Antimicrobial activity of polyurethanes coated with antibiotics: a new approach to the realization of medical devices exempt from microbial colonization

2004 ◽  
Vol 280 (1-2) ◽  
pp. 173-183 ◽  
Author(s):  
A Piozzi ◽  
I Francolini ◽  
L Occhiaperti ◽  
M Venditti ◽  
W Marconi
Keyword(s):  
Antimicrobial Activity ◽  
Medical Devices ◽  
Microbial Colonization ◽  
New Approach

Processing Considerations for Salicylic Acid-Based Polymers

2003 ◽  
Author(s):  
Eva Wagner ◽  
Kathryn Uhrich ◽  
Thomas Twardowski
Keyword(s):  
Salicylic Acid ◽  
Controlled Release ◽  
Temperature Dependence ◽  
Medical Devices ◽  
Melt Processing ◽  
The Body ◽  
Hollow Fibers ◽  
New Approach ◽  
Degradable Polymer ◽  
Solution Spinning

This paper describes some of the processing issues for extruding salicylic acid-based polymer prodrugs into fibers for medical devices. Polymeric prodrugs, in which a drug is polymerized in a degradable polymer that delivers controlled quantity of the drug to a targeted site in the body as the device degrades, are a new approach to controlled release. Hollow fibers were produced by solution spinning. Solid fibers were formed by melt processing. The salicylic acid polymers exhibited shear-thinning behavior. The viscosity exhibited pronounced temperature dependence.

Can rhamnose-based glycolipids nanoparticles be an alternative to fight biofilms on medical devices?

2020 ◽  
Author(s):  
Carolina Tomé ◽  
Inês Anjos ◽  
Victor Martin ◽  
Catarina Santos ◽  
Lidia Gonçalves ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Zeta Potential ◽  
Medical Devices ◽  
Encapsulation Efficiency ◽  
Inhibitory Concentration ◽  
Control Cell ◽  
Chitosan Nanoparticles ◽  
Biofilm Inhibition ◽  
Promising Alternative ◽  
Biofilm Development

<p>Biofilm development on medical devices is of particular concern and finding new strategies for preventing surface colonization and infection development are urgent. Antimicrobial biosurfactants such as rhamnolipids (RLs), emerge as one possible solution due their lack of resistance development. Using nanoparticles as delivery systems for these compounds may be a promising alternative in the context of biofilm-infections control. As such, the aim of this study was to encapsulate RLs into chitosan nanoparticles (RLs-NPs), test their antimicrobial activity and their biocompatibility profile.</p> <p>Blank nanoparticles (b-NPs) and RLs-NPs were prepared by ionic gelation. For particles characterization, zeta potential, size distribution and encapsulation efficiency were performed. Minimal inhibitory concentration and biofilm inhibition ability were evaluated towards Staphylococcus aureus (ATCC 25923). To access NPs cytocompatibility the in vitro tetrazolium dye assay (MTT) and morphology observation were performed with a mouse fibroblastic cell line (L929).</p> <p>RLs-NPs presented an encapsulation efficiency of 74.2±1.3%, a size ranging from 300 to 400 nm and a zeta potential of  37±1 mV. The minimum inhibitory concentration of RLs-NPs was 130 mg/mL and a 99% biofilm inhibition was achieved with these NPs meaning that their antimicrobial activity is also effective towards sessile bacteria. When compared to control, cell cultures grown in the presence of RLs-NPs presented no significant differences regarding the MTT reduction values and morphology analysis, suggesting that NPs up to 500 mg/mL did not significantly interfere with viability and proliferation.</p> <p>The results revealed that the RLs-NPs were able to inhibit bacterial growth showing adequate cytocompatibility and might become, after additional studies, a possible approach to fight S. aureus biofilm associated infections.</p> <p><strong>Acknowledgments: </strong>Support for this work was provided by FCT through Portuguese government, PTDC/BTM-SAL/29335/2017 and Pest-UID/DTP/04138/2019</p>

Efficacy of Combination of N-acetylcysteine, Gentamicin, and Amphotericin B for Prevention of Microbial Colonization of Ventricular Assist Devices

2009 ◽  
Vol 30 (2) ◽  
pp. 190-192 ◽  
Author(s):  
Maria D. Hernandez ◽  
Mohammad D. Mansouri ◽  
Saima Aslam ◽  
Barry Zeluff ◽  
Rabih O. Darouiche
Keyword(s):  
Antimicrobial Activity ◽  
Amphotericin B ◽  
Rabbit Model ◽  
Microbial Colonization ◽  
Ventricular Assist Devices ◽  
Ventricular Assist ◽  
In Vivo Efficacy ◽  
Assist Devices

We assessed the in vitro antimicrobial activity and the in vivo efficacy of dipping ventricular assist devices in a combination of N-acetylcysteine, gentamicin, and amphotericin B (NAC/G/A). Ventricular assist devices dipped in NAC/G/A exhibited broad-spectrum antimicrobial activity in vitro and were less likely than undipped devices to become colonized with Staphylococcus aureus in a rabbit model.

The Crowd, the Cloud and Improving the Future of Medical Device Innovation

2014 ◽  
Vol 17 (1) ◽  
pp. 13-20
Author(s):  
Marco Huesch ◽  
Robert Szczerba
Keyword(s):  
Medical Device ◽  
Medical Devices ◽  
Business Models ◽  
Regulatory Environment ◽  
New Approach ◽  
Current State ◽  
Development Processes ◽  
Reducing Costs ◽  
Innovation Practices ◽  
Start Ups

Abstract Barriers and delays to medical device innovation are often solely attributable to the regulatory environment instead of both the current state of innovation practices and product development processes in the industry. Increasing the pace of innovation while reducing costs requires the creation of a new approach that fits both established medical device corporations as well as entrepreneurial start-ups. In this commentary we advance the concept of innovation platforms to facilitate ideation in the medical device space. Such platforms could also allow the full health benefits from individual medical devices to be reaped, by overcoming interoperability concerns through simulation and credentialing. Given the dramatic benefits of medical device success, such non-traditional business models for development may be potential solutions for industry, users and regulators.

scholarly journals Preventing Biofilm Formation and Development on Ear, Nose and Throat Medical Devices

Biomedicines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 1025
Author(s):  
Dan Cristian Gheorghe ◽  
Andrei Ilie ◽  
Adelina-Gabriela Niculescu ◽  
Alexandru Mihai Grumezescu
Keyword(s):  
Medical Devices ◽  
Biofilm Formation ◽  
Microbial Colonization ◽  
Long Time ◽  
3D Matrix ◽  
Common Problems ◽  
Underlying Mechanisms ◽  
Surface Modification Techniques ◽  
Biofilm Development ◽  
Nose And Throat

Otorhinolaryngology is a vast domain that requires the aid of many resources for optimal performance. The medical devices utilized in this branch share common problems, such as the formation of biofilms. These structured communities of microbes encased in a 3D matrix can develop antimicrobial resistance (AMR), thus making it a problem with challenging solutions. Therefore, it is of concern the introduction in the medical practice involving biomaterials for ear, nose and throat (ENT) devices, such as implants for the trachea (stents), ear (cochlear implants), and voice recovery (voice prosthetics). The surface of these materials must be biocompatible and limit the development of biofilm while still promoting regeneration. In this respect, several surface modification techniques and functionalization procedures can be utilized to facilitate the success of the implants and ensure a long time of use. On this note, this review provides information on the intricate underlying mechanisms of biofilm formation, the large specter of implants and prosthetics that are susceptible to microbial colonization and subsequently related infections. Specifically, the discussion is particularized on biofilm development on ENT devices, ways to reduce it, and recent approaches that have emerged in this field.

A New Approach to Stress Analysis of Vascular Devices Using High Resolution Thermoelastic Stress Analysis

2006 ◽  
Vol 5-6 ◽  
pp. 63-70 ◽  
Author(s):  
James Eaton-Evans ◽  
Janice M. Dulieu-Barton ◽  
Edward G. Little ◽  
Ian A. Brown
Keyword(s):  
High Resolution ◽  
Stress Analysis ◽  
Medical Devices ◽  
Thermoelastic Stress ◽  
Thermoelastic Stress Analysis ◽  
New Approach ◽  
Full Field ◽  
Vascular Stents ◽  
Thermoelastic Response ◽  
Quantitative Stress

Thermoelastic Stress Analysis (TSA) is a non-contacting technique that provides full field stress information and can record high-resolution measurements from small structures. The work presented in this paper summarises the application of TSA to two types of small medical devices that are used to treat diseased arteries; angioplasty balloons and vascular stents. The use of high resolution optics is described along with a calibration methodology that allows quantitative stress measurements to be taken from the balloon structure. A brief account of a study undertaken to characterise the thermoelastic response from Nitinol is also included and it is demonstrated that thermoelastic data can be obtained from a stent at high resolutions.

The Legislation and Regulation of Medical Devices

2021 ◽  
pp. 177-194
Keyword(s):  
European Commission ◽  
Medical Devices ◽  
Product Safety ◽  
Regulatory Environment ◽  
New Approach ◽  
Legislative History ◽  
The Core ◽  
Regulatory Bodies ◽  
The Impact ◽  
The Eu

This chapter outlines the laws that govern the manufacture and supply of medical devices in the EU and UK, both multi-faceted and internationally well-regarded legislative regimes. It contextualises these laws within the broader framework of the EU’s new approach to product safety legislation, in which these medical devices regimes were established. It discusses the core principles and fundamental statutory concepts under the EU and UK legislation that have been reinforced and improved upon over forty years of legislative history. Recent legislative change and the impact of Brexit is discussed in detail in that regard. The chapter also describes the regulatory environment in which Europe’s substantial medical devices industry operates, an industry which is estimated by the European Commission in 2019 as being comprised of 500,000 different types of medical devices and worth €100 billion. An outline of key regulatory bodies and functions is also provided.

Recent progress in Tannic Acid-driven antimicrobial/antifouling surface coating strategies

2022 ◽  
Author(s):  
Gnanasekar Sathishkumar ◽  
Gopinath Kasi ◽  
Kai Zhang ◽  
En-Tang Kang ◽  
Liqun Xu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Tannic Acid ◽  
Medical Devices ◽  
Surface Coating ◽  
Recent Progress ◽  
Microbial Colonization ◽  
Implant Surface ◽  
Surgical Implants ◽  
Regenerative Medicines

Medical devices and surgical implants are a necessary part of tissue engineering and regenerative medicines. However, the biofouling and microbial colonization on the implant surface continues to be a major...

A Review on Antimicrobial Coatings for Biomaterial Implants and Medical Devices

2020 ◽  
Vol 16 (6) ◽  
pp. 789-809
Author(s):  
Long Chen ◽  
Xinyu Song ◽  
Fei Xing ◽  
Yanan Wang ◽  
Yuanzheng Wang ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Medical Devices ◽  
Modern Medicine ◽  
Implant Surface ◽  
Antimicrobial Coatings ◽  
Antimicrobial Coating ◽  
Compound Ii ◽  
Topical Antimicrobial

Biomaterial implants and medical devices have been utilized extensively in medical treatment with the development of modern medicine, especially in orthopaedics and stomatology. Along with their applications, biomaterial-associated infections (BAIs) have grown to be one of the main postoperative complications. Antimicrobial coating strategies have been reported to effectively inhibit bacterial adhesion and proliferation on implant surface, extending their lifespan. In this review, the most topical antimicrobial coating designs have been chosen from literature studies. Their antimicrobial mechanisms and antimicrobial activity assessments in literature studies have been presented and compared. Based on their active ingredients, antimicrobial coatings are categories into (i) inorganic agents, including Ag, Cu, ZnO, MoS2 and nitride compound; (ii) organic agents including antibiotic, antimicrobial peptides, polymer, essential oils etc. The review has provided various and detailed options of antimicrobial coating designs for consulting according to their specific application. It is noted that the research of antimicrobial coatings is mostly in vitro and in vivo animal models study. It is thus in need for more preclinical or clinical studies, especially finding the direct connection between the utilization of antimicrobial coated implants and the reduction in BAIs incidence. Furthermore, future antimicrobial coating designs shall respect also biocompatibility, functionality, and durability apart from their antimicrobial activity.

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