasmodium Falciparum Infection

Download Full-text

ABO blood group as a potential risk factor for venous thromboembolism in acutely injured patients

Thrombosis and Haemostasis ◽

10.1160/th10-08-0504 ◽

2011 ◽

Vol 105 (01) ◽

pp. 5-13 ◽

Cited By ~ 11

Author(s):

Sarah Muellner ◽

Elliott Haut ◽

Michael Streiff ◽

John Holcomb ◽

Bryan Cotton

Keyword(s):

Risk Factor ◽

Venous Thromboembolism ◽

Blood Group ◽

Abo Blood Group ◽

Trauma Patients ◽

Major Health Problem ◽

Increase Risk ◽

Significant Burden ◽

Injured Patients ◽

Von Willebrand

SummaryVenous thromboembolism (VTE) is a major health problem that results in a significant burden on hospitals and patients. VTE screening and prophylaxis protocols in trauma patients vary significantly among hospitals and providers. In addition, many patients develop VTE even in the absence of “high-risk” categories. Therefore, more research is needed to better understand and prevent VTE in these patients. ABO blood group has long been recognised as a risk factor for VTE, but its contribution to VTE risk in the trauma setting is poorly studied. This paper reviews the literature describing the link between ABO blood group and VTE risk and the implications for VTE screening and prophylaxis in trauma patients. The effect of ABO blood groups are genotype-dependent – in most populations the A1 allele and the B allele increase risk while A2, O1, and O2 decrease risk of VTE. ABO group is a major determinant of plasma von Willebrand factor (vWF) and factor VIII levels, thereby (partially) mediating the effects of ABO blood group on VTE susceptibility. In addition, ABH antigens alter plasma levels of vWF via clearance mechanisms, which are in turn mediated by ADAMTS13. ABO blood group is a risk factor for VTE that warrants further investigation in trauma patients.

Download Full-text

ABO blood group and esophageal carcinoma risk: from a case–control study in Chinese population to meta-analysis

Cancer Causes & Control ◽

10.1007/s10552-014-0442-y ◽

2014 ◽

Vol 25 (10) ◽

pp. 1369-1377 ◽

Cited By ~ 9

Author(s):

Wei Wang ◽

Lei Liu ◽

Zhiwei Wang ◽

Xiaopeng Lu ◽

Min Wei ◽

...

Keyword(s):

Esophageal Carcinoma ◽

Blood Group ◽

Chinese Population ◽

Case Control Study ◽

Meta Analysis ◽

Case Control ◽

Abo Blood Group ◽

Carcinoma Risk ◽

Control Study

Download Full-text

Association of ABO blood group with severe falciparum malaria in adults: case control study and meta-analysis

Malaria Journal ◽

10.1186/1475-2875-10-309 ◽

2011 ◽

Vol 10 (1) ◽

pp. 309 ◽

Cited By ~ 39

Author(s):

Aditya K Panda ◽

Santosh K Panda ◽

Aditya N Sahu ◽

Rina Tripathy ◽

Balachandran Ravindran ◽

...

Keyword(s):

Falciparum Malaria ◽

Blood Group ◽

Case Control Study ◽

Meta Analysis ◽

Case Control ◽

Abo Blood Group ◽

Severe Falciparum Malaria ◽

Control Study

Download Full-text

Relationship between ABO blood group and breast cancer at AL-Nassyria city / Iraq

10.32792/thi/sc/vol.1.is.1.04 ◽

2008 ◽

pp. 26-29

Keyword(s):

Breast Cancer ◽

Risk Factor ◽

Cancer Patients ◽

Blood Group ◽

High Frequency ◽

Blood Groups ◽

Blood Type ◽

Abo Blood Group ◽

Abo Blood Groups ◽

Control Samples

The current study included 200 patients with breast cancer that resemble to patient samples were collected from AL-Nassyria hospital also 279 samples as control which was collected from blood bank at ALNassiryia province . The study attempted to correlate ABO blood group with incidence to breast cancer .The results shown that type A of ABO blood group high frequency then followed by type O with in AL-Nassyria region also the results reported that A, B, O and AB blood groups frequencies of patient samples percentage were 60%, 20%, 10% and 10% respectively as well as the ABO blood groups frequencies of control samples percentage were 26%, 28%,38% and 8% respectively. The results observed there is high significant differences between ABO blood group frequencies of cancer patients and ABO blood group frequencies of control samples .The results indicated that the blood type should be considered one of risk factor as well as regarded as preclinical marker.

Download Full-text

The Association Between ABO Blood Group and Preeclampsia: A Systematic Review and Meta-Analysis

Frontiers in Cardiovascular Medicine ◽

10.3389/fcvm.2021.665069 ◽

2021 ◽

Vol 8 ◽

Author(s):

Ting Li ◽

Yixiao Wang ◽

Lan Wu ◽

Zhonghui Ling ◽

Chanjuan Li ◽

...

Keyword(s):

Systematic Review ◽

Regression Analysis ◽

Blood Group ◽

Meta Analysis ◽

Blood Groups ◽

Abo Blood Group ◽

Linear Regression Equation ◽

Funnel Plot ◽

Meta Regression ◽

Meta Regression Analysis

Objective: This meta-analysis comprehensively evaluated the association between ABO blood group and the risk of preeclampsia (PE).Design: Systematic review and meta-analysis.Data sources: PubMed, Web of Science, and ScienceDirect databases from their inception to September 23, 2020.Methods: Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were obtained through random-effects and fixed-effects models according to heterogeneity. Meta-regression analysis was applied to explore the source of heterogeneity. We conducted a subgroup analysis by the publication year, study design, state, and Newcastle-Ottawa Scale (NOS) score. In addition, we calculated the rate of each ABO blood group in PE by total pooled effects.Results: A total of 12 articles with 714,153 patients were included in our analysis. Compared with people without PE (control group), the O blood group presented a lower risk of PE (OR 0.95, 95% CI 0.93–0.97). The AB (OR 1.46, 95% CI 1.12–1.91) blood group presented a higher risk. However, the total pooled OR and 95% CI for the A (OR 1.02, 95% CI 0.90–1.16) and B (OR 1.02, 95% CI 0.98–1.05) blood groups were not significant. The funnel plot and linear regression equation showed that there was no publication bias for the O, A, or B blood groups (all P > 0.05). However, the funnel plot and linear regression equation for the AB blood group were obviously asymmetric (P < 0.05), and the publication bias persisted even after the trim-and-fill method was applied (P < 0.05). Multivariable meta-regression analysis did not find a specific source of heterogeneity. The A blood group showed an association with early-onset PE (OR 0.53, 95% CI 0.33–0.83), and the other blood groups showed no significant differences. In PE, the rates of the O, A, B, and AB blood groups decreased gradually (0.39, 0.33, 0.19, 0.07).Conclusion: These findings suggest that pregnant women with AB blood group are more likely to develop PE, and more attention should be paid to AB blood group whose blood pressure is high but not sufficient to diagnose PE.Systematic Review Registration: Prospero CRD42021227930.

Download Full-text