Solid dispersion particles of amorphous indomethacin with fine porous silica particles by using spray-drying method

2005 ◽  
Vol 293 (1-2) ◽  
pp. 155-164 ◽  
Author(s):  
Hirofumi Takeuchi ◽  
Shinsuke Nagira ◽  
Hiromitsu Yamamoto ◽  
Yoshiaki Kawashima
Keyword(s):  
Spray Drying ◽  
Solid Dispersion ◽  
Porous Silica ◽  
Silica Particles ◽  
Drying Method ◽  
Amorphous Indomethacin

Solid dispersion particles of tolbutamide prepared with fine silica particles by the spray-drying method

2004 ◽  
Vol 141 (3) ◽  
pp. 187-195 ◽  
Author(s):  
Hirofumi Takeuchi ◽  
Shinsuke Nagira ◽  
Hiromitsu Yamamoto ◽  
Yoshiaki Kawashima
Keyword(s):  
Spray Drying ◽  
Solid Dispersion ◽  
Silica Particles ◽  
Drying Method

scholarly journals ENHANCEMENT OF DISSOLUTION AND STABILITY OF CANDESARTAN CILEXETIL–LOADED SILICA POLYMERS

2019 ◽  
pp. 64-70
Author(s):  
Mai Khanfar ◽  
Bashar Al Taani ◽  
Eman Mohammad
Keyword(s):  
Spray Drying ◽  
Solid Dispersion ◽  
Candesartan Cilexetil ◽  
Solid Dispersions ◽  
Porous Silica ◽  
Amorphous Solid ◽  
Silica Particles ◽  
Scanning Calorimetry ◽  
X Ray ◽  
Spray Dried

Objective: To prepare stable amorphous solid dispersions of candesartan cilexetil (CAN) with different types of silica, including non-porous (aerosil 200) and porous silica (sylysia 350) using the spray-drying method. Methods: various ratios of candesartan cilexetil (CAN) were spray dried with aerosil and sylysia. Powder x-ray diffraction (x-ray) differential scanning calorimetry (DSC), SEM were used to characterize the spray dried powders in addition to dissolution and stability studies. Results: X-ray results showed that the spray–dried (CAN) in the prepared solid dispersion were in amorphous form irrespective of the used silica. In (DSC) analysis, the melting peak of spray-dried (CAN-silica) solid dispersion disappeared. Dissolution property of (CAN) was remarkably improved by formulating with silica particles. In comparing the effect of the type of the silica particles, the dissolution rate of (CAN) from the spray-dried (CAN-sylysia) was faster than that (CAN-aerosil 200) irrespective of the drug content. It was also shown that the spray-dried formulation with silica did not recrystallize when storing at severe storage conditions (40 °C, 75% RH) for three months, while spray-dried (CAN) without silica easily re-crystallized under the same conditions. Conclusion: Spray drying of (CAN) with sylysia 350 is an efficient method to enhance the dissolution and stability of the drug.

Formulation and Process Optimization of Solid Dispersion of Meloxicam and PEG8000 Prepared by Spray Drying

2009 ◽  
Vol 2 (3) ◽  
pp. 647-653
Author(s):  
Patel R.P. ◽  
Patel M. P. ◽  
Suthar A. M. ◽  
Baria A.H.
Keyword(s):  
Particle Size ◽  
Spray Drying ◽  
Solid Dispersion ◽  
Feed Rate ◽  
Polymer Concentration ◽  
Drug Dissolution ◽  
In Vitro Dissolution ◽  
Inlet Temperature ◽  
Drying Method ◽  
Melting Method

The poor solubility and wettability of meloxicam leads to poor dissolution and hence shows poor bioavailability. The present study is aimed at increasing solubility of drug using solid dispersion technique. The solid binary systems were prepared using different drug: polymer ratio (1:1, 1:5 and 1:10) with polyethylene glycol 8000 by different techniques like physical mixing, melting method and spray drying method. The formulations were characterized by differential scanning colorimetry, scanning electron microscopy and in vitro dissolution rate studies. The solubility of drug increased linearly with the increase in polymer concentration. The solid dispersion of drug prepared by spray drying method demonstrated higher drug dissolution rates in comparison to solid dispersion prepared by physical mixtures, melting method and pure meloxicam. Moreover, spray drying process parameters inlet air temperature and feed rate were also optimized to obtain maximum powder yield and satisfactory particle size and compressibility. The outcome indicated that with the increase in feed rate, the powder yield and Carr’s index decreases but particle size increases. On the other hand, as the inlet temperature increases, powder yield and Carr’s index increases.

scholarly journals Tabletting of Solid Dispersion Particles Consisting of Indomethacin and Porous Silica Particles

2005 ◽  
Vol 53 (5) ◽  
pp. 487-491 ◽  
Author(s):  
Hirofumi Takeuchi ◽  
Shinsuke Nagira ◽  
Shinji Tanimura ◽  
Hiromitsu Yamamoto ◽  
Yoshiaki Kawashima
Keyword(s):  
Solid Dispersion ◽  
Porous Silica ◽  
Silica Particles

Effect of Spray Drying Method on the Properties of Glimepiride-loaded Solid Dispersion

Yakhak Hoeji ◽  
2021 ◽  
Vol 65 (6) ◽  
pp. 487-493
Author(s):  
Hyun Seok Yang ◽  
Yu Rim Oh ◽  
Dong Wuk Kim
Keyword(s):  
Spray Drying ◽  
Solid Dispersion ◽  
Drying Method

scholarly journals Preparation of LiFePO4 Powders by Ultrasonic Spray Drying Method and Their Memory Effect

Materials ◽  
2021 ◽  
Vol 14 (12) ◽  
pp. 3193
Author(s):  
Tu Lan ◽  
Xiaolong Guo ◽  
De Li ◽  
Yong Chen
Keyword(s):  
Spray Drying ◽  
Memory Effect ◽  
Electrode Materials ◽  
Average Particle Size ◽  
Lithium Ion ◽  
Average Particle ◽  
Preparation Process ◽  
Drying Method ◽  
Drying Temperature ◽  
Ultrasonic Spray

The memory effect of lithium-ion batteries (LIBs) was first discovered in LiFePO4, but its origin and dependence are still not clear, which is essential for regulating the memory effect. In this paper, a home-made spray drying device was used to successfully synthesize LiFePO4 with an average particle size of about 1 μm, and we studied the influence of spray drying temperature on the memory effect of LiFePO4 in LIBs. The results showed that the increasing of spray drying temperature made the memory effect of LiFePO4 strengthen from 1.3 mV to 2.9 mV, while the capacity decreased by approximately 6%. The XRD refinement and FTIR spectra indicate that the enhancement of memory effect can be attributed to the increment of Li–Fe dislocations. This work reveals the dependence of memory effect of LiFePO4 on spray drying temperature, which will guide us to optimize the preparation process of electrode materials and improve the management system of LIBs.

scholarly journals A Brief Overview of Recent Progress in Porous Silica as Catalyst Supports

2021 ◽  
Vol 5 (3) ◽  
pp. 75
Author(s):  
Preeti S. Shinde ◽  
Pradnya S. Suryawanshi ◽  
Kanchan K. Patil ◽  
Vedika M. Belekar ◽  
Sandeep A. Sankpal ◽  
...  
Keyword(s):  
Heterogeneous Catalysis ◽  
High Surface ◽  
High Surface Area ◽  
Porous Silica ◽  
Textural Properties ◽  
Silica Particles ◽  
Catalyst Supports ◽  
Silica Supports ◽  
Low Degree ◽  
Transfer Properties

Porous silica particles have shown applications in various technological fields including their use as catalyst supports in heterogeneous catalysis. The mesoporous silica particles have ordered porosity, high surface area, and good chemical stability. These interesting structural or textural properties make porous silica an attractive material for use as catalyst supports in various heterogeneous catalysis reactions. The colloidal nature of the porous silica particles is highly useful in catalytic applications as it guarantees better mass transfer properties and uniform distribution of the various metal or metal oxide nanocatalysts in solution. The catalysts show high activity, low degree of metal leaching, and ease in recycling when supported or immobilized on porous silica-based materials. In this overview, we have pointed out the importance of porous silica as catalyst supports. A variety of chemical reactions catalyzed by different catalysts loaded or embedded in porous silica supports are studied. The latest reports from the literature about the use of porous silica-based materials as catalyst supports are listed and analyzed. The new and continued trends are discussed with examples.

scholarly journals Enhanced Oral Bioavailability of Resveratrol by Using Neutralized Eudragit E Solid Dispersion Prepared via Spray Drying

Antioxidants ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 90
Author(s):  
Eun-Sol Ha ◽  
Du Hyung Choi ◽  
In-hwan Baek ◽  
Heejun Park ◽  
Min-Soo Kim
Keyword(s):  
Spray Drying ◽  
Solid Dispersion ◽  
Oral Bioavailability ◽  
Solid Dispersions ◽  
Amorphous Solid ◽  
Pharmaceutical Products ◽  
In Vitro Dissolution ◽  
Dependent Manner ◽  
Amorphous Solid Dispersions ◽  
Eudragit E

In this study, we designed amorphous solid dispersions based on Eudragit E/HCl (neutralized Eudragit E using hydrochloric acid) to maximize the dissolution of trans-resveratrol. Solid-state characterization of amorphous solid dispersions of trans-resveratrol was performed using powder X-ray diffraction, scanning electron microscopy, and particle size measurements. In addition, an in vitro dissolution study and an in vivo pharmacokinetic study in rats were carried out. Among the tested polymers, Eudragit E/HCl was the most effective solid dispersion for the solubilization of trans-resveratrol. Eudragit E/HCl significantly inhibited the precipitation of trans-resveratrol in a pH 1.2 dissolution medium in a dose-dependent manner. The amorphous Eudragit E/HCl solid dispersion at a trans-resveratrol/polymer ratio of 10/90 exhibited a high degree of supersaturation without trans-resveratrol precipitation for at least 48 h by the formation of Eudragit E/HCl micelles. In rats, the absolute oral bioavailability (F%) of trans-resveratrol from Eudragit E/HCl solid dispersion (10/90) was estimated to be 40%. Therefore, trans-resveratrol-loaded Eudragit E/HCl solid dispersions prepared by spray drying offer a promising formulation strategy with high oral bioavailability for developing high-quality health supplements, nutraceutical, and pharmaceutical products.

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