Double emulsions based on silicone-fluorocarbon-water and their skin penetration

Nanotechnology is currently a hot topic in dermatology and nutraceutical/cosmeceutical delivery, owing to the advantages it provides in terms of enhancing the skin permeation of drugs, as well as increasing their therapeutic efficacy in the treatment of different dermatological diseases. There is also a great interest in the topical delivery of nutraceuticals; which are natural compounds with both therapeutic and cosmetic benefits, in order to overcome the side effects of topically applied chemical drugs. Quercetin is a key nutraceutical with topical antioxidant and anti-inflammatory properties which was reported to be effective in the treatment of different dermatological diseases, however, its topical therapeutic activity is hindered by its poor skin penetration. This review highlights the topical applications of quercetin, and summarizes the nanocarrier-based solutions to its percutaneous delivery challenges.

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Status of Fatty Acids as Skin Penetration Enhancers-A Review

Current Drug Delivery ◽

10.2174/156720109788680877 ◽

2009 ◽

Vol 6 (3) ◽

pp. 274-279 ◽

Cited By ~ 15

Author(s):

Ashu Mittal ◽

U. Sara ◽

Asgar Ali ◽

Mohd. Aqil

Keyword(s):

Fatty Acids ◽

Skin Penetration ◽

Penetration Enhancers

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Green Synthesis of Copper Oxide Nanoparticles using Cucumis sativus (cucumber) Extracts and their Bio-physical and Biochemical Characterization for Cosmetic and Dermatologic Applications

Endocrine Metabolic & Immune Disorders - Drug Targets ◽

10.2174/1871530320666200705212107 ◽

2020 ◽

Vol 20 ◽

Author(s):

Monika Vats ◽

Shruti Bhardwaj ◽

Arvind Chhabra

Keyword(s):

Copper Oxide ◽

Green Synthesis ◽

Biochemical Characterization ◽

Chemical Characterization ◽

Ultra Violet ◽

Skin Penetration ◽

Copper Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Ultra Violet Radiation ◽

Anti Fungal

Background & Objective: Nanoparticles are used in cosmetic and dermatologic products, due to better skin penetration properties. Incorporation of natural products exhibiting medicinal properties in nano-preparations could significantly improve efficacy of these products and improve the quality of life without the side effects of synthetic formulations. Methods: We here report green synthesis of Copper Oxide nanoparticles, using Cucumber extract, and their detailed biophysical and bio-chemical characterization. Results: These Copper Oxide-Cucumber nanoparticles exhibit significant anti-bacterial and anti-fungal properties, Ultra Violet-radiation protection ability and reactive-oxygen species inhibition properties. Importantly, these nanoparticles do not exhibit significant cellular toxicity and, when incorporated in skin cream, exhibit skin rejuvenating properties. Conclusion: Our findings have implications for nanoparticle-based cosmetics and dermatologic applications.

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Impact of incorporating double emulsions with bioactive compounds of acid cactus fruits in emulsified meat products during storage

Journal of Food Processing and Preservation ◽

10.1111/jfpp.15477 ◽

2021 ◽

Author(s):

Rafael Germán Campos‐Montiel ◽

Nestor Santos‐Ordoñez ◽

Isaac Almaraz‐Buendía ◽

Gabriel Aguirre‐Álvarez ◽

José Jesús Espino‐García ◽

...

Keyword(s):

Bioactive Compounds ◽

Meat Products ◽

Double Emulsions ◽

Emulsified Meat

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Ultrasound-Guided Popliteal Nerve Block with Short-Acting Lidocaine in the Surgical Treatment of Ingrown Toenails

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18105059 ◽

2021 ◽

Vol 18 (10) ◽

pp. 5059

Author(s):

Beom Suk Kim ◽

Kyungho Kim ◽

Jonathan Day ◽

Jesse Seilern Und Seilern Und Aspang ◽

Jaeyoung Kim

Keyword(s):

Surgical Treatment ◽

Adverse Events ◽

Nerve Block ◽

Skin Penetration ◽

Sensory Block ◽

Foot And Ankle ◽

Ingrown Toenail ◽

Ankle Surgery ◽

Ingrown Toenails ◽

Digital Nerve Block

Background: Digital nerve block (DB) is a commonly utilized anesthetic procedure in ingrown toenail surgery. However, severe procedure-related pain has been reported. Although the popliteal sciatic nerve block (PB) is widely accepted in foot and ankle surgery, its use in ingrown toenail surgery has not been reported. Therefore, this study aimed to investigate the safety and effectiveness of PB in the surgical treatment of ingrown toenails. Methods: One-hundred-ten patients surgically treated for an ingrown toenail were enrolled. Sixty-six patients underwent DB, and 44 underwent PB. PB was performed under ultrasound-guidance via a 22-gauge needle with 15 mL of 1% lidocaine in the popliteal region. The visual analogue scale was used to assess pain at two-time points: pain with skin penetration and pain with the solution injection. Time to sensory block, duration of sensory block, need for additional injections, and adverse events were recorded. Results: PB group demonstrated significantly lower procedure-related pain than the DB group. Time to sensory block was significantly longer in the PB group (20.8 ± 4.6 versus 6.5 ± 1.6 minutes). The sensory block duration was significantly longer in the PB group (187.9 ± 22.0 versus 106.5 ± 19.1 minutes). Additional injections were required in 16 (24.2%) DB cases, while no additional injections were required in PB cases. Four adverse events occurred in the DB group and two in the PB group. Conclusion: PB was a less painful anesthetic procedure associated with a longer sensory block duration and fewer repeat injections compared with DB. The result of this study implicates that PB can be an alternative anesthetic option in the surgical treatment of ingrown toenails.

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Skin penetration/permeation success determinants of nanocarriers: Pursuit of a perfect formulation

Colloids and Surfaces B Biointerfaces ◽

10.1016/j.colsurfb.2021.111748 ◽

2021 ◽

pp. 111748

Author(s):

Mohammed Elmowafy

Keyword(s):

Skin Penetration

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Microneedle Arrays Combined with Nanomedicine Approaches for Transdermal Delivery of Therapeutics

Journal of Clinical Medicine ◽

10.3390/jcm10020181 ◽

2021 ◽

Vol 10 (2) ◽

pp. 181

Author(s):

Vahid Alimardani ◽

Samira Sadat Abolmaali ◽

Gholamhossein Yousefi ◽

Zahra Rahiminezhad ◽

Mehdi Abedi ◽

...

Keyword(s):

Gene Therapy ◽

Transdermal Delivery ◽

Transdermal Drug Delivery ◽

Skin Barrier ◽

Skin Penetration ◽

Therapeutic Agents ◽

Inorganic Nanoparticles ◽

Microneedle Array ◽

Wide Range ◽

Microneedle Arrays

Organic and inorganic nanoparticles (NPs) have shown promising outcomes in transdermal drug delivery. NPs can not only enhance the skin penetration of small/biomacromolecule therapeutic agents but can also impart control over drug release or target impaired tissue. Thanks to their unique optical, photothermal, and superparamagnetic features, NPs have been also utilized for the treatment of skin disorders, imaging, and biosensing applications. Despite the widespread transdermal applications of NPs, their delivery across the stratum corneum, which is the main skin barrier, has remained challenging. Microneedle array (MN) technology has recently revealed promising outcomes in the delivery of various formulations, especially NPs to deliver both hydrophilic and hydrophobic therapeutic agents. The present work reviews the advancements in the application of MNs and NPs for an effective transdermal delivery of a wide range of therapeutics in cancer chemotherapy and immunotherapy, photothermal and photodynamic therapy, peptide/protein vaccination, and the gene therapy of various diseases. In addition, this paper provides an overall insight on MNs’ challenges and summarizes the recent achievements in clinical trials with future outlooks on the transdermal delivery of a wide range of nanomedicines.

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Cosmetics Europe evaluation of 6 in silico skin penetration models

Computational Toxicology ◽

10.1016/j.comtox.2021.100177 ◽

2021 ◽

pp. 100177

Author(s):

Sébastien Grégoire ◽

Ian Sorrell ◽

Daniela Lange ◽

Abdulkarim Najjar ◽

Andreas Schepky ◽

...

Keyword(s):

In Silico ◽

Skin Penetration

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The Topical Nanodelivery of Vismodegib Enhances Its Skin Penetration and Performance In Vitro While Reducing Its Toxicity In Vivo

Pharmaceutics ◽

10.3390/pharmaceutics13020186 ◽

2021 ◽

Vol 13 (2) ◽

pp. 186

Author(s):

Maria Natalia Calienni ◽

Daniela Maza Vega ◽

C. Facundo Temprana ◽

María Cecilia Izquierdo ◽

David E. Ybarra ◽

...

Keyword(s):

Side Effects ◽

Water Solubility ◽

Polymeric Micelles ◽

Skin Penetration ◽

Distribution Volume ◽

And Performance ◽

Oral Doses ◽

Advanced Basal Cell Carcinoma

Vismodegib is a first-in-class inhibitor for advanced basal cell carcinoma treatment. Its daily oral doses present a high distribution volume and several side effects. We evaluated its skin penetration loaded in diverse nanosystems as potential strategies to reduce side effects and drug quantities. Ultradeformable liposomes, ethosomes, colloidal liquid crystals, and dendrimers were able to transport Vismodegib to deep skin layers, while polymeric micelles failed at this. As lipidic systems were the most effective, we assessed the in vitro and in vivo toxicity of Vismodegib-loaded ultradeformable liposomes, apoptosis, and cellular uptake. Vismodegib emerges as a versatile drug that can be loaded in several delivery systems for topical application. These findings may be also useful for the consideration of topical delivery of other drugs with a low water solubility.

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