scholarly journals Functional physico-chemical, ex vivo permeation and cell viability characterization of omeprazole loaded buccal films for paediatric drug delivery

2016 ◽  
Vol 500 (1-2) ◽  
pp. 217-226 ◽  
Author(s):  
Sajjad Khan ◽  
Vivek Trivedi ◽  
Joshua Boateng
Keyword(s):  
Drug Delivery ◽  
Cell Viability ◽  
Ex Vivo ◽  
Paediatric Drug ◽  
Physico Chemical ◽  
Ex Vivo Permeation ◽  
Buccal Films

scholarly journals Comparison of the In Vitro and Ex Vivo Permeation of Existing Topical Formulations Used in the Treatment of Facial Angiofibroma and Characterization of the Variations Observed

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1060
Author(s):  
Guillaume Le Guyader ◽  
Bernard Do ◽  
Victoire Vieillard ◽  
Karine Andrieux ◽  
Muriel Paul
Keyword(s):  
Ex Vivo ◽  
Thermodynamic Activity ◽  
Physico Chemical ◽  
Ex Vivo Permeation ◽  
Franz Cells ◽  
Great Heterogeneity ◽  
The Impact ◽  
First Time

Rapamycin has been used topically to treat facial angiofibromas associated with tuberous sclerosis for more than a decade. In the absence of a commercial form, a large number of formulations have been clinically tested. However, given the great heterogeneity of these studies, particularly with regard to the response criteria, it was difficult to know the impact and thus to compare the relevance of the formulations used. The objective of this work was therefore to evaluate the link between the diffusion of rapamycin and the physico-chemical characteristics of these different formulations on Strat-M® membranes as well as on human skin using Franz cells. Our results underline the importance of the type of vehicle used (hydrogel > cream > lipophilic ointment), the soluble state of rapamycin and its concentration close to saturation to ensure maximum thermodynamic activity. Thus, this is the first time that a comparative study of the different rapamycin formulations identified in the literature for the management of facial angiofibromas has been carried out using a pharmaceutical and biopharmaceutical approach. It highlights the important parameters to be considered in the development and optimization of topical rapamycin formulations with regard to cutaneous absorption for clinical efficacy.

Nanostructured Lipid Carriers for Intranasal Administration of Olanzapine in the management of Schizophrenia

2021 ◽  
Vol 14 ◽  
Author(s):  
Sarbjot Kaur ◽  
Ujjwal Nautiyal ◽  
Pooja A. Chawla ◽  
Viney Chawla
Keyword(s):  
Drug Delivery ◽  
Ex Vivo ◽  
In Vitro Release ◽  
Nanostructured Lipid Carriers ◽  
Polydispersity Index ◽  
Poloxamer 407 ◽  
Ex Vivo Permeation ◽  
Permeation Studies ◽  
Vitro Release

Background: Background: Olanzapine belongs to a new class of dual spectrum antipsychotic agents. It is known to show promise in managing both the positive and negative symptoms of schizophrenia. Drug delivery systems based on nanostructured lipid carriers (NLC) are expected to provide rapid nose-to-brain transport of this drug and improved distribution into and within the brain. Objective: The present study deals with the preparation and evaluation of olanzapine loaded NLC via the intranasal route for schizophrenia. Methods: Olanzapine-NLC were formulated through the solvent injection method using isopropyl alcohol as the solvent, stearic acid as solid lipid, and oleic acid as liquid lipid, chitosan as a coating agent, and Poloxamer 407 as a surfactant. NLC were characterized for particle size, polydispersity index, entrapment efficiency, pH, viscosity, X-ray diffraction studies, in-vitro mucoadhesion study, in- vitro release and ex-vivo permeation studies. The shape and surface morphology of the prepared NLC was determined through transmission electron microscopy. To detect the interaction of the drug with carriers, compatibility studies were also carried out. Results: Average size and polydispersity index of developed formulation S6 was 227.0±6.3 nm and 0.460 respectively. The encapsulation efficiency of formulation S6 was found to be 87.25 %. The pH, viscosity, in-vitro mucoadhesion study, and in- vitro release of optimized olanzapine loaded NLC were recorded as 5.7 ± 0.05, 78 centipoise, 15±2 min, and 91.96 % respectively. In ex-vivo permeation studies, the percent drug permeated after 210 min was found to be 84.03%. Conclusion: These results reveal potential application of novel olanzapine-NLC in intranasal drug delivery system for treatment of schizophrenia.

scholarly journals Physico-Chemical, In Vitro and Ex Vivo Characterization of Meloxicam Potassium-Cyclodextrin Nanospheres

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1883
Author(s):  
Patrícia Varga ◽  
Rita Ambrus ◽  
Piroska Szabó-Révész ◽  
Dávid Kókai ◽  
Katalin Burián ◽  
...  
Keyword(s):  
Spray Drying ◽  
Ex Vivo ◽  
Average Particle Size ◽  
Rapid Onset ◽  
Average Particle ◽  
Nasal Drug Delivery ◽  
Onset Of Action ◽  
Physico Chemical

Nasal drug delivery has many beneficial properties, such as avoiding the first pass metabolism and rapid onset of action. However, the limited residence time on the mucosa and limited absorption of certain molecules make the use of various excipients necessary to achieve high bioavailability. The application of mucoadhesive polymers can increase the contact time with the nasal mucosa, and permeation enhancers can enhance the absorption of the drug. We aimed to produce nanoparticles containing meloxicam potassium (MEL-P) by spray drying intended for nasal application. Various cyclodextrins (hydroxypropyl-β-cyclodextrin, α-cyclodextrin) and biocompatible polymers (hyaluronic acid, poly(vinylalcohol)) were used as excipients to increase the permeation of the drug and to prepare mucoadhesive products. Physico-chemical, in vitro and ex vivo biopharmaceutical characterization of the formulations were performed. As a result of spray drying, mucoadhesive nanospheres (average particle size <1 µm) were prepared which contained amorphous MEL-P. Cyclodextrin-MEL-P complexes were formed and the applied excipients increased the in vitro and ex vivo permeability of MEL-P. The highest amount of MEL-P permeated from the α-cyclodextrin-based poly(vinylalcohol)-containing samples in vitro (209 μg/cm2) and ex vivo (1.47 μg/mm2) as well. After further optimization, the resulting formulations may be promising for eliciting a rapid analgesic effect through the nasal route.

Physico-chemical characterization of self-emulsifying drug delivery systems

2018 ◽  
Vol 27 ◽  
pp. 81-86 ◽  
Author(s):  
Zoltán Ujhelyi ◽  
Miklós Vecsernyés ◽  
Pálma Fehér ◽  
Dóra Kósa ◽  
Petra Arany ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Chemical Characterization ◽  
Delivery Systems ◽  
Physico Chemical

Physico-Chemical Characterization of Ramipril Using Clove Oil Based Microemulsion Drug Delivery System

2014 ◽  
Vol 1 (1) ◽  
pp. 43-50
Author(s):  
M. Joyce Nirmala ◽  
Murugesh Shivashankar ◽  
Vinita Ernest ◽  
Amitava Mukherjee ◽  
N. Chandrasekaran
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Chemical Characterization ◽  
Clove Oil ◽  
Physico Chemical

scholarly journals Formulation, Characterisation and Stabilisation of Buccal Films for Paediatric Drug Delivery of Omeprazole

2015 ◽  
Vol 16 (4) ◽  
pp. 800-810 ◽  
Author(s):  
Sajjad Khan ◽  
Joshua S. Boateng ◽  
John Mitchell ◽  
Vivek Trivedi
Keyword(s):  
Drug Delivery ◽  
Paediatric Drug ◽  
Buccal Films

scholarly journals EFFECT OF POLYMERIC BLEND ON EX-VIVO PERMEATION STUDIES OF ACECLOFENAC LOADED FILM FORMING GEL

2021 ◽  
pp. 117-122
Author(s):  
HIMANI BAJAJ ◽  
VINOD SINGH ◽  
RANJIT SINGH ◽  
TIRATH KUMAR
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Ex Vivo ◽  
Prepared Film ◽  
Variable Effect ◽  
Ex Vivo Permeation ◽  
Film Forming ◽  
Transdermal Drug Delivery Systems ◽  
Permeation Studies ◽  
Polymeric Blend

Objective: To date, film-forming systems have been intensively investigated for transdermal drug delivery. Film-forming systems offers various advantages compared over conventional transdermal drug delivery systems. The objective of the present study was to study the effect of polymeric blend on ex-vivo permeation studies of topical film-forming gel of aceclofenac. Methods: Film-forming gels were prepared by using Hydroxypropyl methylcellulose and Eudragit polymeric blend in varied concentrations, polyethylene glycol 400 as plasticizer, ethanol as solvent and tween 80 as a penetration enhancer. The prepared film-forming gels were evaluated and the influence of the concentration and ratio of polymeric blends used plasticizer and ethanol were investigated. Results: All the prepared film-forming gels showed satisfactory properties regarding homogeneity, compatibility, viscosity and pH value. Variation in the concentration of polymers showed a variable effect on drug permeation rate from film-forming gels. Almost, all formulations permeated up to 80% of drug in 12 h and formulation F1 showed a maximum release about 97.54 % in 12 h. Conclusion: Film-forming gels of aceclofenac with sustained-release profile were successfully developed and may provide a promising effective formulation which may improve patient compliance.

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