Proteinuria in Hantavirus Cardiopulmonary Syndrome: a frequent finding linked to mortality

Anemia is considered a common finding in dogs with chronic kidney disease (CKD), typically as normochromic, normocytic, and non-regenerative. Although anemia can occur at any CKD IRIS (International Renal Interest Society) stage, its severity is related with the loss of kidney function. The aim of the present study was to retrospectively evaluate quantitative and morphological abnormalities of the erythrogram in dogs at different CKD IRIS stages. A total of 482 CBCs from 3648 initially screened were included in the study. Anemia was present in 302/482 (63%) dogs, in the majority of which it was normochromic, normocytic, and non-regenerative (295/302; 98%). The number of reticulocytes was <60,000/μL in the majority of dogs (248/295; 84%), with a correlation between poor regeneration rate and progression of CKD (p = 0.0001). The frequency of anemia significantly differed (p = 0.0001) among the IRIS stages: 108/231 (47%) in IRIS 2, 77/109 (71%) in IRIS 3, and 117/142 (82%) in IRIS 4. Dogs at IRIS stages 3 and 4 were more likely to have moderate to severe anemia, compared to dogs at IRIS stage 2 (p = 0.0001). Anisocytosis was the most frequent morphological abnormality (291/482; 60%), whereas the presence of poikilocytosis showed an association with progression of IRIS stages (p = 0.009). Among different morphological abnormalities, the frequency of fragmented red blood cells and Howell–Jolly bodies showed a significant association with the progression of CKD. Anemia was a frequent finding in CKD dogs, mostly associated with none to poor regeneration rate. Similar to human medicine, advanced CKD stages are more frequently characterized by morphological alterations, such as fragmented red blood cells and Howell–Jolly bodies, which may suggest a more severe condition of reduced bone marrow activity and microangiopathy.

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De novo methylation of tumor suppressor gene p16/INK4a is a frequent finding in multiple myeloma patients at diagnosis

Leukemia ◽

10.1038/sj.leu.2401617 ◽

2000 ◽

Vol 14 (1) ◽

pp. 183-187 ◽

Cited By ~ 43

Author(s):

M González ◽

MV Mateos ◽

R García-Sanz ◽

A Balanzategui ◽

R López-Pérez ◽

...

Keyword(s):

Multiple Myeloma ◽

Tumor Suppressor ◽

Tumor Suppressor Gene ◽

De Novo ◽

Suppressor Gene ◽

Frequent Finding ◽

P16 Ink4a ◽

De Novo Methylation

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Bacterial Contamination During Diagnostic and Interventional Neuroangiography is a Frequent Finding: But Does It Matter? An Observational Study

Clinical Neuroradiology ◽

10.1007/s00062-015-0431-x ◽

2015 ◽

Vol 27 (1) ◽

pp. 39-42

Author(s):

C. Kabbasch ◽

F. Dorn ◽

H.M. Wenchel ◽

B. Krug ◽

A. Mpotsaris ◽

...

Keyword(s):

Observational Study ◽

Bacterial Contamination ◽

Frequent Finding

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Rendimiento diagnóstico de la videocápsula endoscópica en el sangrado del intestino delgado manifiesto

Acta gastroenterológica latinoamericana ◽

10.52787/dzvw9801 ◽

2020 ◽

Vol 50 (4) ◽

Author(s):

María Alejandra Arriola ◽

Diana Valencia ◽

Carolina Olano

Keyword(s):

Small Bowel ◽

Capsule Endoscopy ◽

Diagnostic Yield ◽

Laboratory Data ◽

Increased Risk ◽

Frequent Finding ◽

Male Sex ◽

Lower Endoscopy ◽

Small Bowel Bleeding ◽

Nonspecific Inflammation

Introduction. The small bowel capsule endoscopy is the first line procedure in patients with suspected small bowel bleeding. Data regarding overt suspected small bowel bleeding and its predictive factors remain still limited. Aim. To assess the diagnostic yield of the capsule endoscopy and the factors predicting positive findings in patients with overt suspected small bowel bleeding. Methods. Patients with overt suspected small bowel bleeding (melena or enterorrhagia) and negative upper and lower endoscopy were included. A positive diagnostic yield was considered when the capsule endoscopy diagnosed one or more P2 or P3 type lesions (Modified Saurin Classification) Demographic and laboratory data were recorded. Results. 79 patients were included (mean age 62.92 (15-89); F:M 46:33). The diagnostic yield of the capsule endoscopy was 62%. The most frequent finding was angioectasia (44.8%), followed by nonspecific inflammation/ulceration (20.4%). The multivariate analysis found that age older than 50 years and male sex were independent variables that were associated with an increased risk of positive findings and angioectasia. Conclusions. In this group of patients with overt suspected small bowel bleeding, the capsule endoscopy was useful (with a diagnostic yield of 62%). The most frequent lesions were the vascular ones. Age over 50 and male sex were independent predictors of finding lesions and angioectasia.

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Calcium pyrophosphate deposition disease: a frequent finding in patients with long-standing erosive gout

Scandinavian Journal of Rheumatology ◽

10.1080/03009742.2017.1332239 ◽

2017 ◽

Vol 47 (2) ◽

pp. 127-130 ◽

Cited By ~ 8

Author(s):

B Ankli ◽

D Kyburz ◽

A Hirschmann ◽

T Hügle ◽

T Manigold ◽

...

Keyword(s):

Calcium Pyrophosphate ◽

Calcium Pyrophosphate Deposition Disease ◽

Deposition Disease ◽

Frequent Finding

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Effect of insulin on uric acid excretion in humans

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.1995.268.1.e1 ◽

1995 ◽

Vol 268 (1) ◽

pp. E1-E5 ◽

Cited By ~ 37

Author(s):

A. Quinones Galvan ◽

A. Natali ◽

S. Baldi ◽

S. Frascerra ◽

G. Sanna ◽

...

Keyword(s):

Uric Acid ◽

Plasma Insulin ◽

Excretion Rate ◽

Fractional Excretion ◽

Urine Flow ◽

Insulin Resistant ◽

Fasting Plasma ◽

Frequent Finding ◽

Fasting Plasma Insulin ◽

Induced Changes

Although hyperuricemia is a frequent finding in insulin-resistant states, insulin's effect on renal uric acid (UA) handling is not known. In 20 healthy volunteers, diastolic blood pressure, body weight, and fasting plasma insulin were positively (and age was negatively) related to fasting plasma UA concentrations, together accounting for 53% of their variability. During an insulin clamp, urine flow was lower than during fasting conditions (1.01 +/- 0.12 vs. 1.56 +/- 0.32 ml/min, P = 0.04), whereas creatinine clearance was unchanged (129 +/- 7 and 131 +/- 9 ml/min, P = not significant). Hyperinsulinemia did not alter serum UA concentrations (303 +/- 13 vs. 304 +/- 12 microM) but caused a significant decrease in urinary UA excretion [whether expressed as absolute excretion rate (1.66 +/- 0.21 vs. 2.12 +/- 0.23 mumol/min, P = 0.03), clearance rate (5.6 +/- 0.8 vs. 7.3 +/- 0.8 ml/min, P = 0.03), or fractional excretion (4.48 +/- 0.80 ml/min vs. 6.06 +/- 0.64%, P < 0.03)]. Hyperinsulinemia was also associated with a 30% (P < 0.001) fall in urine Na excretion. Fractional UA excretion was related to Na fractional excretion under basal conditions (r = 0.59, P < 0.01) and during the insulin period (r = 0.53, P < 0.02). Furthermore, the insulin-induced changes in fractional UA and Na excretion correlated with one another (r = 0.66, P < 0.001). Physiological hyperinsulinemia acutely reduces urinary UA and Na excretion in a coupled fashion.

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Insomnia is a frequent finding in adults with Asperger syndrome

BMC Psychiatry ◽

10.1186/1471-244x-3-12 ◽

2003 ◽

Vol 3 (1) ◽

Cited By ~ 47

Author(s):

Pekka Tani ◽

Nina Lindberg ◽

Taina Nieminen-von Wendt ◽

Lennart von Wendt ◽

Lauri Alanko ◽

...

Keyword(s):

Asperger Syndrome ◽

Frequent Finding

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Histopathological Changes in Helicobacter pylori Associated Gastritis and Scope of Special Stain and Immunohistochemistry as Diagnostic Aids

Journal of Evidence Based Medicine and Healthcare ◽

10.18410/jebmh/2020/618 ◽

2020 ◽

Vol 7 (50) ◽

pp. 3027-3032

Author(s):

Ruby Elizabeth Elias ◽

Bindiya Gisuthan ◽

Sreeganesh A.S

Keyword(s):

Helicobacter Pylori ◽

Positive Predictive Value ◽

Negative Predictive Value ◽

Chronic Gastritis ◽

Predictive Value ◽

Diagnostic Methods ◽

P Value ◽

Special Stain ◽

Frequent Finding ◽

H Pylori

BACKGROUND Helicobacter pylori associated chronic gastritis plays a vital role in the development of majority of gastric adenocarcinomas and most gastric MALT (Mucosa Associated Lymphoid Tissue) lymphomas. Many diagnostic methods are available for the identification of this organism. However, in gastroenterology practice, histopathological examination of biopsy samples provides visual identification of the pathogen and the associated mucosal changes with special stains like Giemsa. The aim of this study was to evaluate the efficacy of three stains H & E- (Haematoxylin and Eosin), Giemsa and IHC (Immunohistochemistry) in the identification of H. pylori. Associated histologic changes were noted and the relationship between the degree of colonisation and the activity and chronicity of gastritis were analysed. METHODS 585 gastric biopsies taken from dyspeptic patients were evaluated for gastritis, based on updated Sydney System. In 250 randomly selected cases, three staining methods were used. RESULTS Out of 585 cases, 413 (70.60 %) had features of chronic gastritis. Mild chronic gastritis was the commonest finding and is seen in most cases of mild H. pylori colonisation. When activity was monitored, mild activity was the most frequent finding [225 (38.46 %)]. Majority of the severe activity cases showed severe H. pylori colonisation. 13.16 %, 4.79 % and 7.35 % showed intestinal metaplasia, atrophy and dysplastic changes respectively. Out of 250 cases, H & E and Giemsa stains showed 45.6 % and 57.2 % positivity while IHC demonstrated maximum number of positivity (156 cases - 62.4 %). Sensitivity and specificity of H & E was found to be 77.90 % and 98.95 %, positive predictive value was 99.13 % and negative predictive value was 69.18 %. For Giemsa stain, sensitivity was 91.67 %, specificity was 100 %, positive predictive value was 100 % and negative predictive value was 87.85 %. DISCUSSION H. pylori gastritis was a frequent finding in dyspeptic patients in southern part of India. When chi-square test was done, a significant statistical relationship between the severity of H. pylori colonisation, activity and chronicity of gastritis was noted. P value was < 0.001. With the use of special stain, Giemsa and ancillary techniques like IHC, the detection rate of H. pylori was enhanced considerably. CONCLUSIONS With increasing number of H. pylori in the mucosa, there was increase in the chronicity and activity of gastritis. Although immunohistochemistry revealed more cases of H. pylori, Giemsa can be a cost-effective substitute, because of its high specificity and positive predictive value. KEYWORDS H. pylori Gastritis, Giemsa, Haematoxylin and Eosin Stain, Immunohistochemistry

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Periodontal intervention effects on pregnancy outcomes in women with preeclampsia.

Colombia Medica ◽

10.25100/cm.v40i2.640 ◽

1969 ◽

Vol 40 (2) ◽

pp. 177-184

Author(s):

Julián A. Herrera ◽

Santiago Vélez Medina ◽

Rodolfo Molano ◽

Virna Medina ◽

Javier E. Botero ◽

...

Keyword(s):

Birth Weight ◽

Gestational Age ◽

Hellp Syndrome ◽

Severe Preeclampsia ◽

Maternal Complications ◽

Frequent Finding ◽

Mild Preeclampsia ◽

Social Demographic ◽

Study Inclusion ◽

Clinical Stability

Objective: To determine the efficacy of periodontal intervention on pregnancy outcome in mild preeclamptic women. Methods: A sample of 60 pregnant women with mild preeclampsia (blood pressure levels < 160/110 mm and proteinuria >300 mg/l in 24 hours urine) from the Hospital Universitario del Valle (Cali, Colombia) was included to the study. Preeclamptic women were randomized in two groups, one with periodontal intervention (PIG, N=28) and another in which the periodontal intervention was practiced after childbirth (NPIG, N=32). Maternal socio-demographic, medical and periodontal data were obtained. PIG included patients in which supragingival and subgingival cleaning within ultrasonic and manual devices were performed after study inclusion. The progression from mild to severe preeclampsia, eclampsia or HELLP syndrome, the number of days of clinical stability and the percentile of birth-weight adjusted for gestational age were evaluated in both groups. Results: Most of the patients (60%) were multigravids. Gestational age at inclusion was 31.8±1.6 weeks. Chronic periodontitis was a frequent finding (61.7%). Social, demographic, medical and periodontal conditions were similar between both groups. Disease progression to severe preeclampsia, eclampsia or HELLP syndrome was also similar (89.2% PIG versus 84.4%, p=0.65) (OR=1.06 IC 95% 0.87-1.29, p=0.65). Days of clinical stability were similar between the groups (median 10 days , range 1-46, PIG versus 12 days, range 1-59, p=0.57) and the percentile of birth weight adjusted with gestational age had no differences between the groups (median percentil 50 range 5-90 PIG versus percentil 55 range 5-95, p=0.73). Conclusion: Periodontal intervention does not seem to harm the health, the severity or alter the frequency on maternal complications in mild preeclampsia subjects.

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